TRIMIPRAMINE MALEATE SALT

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TRIMIPRAMINE MALEATE SALT

Product Name: TRIMIPRAMINE MALEATE SALT
CAS No.: 521-78-8
Chemical Name: TRIMIPRAMINE MALEATE SALT
Synonyms: TRIMIPRAMINE MALEATE;Trimipramina;surmontilmaleate;Einecs 208-318-3;trimepriminemaleate;TRIMIPRAMINEMALEATE,BP;Trimeprimine Monomaleat;trimipramineacidmaleate;trimepriminemonomaleate;Trimipramine maleate CRS
CBNumber: CB3104538
Molecular Formula: C24H30N2O4
Formula Weight: 410.51
MOL File: 521-78-8.mol

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TRIMIPRAMINE MALEATE SALT Property

Melting point:: 141-143°C
Flash point:: 11 °C
storage temp.: 2-8°C
solubility: chloroform: soluble50 mg/ml, clear, colorless to faintly yellow
form: powder
color: white
EPA Substance Registry System: Trimipramine maleate (521-78-8)

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 22-36/37/38-63-36/38-23/25-39/23/24/25-23/24/25-11
Safety Statements: 26-36-45-33-24-16-7-36/37
RIDADR: 3249
WGK Germany: 3
RTECS: HN9260000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2933996100

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T3146
Product name: Trimipramine maleate salt
Purity: ≥98% (TLC), powder
Packaging: 5g
Price: $96.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR3151
Product name: Trimipramine Maleate
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 200MG
Price: $200
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1692709
Product name: Trimipramine maleate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100mg
Price: $288
Updated: 2024/03/01

Cayman Chemical

Product number: 15921
Product name: Trimipramine (maleate)
Purity: ≥95%
Packaging: 1g
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 15921
Product name: Trimipramine (maleate)
Purity: ≥95%
Packaging: 5g
Price: $85
Updated: 2024/03/01

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TRIMIPRAMINE MALEATE SALT Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Originator

Surmontil Wyeth-Ayerst,Laboratories

Uses

Antidepressant; serotonin transport blocker that also blocks norepinephrine uptake.

Uses

Antidepressant;Noradrenaline uptake inhibitor

Manufacturing Process

Bis(3-dimethylamino-2-methylpropyl)-5-iminodibenzylyl carboxylic acid at 185-250°C up to discontinue a separation of oxyde carbonique. The product was dissolved in ether, then washed with the hydrochloric acid. Then this solution was extracted with ether. The solvent was evaporated under vacuum, to give pure oil bis(3-dimethylamino-2-methyl-1-propyl)-5-iminodibenzyle with boiling point 153-154°C at 0.4 mm. Maleate of bis(3-dimethylamino-2-methyl- 1-propyl)-5-iminodibenzyle have melting point 145-146°C.

brand name

Surmontil (Odyssey).

Therapeutic Function

Antidepressant

General Description

For details of chemical nomenclature, consult the descriptionof imipramine. Replacement of hydrogen with an -methylsubstituent produces a chiral carbon, and trimipramine(Surmontil) is used as the racemic mixture. Biological propertiesreportedly resemble those of imipramine.

Biological Activity

trimipramine (maleate) is a potent antagonist of histamine h1 receptor, serotonin 5-ht2a, and α1-adrenergic receptors [1].the histamine h1 receptor is widely expressed tissues, such as smooth muscles, vascular endothelial cells, heart, and the central nervous system. histamine h1 receptor (h1r) antagonists are very effective drugs alleviating the symptoms of allergic reactions [2]. 5-ht2a receptor shows constitutive activity. variations in5-ht2a receptor can produce profound alterations in cognitive states [3]. the adrenergic receptors play an important role in modulating sympathetic nervous system activity as well as a site of action for many therapeutic agents. the α1-adrenergic receptor is the prime mediators of smooth muscle contraction and hypertrophic growth. the α1-adrenergic receptor plays an essential role in smooth muscle, growth, neurological, and cardiovascular function [4].trimipramine (maleate) is a tricyclic antidepressant compound that antagonizes several types of neurotransmitter receptors. trimipramine potently antagonized the activity of histamine h1 serotonin 5-ht2a, and α1-adrenergic receptors with the kd value of 0.27 nm, 24 nm, and 24 nm, respectively. trimipramine moderately antagonized the activity of dopamine d2 with the kd of 180 nm. trimipramine inhibited the activity of muscarinic acetylcholine with the kd of 58 nm. trimipramine weakly inhibited the activity of 5-ht2c, d1, α2-adrenergic receptors (kd = 680 nm) [1]. trimipramine (maleate) was a weak to moderate reuptake inhibitor of serotonin (ki = 149 nm for sert), and an extremely weak inhibitor of norepinephrine (ki = 2.5 μm for net) and dopamine (ki = 3.8 μm for dat) reuptake in slices of rat cerebral cortex [5,6].

