BMS-P5
- Product Name
- BMS-P5
- CAS No.
- 1549811-36-0
- Chemical Name
- BMS-P5
- Synonyms
- BMS-P5 HCL;NET,BMS P5,myeloma,inhibit,Peptidylarginine Deiminase,Inhibitor,Protein Arginine Deiminase,Multiple,BMS-P5,BMS-P-5,BMSP5;((2S,5S)-5-amino-2-methylpiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride
- CBNumber
- CB29731093
- Molecular Formula
- C27H33ClN6O2
- Formula Weight
- 509.05
- MOL File
- 1549811-36-0.mol
BMS-P5 Property
- InChIKey
- UMXWDEKCDIDCBA-TVJVWYQLNA-N
- SMILES
- C(C1CC1)N1C2=NC=CC=C2C=C1C1=NC2=CC(C(N3C[C@H](N)CC[C@@H]3C)=O)=CC(OC)=C2N1C.Cl |&1:21,25,r|
BMS-P5 Chemical Properties,Usage,Production
Description
BMS-P5 is a Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor with pIC50 values in the range of 5-?7.5. BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Administration of BMS-P5 to multiple myeloma-bearing mice delays appearance of symptoms and disease progression Targeting PAD4 may be beneficial for treatment of multiple myeloma.
Biological Activity
BMS-P5 is an inhibitor of the protein arginine deiminase 4 (PAD4; IC50 = 0.098 μM). It is selective for PAD4 over PAD1, -2, and -3 (IC50s = >10 μM). BMS-P5 (1 μM) inhibits citrullination of histone H3 and neutrophil extracellular trap (NET) formation induced by RPMI-8226- or MM.1S-conditioned medium in isolated human neutrophils. It delays disease onset and increases survival in a DP42 syngeneic mouse model of multiple myeloma when administered at a dose of 50 mg/kg.
BMS-P5 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS-P5 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32080
- Advantage
- 58
View Lastest Price from BMS-P5 manufacturers
- Product
- BMS-P5 1549811-36-0
- Price
- US $0.00-0.00/MG
- Min. Order
- 1MG
- Purity
- 98
- Supply Ability
- 100G
- Release date
- 2024-04-17