Upadacitinib hemihydrate

Product Name: Upadacitinib hemihydrate
CAS No.: 2050057-56-0
Chemical Name: Upadacitinib hemihydrate
Synonyms: Upadacitinib hemihydrate;ABT494 hemihydrate;ABT 494 hemihydrate;ABT-494 hemihydrate;Upadacitinib Hydrate;(3S,4R)-3-ethyl-4-(3H-imidazolo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide hydrate;Cinchonanium, 1-[13,5-bis(trifluoromethyllphenyllmethyl]-9-hydroxy-1'- [[3-(trifluoromethyl)phenyllmethyl},bromide(1:2), (8a,9R)-";1-Pyrrolidinecarboxamide, 3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-, hydrate (2:1), (3S,4R)-
CBNumber: CB29872273
Molecular Formula: C17H21F3N6O2
Formula Weight: 398.39
MOL File: 2050057-56-0.mol

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Upadacitinib hemihydrate Property

InChI: InChI=1/C17H19F3N6O.H2O/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15;/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27);1H2/t10-,11+;/s3
InChIKey: VJSRYIXHEWRBKD-NFGOAHBONA-N
SMILES: C([C@@H]1CN(C(=O)NCC(F)(F)F)C[C@@H]1C1=CN=C2C=NC3NC=CC=3N12)C.O |&1:1,13,r|

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Hazard and Precautionary Statements (GHS)

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Upadacitinib hemihydrate Chemical Properties,Usage,Production

Description

Upadacitinib is a selective and reversible Janus kinase (JAK) inhibitor recently approved by the European Medicine Agency and the Food and Drug Administration for the treatment of rheumatoid arthritis (RA).

Clinical Use

Upadacitinib(RINVOQ) is indicated for the treatment of moderate to severe active rheumatoid arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs (DMARDs). RINVOQ may be used as monotherapy or in combination with methotrexate. Each prolonged-release tablet (RINVOQ 15 mg prolonged-release tablets.) contains upadacitinib hemihydrate, equivalent to 15 mg of upadacitinib.

Side effects

The most common adverse effects with upadacitinib in the trials included urinary and upper respiratory tract infections, altered liver function and nausea. Rare but serious adverse events included malignancy, thrombosis and gastrointestinal perforation. As with other JAK inhibitors, serious and sometimes fatal infections can occur with upadacitinib – pneumonia and cellulitis were the most commonly reported in the trials. Opportunistic infections such as tuberculosis, multi-dermatomal herpes zoster, oral candidiasis, cryptococcosis and pneumocystosis have also occurred.

Upadacitinib hemihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Upadacitinib hemihydrate Suppliers

China 100 India 2 Global 102

Shan Dong FengJin Pharmaceutical Co.,Ltd.

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View Lastest Price from Upadacitinib hemihydrate manufacturers

Forest chemical technology

Product: Upadacitinib hemihydrate 2050057-56-0
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 1 ton/year
Release date: 2025-03-11

Cangzhou Kangrui Pharma Tech Co. Ltd.,

Product: Upadacitinib hemihydrate 2050057-56-0
Price: US $0.00-0.00/g
Min. Order: 50g
Purity: 99
Supply Ability: 10kgs
Release date: 2025-02-28

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Upadacitinib Hemihydrate 2050057-56-0
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-07-24

2050057-56-0, Upadacitinib hemihydrateRelated Search:

1-Pyrrolidinecarboxamide, 3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-, hydrate (2:1), (3S,4R)-

Upadacitinib hemihydrate

Upadacitinib Hydrate

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ABT 494 hemihydrate

ABT494 hemihydrate

ABT-494 hemihydrate

(3S,4R)-3-ethyl-4-(3H-imidazolo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide hydrate

2050057-56-0

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