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PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM

Product Name
PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM
CAS No.
724709-68-6
Chemical Name
PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM
Synonyms
PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM;4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one;7H-Furo[3,2-g][1]benzopyran-7-one, 4-(4-phenylbutoxy)-
CBNumber
CB2973067
Molecular Formula
C21H18O4
Formula Weight
334.37
MOL File
724709-68-6.mol
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PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM Property

Melting point:
98 °C(Solv: methanol (67-56-1); water (7732-18-5))
Boiling point:
537.7±50.0 °C(Predicted)
Density 
1.246±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P9872
Product name
Psora-4
Purity
≥98% (HPLC)
Packaging
5mg
Price
$215
Updated
2022/05/15
Cayman Chemical
Product number
28389
Product name
Psora 4
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28389
Product name
Psora 4
Packaging
25mg
Price
$533
Updated
2024/03/01
Cayman Chemical
Product number
28389
Product name
Psora 4
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
28389
Product name
Psora 4
Packaging
10mg
Price
$230
Updated
2024/03/01
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PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM Chemical Properties,Usage,Production

Description

Psora 4 is an inhibitor of voltage-gated potassium channels (Kv1.3; EC50 = 3 nM). It is selective for Kv1.3 over Kv1.1, Kv1.2, Kv1.4, Kv1.7, and Kv3.1 channels (EC50s = 62, 49, 202, 100, and 1,500 nM, respectively) but does inhibit the Kv1.5 channel (EC50 = 7.7 nM). Psora 4 selectively binds to the C-type inactivated state of the Kv1.3 channel and inhibits potassium current in a use-dependent manner. It has immunosuppressive activity, inhibiting proliferation of human and rat myelin-specific effector memory T cells in vitro (TEM cells; EC50s = 25 and 60 nM, respectively).

Uses

Psora-4 is the most potent small-molecule Kv1.3 blocker known. Psora-4 and other Kv1.3 blockers may be useful as immunomodulators for the therapy of autoimmune disorders.

Definition

ChEBI: Psora 4 is a member of the class of psoralens that is psoralen substituted by a 4-phenylbutoxy group at position 5. It is a potent inhibitor of the voltage-gated potassium channel Kv1.3 (EC50 = 3 nM). It has a role as a geroprotector, a potassium channel blocker and an immunosuppressive agent. It is a member of benzenes, an aromatic ether and a member of psoralens.

Biochem/physiol Actions

The lymphocyte potassium channel Kv1.3 is regarded as a new target for immunosuppression. Psora-4 is the most potent small-molecule Kv1.3 blocker known. It blocked Kv1.3 in a use-dependent manner, with a Hill coefficient of 2 and an EC50 value of 3 nM, by preferentially binding to the C-type inactivated state of the channel. It exhibited 17- to 70-fold selectivity for Kv1.3 over closely related Kv1-family channels (Kv1.1, Kv1.2, Kv1.4, and Kv1.7) with the exception of Kv1.5 (EC50, 7.7 nM) and showed no effect on human ether-a-go-go-related channel, Kv3.1, the calcium-activated K+ channels (IKCa1, SK1-SK3, and BKCa), or the neuronal NaV1.2 channel. In a test of in vivo toxicity in rats, Psora-4 did not display any signs of acute toxicity after five daily subcutaneous injections at 33 mg/kg body weight. Psora-4 selectively suppressed the proliferation of human and rat myelin-specific effector memory T cells with EC50 values of 25 and 60 nM, respectively, without persistently suppressing peripheral blood naive and central memory T cells. Because autoantigen-specific effector memory T cells contribute to the pathogenesis of T cell-mediated autoimmune diseases such as multiple sclerosis, Psora-4 and other Kv1.3 blockers may be useful as immunomodulators for the therapy of autoimmune disord.

in vitro

psora-4 could block kv1.3 in a dose-dependent manner. psora-4 was found to be the most potent small-molecule kv1.3 blocker known. psora-4 exhibited 17- to 70-fold selectivity for kv1.3 over kv1-family channels including kv1.1, kv1.2, kv1.4, and kv1.7 and also showed no effect on human ether-a-go-go-related channel, kv3.1, or the neuronal nav1.2 channel. in addition, psora-4 could suppress the proliferation of rat and human myelin-specific effector memory t cells with ec50 values of 60 and 25 nm, respectively, without persistently suppressing the peripheral blood naive and central memory t cells [1].

in vivo

in a study of in vivo toxicity in rats, psora-4 was found not to show any signs of acute toxicity following five daily subcutaneous injections at 33 mg/kg body weight [1].

storage

Store at -20°C

References

[1] vennekamp j,wulff h,beeton c,calabresi pa,grissmer s,hnsel w,chandy kg. kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. mol pharmacol.2004 jun;65(6):1364-74.

PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM Suppliers

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724709-68-6, PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUMRelated Search:

Phenolphthalein diphosphate

  • PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM
  • 4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one
  • 7H-Furo[3,2-g][1]benzopyran-7-one, 4-(4-phenylbutoxy)-
  • 724709-68-6
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