GRAVEOLINE

Product Name: GRAVEOLINE
CAS No.: 485-61-0
Chemical Name: GRAVEOLINE
Synonyms: Rutamine;Graveoline, 10 mM in DMSO;2-(1,3-benzodioxol-5-yl)-1-methylquinolin-4-one;4(1H)-Quinolinone,2-(1,3-benzodioxol-5-yl)-1-methyl-;1-methyl-2-[3',4'-(methylenedioxy)phenyl]-4-quinolone;2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one
CBNumber: CB2981839
Molecular Formula: C17H13NO3
Formula Weight: 279.29
MOL File: 485-61-0.mol

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GRAVEOLINE Property

Melting point:: 204-205 °C
Boiling point:: 436.7±45.0 °C(Predicted)
Density: 1.327±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 1.74±0.70(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: G780015
Product name: Graveoline
Packaging: 60mg
Price: $985
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0016286
Product name: GRAVEOLINE
Purity: 95.00%
Packaging: 5MG
Price: $503.77
Updated: 2021/12/16

Chemenu

Product number: CM260861
Product name: 2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one
Purity: 97%
Packaging: 1g
Price: $608
Updated: 2021/12/16

Crysdot

Product number: CD11117581
Product name: 2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one
Purity: 97%
Packaging: 1g
Price: $644
Updated: 2021/12/16

Alichem

Product number: 485610
Product name: 2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one
Packaging: 1g
Price: $650
Updated: 2021/12/16

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GRAVEOLINE Chemical Properties,Usage,Production

Uses

Graveoline is an apoptosis and autophagy inducer in skin melanoma cancer cells.

Definition

ChEBI: Graveoline is a member of quinolines.

Synthesis

74054-38-9

74-88-4

485-61-0

Under nitrogen protection, 2-benzo[1,3]dioxol-5-yl-1H-quinolin-4-one (100 mg, 0.37 mmol) was dissolved in anhydrous N,N-dimethylformamide (5 mL) and stirred at room temperature. Potassium carbonate (156 mg, 1.1 mmol) and iodomethane (80 mg, 0.56 mmol) were added sequentially, and the reaction mixture was heated to 80 °C and stirred for 5 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched with ice water and extracted with dichloromethane (315 mL). The organic phase was dried with anhydrous sodium sulfate and the solvent was concentrated under reduced pressure to give the crude product. The crude product was purified by recrystallization from ethyl acetate to give an off-white solid (100 mg, 95% yield). Melting point: 188.6-191.4°C. IR (KBr, cm?1): 1621, 1599, 1490, 1446, 1251, 1032, 751. mass spectrum (ESI): m/z 280.3 [M+H]? 1H NMR (400 MHz, CDCl?) δ (ppm): 3.60 (s, 3H), 5.99 (s, 1H), 6.14 (s, 2H), 7.02 (d, 1H, J=7.2 Hz), 7.08 (d, 1H, J=8.0 Hz), 7.17 (s, 1H), 7.42-7.46 (m, 1H), 7.79 ( d, 2H, J=3.6 Hz), 8.22 (d, 1H, J=8.0 Hz).13C NMR (100 MHz, CDCl?) δ (ppm): 37.35, 101.72, 108.64, 109.00, 112.64, 116.04, 122.76, 123.68, 126.68, 126.81, 129.43, 132.81 129.43, 132.37, 141.97, 147.94, 148.77, 154.44, 177.59.The 1H and 13C NMR data of the obtained products are in agreement with literature reports.

References

[1] Synthetic Communications, 2018, vol. 48, # 20, p. 2635 - 2641
[2] Synthetic Communications, 1996, vol. 26, # 3, p. 495 - 501

GRAVEOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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GRAVEOLINE Suppliers

China 58 India 1 United States 6 Global 65

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Zhengzhou Gecko Scientific Inc.

Tel: 0371-63336364 17344886665
Fax: 0371-65511872
Email: 209932355@qq.com
Country: China
ProdList: 489
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Grice Rand (Tianjin) Pharmaceutical Co., Ltd.

Tel: 022-83705301 13752403750
Fax: 022-83705301
Email: 2966024760@qq.com
Country: China
ProdList: 873
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Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12476
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10110
Advantage: 58

Beijing Bewellunion Pharmaceutical Co., Ltd.

Tel: 18601958187
Fax: 18601958187
Email: 247340078@qq.com
Country: China
ProdList: 144
Advantage: 58

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View Lastest Price from GRAVEOLINE manufacturers

Honest Joy Holdings Limited

Product: 2-(1,3-benzodioxol-5-yl)-1-methylquinolin-4-one 485-61-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.2%
Supply Ability: 100 tons
Release date: 2022-01-17

485-61-0, GRAVEOLINERelated Search:

METANIL YELLOW METHYLENECYCLOHEXANE 2-PHENYL-1H-QUINOLIN-4-ONE 4-HYDROXY-2-METHYLQUINOLINE GRAVEOLINE

1-methyl-2-[3',4'-(methylenedioxy)phenyl]-4-quinolone

2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one

2-(1,3-benzodioxol-5-yl)-1-methylquinolin-4-one

4(1H)-Quinolinone,2-(1,3-benzodioxol-5-yl)-1-methyl-

Rutamine

Graveoline, 10 mM in DMSO

485-61-0