ChemicalBook > CAS DataBase List > 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER

4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER

Product Name
4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER
CAS No.
28478-46-8
Chemical Name
4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER
Synonyms
Methyl 4-hydroxy-o-anisate;Methyl 4-hydroxy-2-methoxybenzoate;4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER;Benzoic acid, 4-hydroxy-2-methoxy-, methyl ester
CBNumber
CB31010650
Molecular Formula
C9H10O4
Formula Weight
182.18
MOL File
28478-46-8.mol
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4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER Property

Melting point:
150-151℃
storage temp. 
Inert atmosphere,Room Temperature
Appearance
White to off-white Solid
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Safety

HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M327263
Product name
Methyl4-​Hydroxy-​2-​methoxybenzoate
Packaging
250mg
Price
$185
Updated
2021/12/16
AK Scientific
Product number
2797AB
Product name
Methyl4-hydroxy-2-methoxybenzoate
Packaging
250mg
Price
$173
Updated
2021/12/16
Ambeed
Product number
A251096
Product name
Methyl4-Hydroxy-2-methoxybenzoate
Purity
97%
Packaging
100mg
Price
$64
Updated
2021/12/16
Ambeed
Product number
A251096
Product name
Methyl4-Hydroxy-2-methoxybenzoate
Purity
97%
Packaging
250mg
Price
$95
Updated
2021/12/16
Ambeed
Product number
A251096
Product name
Methyl4-Hydroxy-2-methoxybenzoate
Purity
97%
Packaging
1g
Price
$235
Updated
2021/12/16
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4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Methyl 4-?Hydroxy-?2-?methoxybenzoate is a reagent used in the synthesis of sphingosine-1-phosphate receptor agonist Ceralifimod used in the treatment of autoimmune diseases.

Synthesis

28478-45-7

28478-46-8

Step 3: A solution of EtOAc (200 mL) of methyl 2-methoxy-4-benzyloxybenzoate (40 g, 147 mmol) obtained in Step 2 was added to a Parr shaking flask, followed by 2 g of 10% Pd/C catalyst. The reaction mixture was placed in a Parr hydrogenation unit and shaken at 55 psi H2 pressure for 24 hours. Upon completion of the reaction, the catalyst was removed by filtration under argon protection and the solvent was removed by distillation under reduced pressure. The resulting solid was washed with a small amount of EtOAc, filtered and dried under vacuum for 24 h to give methyl 2-methoxy-4-hydroxybenzoate in 99% yield.

References

[1] Patent: US5665719, 1997, A
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 12, p. 2146 - 2163
[3] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 21, p. 3081 - 3086
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 3, p. 1059 - 1062
[5] Journal of Medicinal Chemistry, 1985, vol. 28, # 6, p. 717 - 727

4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER Suppliers

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View Lastest Price from 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER manufacturers

Career Henan Chemical Co
Product
4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER 28478-46-8
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2020-01-12

28478-46-8, 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTERRelated Search:

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  • Methyl 4-hydroxy-2-methoxybenzoate
  • Methyl 4-hydroxy-o-anisate
  • Benzoic acid, 4-hydroxy-2-methoxy-, methyl ester
  • 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER
  • 28478-46-8