Lignoceric acid-d9

Lignoceric acid-d9 Property

Boiling point:

405.866±8.00 °C(Press: 760.00 Torr)(predicted)

Density 

0.879±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

form 

Solid

color 

White to off-white

Hazard and Precautionary Statements (GHS)

Lignoceric acid-d9 Chemical Properties,Usage,Production

Uses

Lignoceric acid-d9 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Anna Petroni, et al. Thermogenic flux induced by lignoceric acid in peroxisomes isolated from HepG2 cells and from X-adrenoleukodystrophy and control fibroblasts. J Cell Physiol. 2019 Aug;234(10):18344-18348. DOI:10.1002/jcp.28467
[3] J M Bourre, et al. Lignoceric acid biosynthesis in the developing brain. Activities of mitochondrial acetyl-CoA-dependent synthesis and microsomal malonyl-CoA chain-elongating system in relation to myelination. Comparison between normal mouse and dysmyelinating mutants (quaking and jimpy). Eur J Biochem. 1977 Jan 3;72(1):41-7. DOI:10.1111/j.1432-1033.1977.tb11222.x