ChemicalBook > CAS DataBase List > U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST
U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST
- Product Name
- U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST
- CAS No.
- 87151-85-7
- Chemical Name
- U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST
- Synonyms
- Spiradoline;Espiradolina;Spiradolinum;U-62066 solid;Spiradolinum [latin];Espiradolina [spanish];Spiradoline mesylate salt;U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST;Benzeneacetamide, 3,4-dichloro-N-methyl-N-[(5S,7R,8R)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-, rel-;(±)-(5α,7α,8β)-3,4-dichloro-n-methyl-n-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]benzeneacetamide mesylate salt
- CBNumber
- CB2972242
- Molecular Formula
- C22H30Cl2N2O2
- Formula Weight
- 425.39
- MOL File
- 87151-85-7.mol
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U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST Property
- storage temp.
- 2-8°C
- solubility
- H2O: soluble14mg/mL
- form
- solid
- color
- white
- Water Solubility
- H2O: 14mg/mL
methanol: insoluble
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- U105
- Product name
- U-62066
- Purity
- solid
- Packaging
- 25mg
- Price
- $121
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- U105
- Product name
- U-62066
- Purity
- solid
- Packaging
- 100mg
- Price
- $354
- Updated
- 2025/07/31
TRC
- Product number
- U100230
- Product name
- U62066
- Packaging
- 5mg
- Price
- $130
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- BRS0000786
- Product name
- U-62066
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $626.15
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- BRS0000786
- Product name
- U-62066
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $789.51
- Updated
- 2021/12/16
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U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST Chemical Properties,Usage,Production
Uses
Analgesic.
Uses
U 62066 is a selective κ-opioid agonist. It exhibits analgesic, diuretic and antitussive properties.
Biological Activity
U-62066, also known as spiradoline, is a highly selective K opioid receptor agonist. It exhibits analgesic and diuretic effects. Antitussive property of U-62066 is observed in rats.
in vivo
Spiradoline (U-62066; 0.1-0.4 mg/kg; subcutaneous injection; once; Sprague-Dawley rats) treatment dose-dependently reduces social behaviors in non-stressed adults, producing social avoidance at the highest dose tested, while younger animals displays reduced sensitivity to this socially suppressing effect of Spiradoline. In stressed animals, the socially suppressing effects of the Spiradoline are blunted at all ages, with juveniles and adolescents exhibiting increased social preference in response to certain doses of U-62066[1].
| Animal Model: | Juvenile, adolescent and adult Sprague-Dawley male and female rats exposured to repeated restraint[1] |
| Dosage: | 0.1 mg/kg, 0.2 mg/kg, 0.3 mg/kg, and 0.4?mg/kg |
| Administration: | Subcutaneous injection; once |
| Result: | Dose-dependently reduced social behaviors in non-stressed adults, producing social avoidance at the highest dose tested. |
U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST Preparation Products And Raw materials
Raw materials
Preparation Products
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U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST Suppliers
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