Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI)
- Product Name
- Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI)
- CAS No.
- 134000-96-7
- Chemical Name
- Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI)
- Synonyms
- 2-Chloro-5-fluoro-4-methylpyrimidine;PyriMidine, 2-chloro-5-fluoro-4-Methyl-;Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI);