Duocarmycin A

Product Name: Duocarmycin A
CAS No.: 118292-34-5
Chemical Name: Duocarmycin A
Synonyms: DC-88-A;Duocarmycin A;methyl (1R,4R,12S)-4-methyl-3,7-dioxo-10-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-5,10-diazatetracyclo[7.4.0.01,12.02,?]trideca-2(6),8-diene-4-carboxylate;(7bR,8aS)-2-[(5,6,7-Trimethoxy-1H-indole-2-yl)carbonyl]-1,2,4,5,8,8aβ-hexahydro-4,7-dioxo-6-methylcyclopropa[c]pyrrolo[3,2-e]indole-6β-carboxylic acid methyl ester;(6R,7bR,8aS)-1,2,4,5,6,7,8,8aβ-Octahydro-6-methyl-4,7-dioxo-2-(5,6,7-trimethoxy-1H-indol-2-ylcarbonyl)cyclopropa[c]pyrrolo[3,2-e]indole-6β-carboxylic acid methyl ester;Cyclopropacpyrrolo3,2-eindole-6-carboxylic acid, 1,2,4,5,6,7,8,8a-octahydro-6-methyl-4,7-dioxo-2-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (6R,7bR,8aS)-
CBNumber: CB31016713
Molecular Formula: C26H25N3O8
Formula Weight: 507.496
MOL File: 118292-34-5.mol

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Duocarmycin A Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0011291
Product name: DUOCARMYCIN A
Purity: 95.00%
Packaging: 5MG
Price: $501.73
Updated: 2021/12/16

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Duocarmycin A Chemical Properties,Usage,Production

Uses

Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].

IC 50

Procaspase-3; Caspase-9; Duocarmycins

References

[1] Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96. DOI:10.1016/j.biocel.2007.01.019

Duocarmycin A Preparation Products And Raw materials

Raw materials

Preparation Products

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Duocarmycin A Suppliers

China 13 United States 3 Global 16

Beijing Jin Ming Biotechnology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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HUNAN CHEMFISH SCIENTIFIC CO.,LTD

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BOC Sciences

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Jinan ponder chemical co. LTD

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Zhejiang Huida Biotech Co., LTD

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cjbscvictory

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Beijing Jin Ming Biotechnology Co., Ltd.

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Zhejiang Huida Biotech Co., LTD

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118292-34-5, Duocarmycin A Related Search:

3-azabicyclo[3.1.0]hexane 7-Methoxy-1H-indole 5,6-Dimethoxyindole Methyl 2-amino-3-oxobutanoate (R)-2-Amino-2-methyl-4-pentenoic acid 5-Methyl-D-norleucine DL-2-AMINO-4-PENTENOIC ACID 7-Hydroxyindole DL-ALLYLGLYCINE 1-CYCLOPROPYL-PROPAN-2-ONE D-METHALLYLGLYCINE R-2-Aminoctanoic acid (D,L)-2-AMINO-HEPT-6-ENOIC ACID 1-(1-METHYLCYCLOPROPYL)ACETONE H-D-LYS(AC)-OH 5-methoxyindolyl-2-methylamine Duocarmycin A 5-hydroxy-6-methoxyindole

Duocarmycin A

Cyclopropacpyrrolo3,2-eindole-6-carboxylic acid, 1,2,4,5,6,7,8,8a-octahydro-6-methyl-4,7-dioxo-2-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (6R,7bR,8aS)-

(6R,7bR,8aS)-1,2,4,5,6,7,8,8aβ-Octahydro-6-methyl-4,7-dioxo-2-(5,6,7-trimethoxy-1H-indol-2-ylcarbonyl)cyclopropa[c]pyrrolo[3,2-e]indole-6β-carboxylic acid methyl ester

(7bR,8aS)-2-[(5,6,7-Trimethoxy-1H-indole-2-yl)carbonyl]-1,2,4,5,8,8aβ-hexahydro-4,7-dioxo-6-methylcyclopropa[c]pyrrolo[3,2-e]indole-6β-carboxylic acid methyl ester

DC-88-A

methyl (1R,4R,12S)-4-methyl-3,7-dioxo-10-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-5,10-diazatetracyclo[7.4.0.01,12.02,?]trideca-2(6),8-diene-4-carboxylate

118292-34-5

C26H25N3O8