ChemicalBook > CAS DataBase List > 5-Methylthiophene-2-boronic acid pinacol ester, 95%

5-Methylthiophene-2-boronic acid pinacol ester, 95%

Product Name
5-Methylthiophene-2-boronic acid pinacol ester, 95%
CAS No.
476004-80-5
Chemical Name
5-Methylthiophene-2-boronic acid pinacol ester, 95%
Synonyms
5-methylthiophene-2-borate;4,4,5,5-Tetramethyl-2-(5-methylthiophen-2-yl);5-Methylthiophen-2-boronic acid pinacol ester;5-Methylthiophene-2-boronic acid pinacol ester;5-Methylthiophene-2-boronicacidpinacolester,95%;5-Methylthiophene-2-boronic acid pinacol ester 95%;5-Methylthiophene-2-boronic acid pinacol ester, 95%;2-(5-Methyl-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;4,4,5,5-Tetramethyl-2-(5-methyl-2-thienyl)-1,3,2-dioxaborolane;1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-(5-methyl-2-thienyl)-
CBNumber
CB2972444
Molecular Formula
C11H17BO2S
Formula Weight
224.13
MOL File
476004-80-5.mol
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5-Methylthiophene-2-boronic acid pinacol ester, 95% Property

Boiling point:
308.2±30.0 °C(Predicted)
Density 
0.937
Flash point:
105 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Appearance
Light yellow to yellow Liquid
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Safety

Hazard Codes 
Xi
Risk Statements 
38
Safety Statements 
37
WGK Germany 
2
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
655074
Product name
5-Methylthiophene-2-boronic acid pinacol ester
Purity
95%
Packaging
1g
Price
$26.5
Updated
2023/06/20
Sigma-Aldrich
Product number
655074
Product name
5-Methylthiophene-2-boronic acid pinacol ester
Purity
95%
Packaging
10g
Price
$174
Updated
2023/06/20
TRC
Product number
T302835
Product name
4,4,5,5-Tetramethyl-2-(5-methylthiophen-2-yl)-1,3,2-dioxaborolane
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
AMTB677
Product name
5-Methyl-2-thiopheneboronicacidpinacolester
Packaging
5g
Price
$40
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
38028
Product name
4,4,5,5-Tetramethyl-2-(5-methylthiophen-2-yl)-1,3,2-dioxaborolane
Purity
95+%
Packaging
10g
Price
$400
Updated
2021/12/16
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5-Methylthiophene-2-boronic acid pinacol ester, 95% Chemical Properties,Usage,Production

Uses

5-Methylthiophene-2-boronic acid pinacol ester can be used as a reactant:

  • In the palladium-catalyzed Suzuki coupling reaction for the preparation of heteroaryl derivatives.
  • To synthesize N-(4-methylpyridin-2-yl)thiophene-2-carboxamide analog as potential inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
  • To prepare organic recyclable mechanoluminescent luminogen via Wittig and Suzuki reactions.

Synthesis

554-14-3

25015-63-8

476004-80-5

The general procedure for the synthesis of 5-methylthiophene-2-boronic acid pinacol ester from 2-methylthiophene and pinacolborane was carried out as follows: cobalt complex (0.01 mmol, selected from 1-4), 2-methylthiophene (1 mmol), and pinacolborane (1 mmol) were added to scintillation vials fitted with magnetic stirring bars according to the reaction scheme shown in Figure 2(a). The reaction progress was monitored by analyzing an aliquot of the mixture by GC-FID. The reaction mixture was stirred at room temperature until the reaction was complete and subsequently quenched by exposure to air. The resulting solid was dissolved in CDCl3, filtered through a Pasteur pipette fitted with a silicone plug and subsequently analyzed by 1H and 13C NMR spectroscopy without further purification. The above reaction can also be carried out in 2 ml of tetrahydrofuran (THF) if required. Figure 2(a) illustrates the percentage conversion of cobalt complexes 1-4, with the values in parentheses being the isolated yields. In addition, Figure 2(b) details other boronation products achieved using cobalt complexes 2 and 3 according to the previously described reaction conditions.

References

[1] Organic Letters, 2012, vol. 14, # 16, p. 4266 - 4269
[2] Patent: WO2015/89119, 2015, A1. Location in patent: Page/Page column 34
[3] Chemistry - An Asian Journal, 2010, vol. 5, # 7, p. 1657 - 1666
[4] Tetrahedron, 2008, vol. 64, # 26, p. 6103 - 6114
[5] Organometallics, 2015, vol. 34, # 19, p. 4732 - 4740

5-Methylthiophene-2-boronic acid pinacol ester, 95% Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Methylthiophene-2-boronic acid pinacol ester, 95% manufacturers

Career Henan Chemical Co
Product
5-Methylthiophene-2-boronic acid pinacol ester, 95% 476004-80-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg
Release date
2020-01-13

476004-80-5, 5-Methylthiophene-2-boronic acid pinacol ester, 95%Related Search:

5-(4 4 5 5-TETRAMETHYL-1 3 2-DIOXABOROL& Thiophene-2-boronic acid pinacol ester 5-Methylthiophene-2-boronic acid 2-PHENYLTHIOPHENE-5-BORONIC ACID PINACOL ESTER 5-(4-Morpholinylmethyl)thiophene-2-boronic acid pinacol ester 5-METHOXYCARBONYLTHIOPHENE-2-BORONIC ACID PINACOL ESTER 5-Methylthiophene-2-boronic acid pinacol ester, 95% 2,2'-Bithiophene-5,5'-diboronic acid bis(pinacol) ester 5-CARBOXYLTHIOPHENE-2-BORONIC ACID PINACOL ESTER 5-BROMO-5''-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2,2''-BITHIOPHENE 5'-HEXYL-2,2'-BITHIOPHENE-5-BORONIC ACID PINACOL ESTER 2,2':5',2"-Terthiophene-5-boronic acid pinacol ester, 97% 5-CYANOTHIOPHENE-2-BORONIC ACID PINACOL ESTER 2-(5-Hexyl-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-BROMO-5-METHYL-THIOPHENE-2-BORONIC ACID PINACOL ESTER 5-TRIFLUOROMETHYLTHIOPHENE-2-BORONIC ACID PINACOL ESTER 4-BROMO-3,5-DIMETHYL-THIOPHENE-2-BORONIC ACID PINACOL ESTER 2-ACETYLTHIOPHENE-5-BORONIC ACID PINACOL ESTER

  • 5-Methylthiophene-2-boronic acid pinacol ester, 95%
  • 4,4,5,5-TetraMethyl-2-(5-Methylthiophen-2-yl)-1,3,2-dioxaborolane
  • 5-Methylthiophene-2-boronic acid pinacol ester 95%
  • 3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-methylthiophen-2-yl)boronate
  • 5-Methylthiophen-2-boronic acid pinacol ester
  • 4,4,5,5-Tetramethyl-2-(5-methylthiophen-2-yl)
  • 2-(5-Methyl-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-(5-methyl-2-thienyl)-
  • 4,4,5,5-Tetramethyl-2-(5-methyl-2-thienyl)-1,3,2-dioxaborolane
  • 5-methylthiophene-2-borate
  • 5-Methylthiophene-2-boronicacidpinacolester,95%
  • 5-Methylthiophene-2-boronic acid pinacol ester
  • 476004-80-5
  • C11H19BO3S
  • C11H17BO2S