Biochem/physiol Actions

Antidepressant; serotonin transport blocker that also blocks norepinephrine uptake.

References

[1] richelson e, nelson a. antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro[j]. journal of pharmacology and experimental therapeutics, 1984, 230(1): 94-102.
[2] shimamura t, shiroishi m, weyand s, et al. structure of the human histamine h1 receptor complex with doxepin[j]. nature, 2011, 475(7354): 65-70.
[3] harvey j a. role of the serotonin 5-ht2a receptor in learning[j]. learning & memory, 2003, 10(5): 355-362.
[4] piascik m t, perez d m. α1-adrenergic receptors: new insights and directions[j]. journal of pharmacology and experimental therapeutics, 2001, 298(2): 403-410.
[5] gross g, xie x, gastpar m. trimipramine: pharmacological reevaluation and comparison with clozapine[j]. neuropharmacology, 1991, 30(11): 1159-1166.
[6] tatsumi m, groshan k, blakely r d, et al. pharmacological profile of antidepressants and related compounds at human monoamine transporters[j]. european journal of pharmacology, 1997, 340(2): 249-258.

TRIMIPRAMINE MALEATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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521-78-8, TRIMIPRAMINE MALEATE SALTRelated Search:

Trimipramine-D3 maleate Chlorphenamine maleate Trimebutine maleate Enalapril maleate TRIMIPRAMINE DESIPRAMINE Triprolidine oxalate salt TRIMIPRAMINE MALEATE SALT IMIPRAMINE Iminodibenzyl Trimipramine-d3 Maleate Salt

TRIMIPRAMINE MALEATE

TRIMIPRAMINE MALEATE SALT

f)azepine,10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-5h-dibenz(mal

surmontilmaleate

trimepriminemaleate

trimepriminemonomaleate

trimipramineacidmaleate

trimipramine hydrogen maleate

TRIMIPRAMINE MALEATE METHANOL SOLUTION

10,11-Dihydro-N,N,b-trimethyl-5H-dibenz[b,f]azepine-5-propanamine (2Z)-2-butenedioate

Trimeprimine Monomaleat

Trimipramina

5H-Dibenzb,fazepine-5-propanamine, 10,11-dihydro-N,N,.beta.-trimethyl-, (2Z)-2-butenedioate (1:1)

TRIMIPRAMINEMALEATE,BP

5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-, maleate (1:1) (8CI)

10,11-Dihydro-N,N,-trimethyl-5H-dibenz[b,f]azepine-5-propanamine (2Z)-2-butenedioate

Trimipramine solution maleate salt

5H-Dibenz(B,F)azepine, 10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-, maleate (1:1)

5H-Dibenz(B,F)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (Z)-2-butenedioate (1:1)

Einecs 208-318-3

Trimipramine Maleate (100 mg)

Trimipramine maleate salt solution

Trimipramine maleate CRS

Trimipramine for peak identification CRS

(2RS)-3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2- trimethylpropan-1-amine (Z)-butenedioate

Trimipramine maleateQ: What is Trimipramine maleate Q: What is the CAS Number of Trimipramine maleate Q: What is the storage condition of Trimipramine maleate Q: What are the applications of Trimipramine maleate

Trimipramine Maleate (1692709)

3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine maleate

hOCT3,hNAT,dopamine,5-HTIA receptors,neurological disease,serotonin,5-HT1A,5-hydroxytryptamine,5-HT,Inhibitor,antidepressants,5-hydroxytryptamine Receptor,Serotonin Receptor,Bacterial,hOCT1,5-HT1C,hDAT,Trimipramine,Trimipramine maleate,inhibit,5-HT2,hSERT,noradrenaline,human organic cation transporters,anxiolytic,DA D2 receptor,5-HTlc receptors,5-HT Receptor,hOCT2

Trimipramine maleate in methanol

521-78-8

C20H26N2C4H4O4

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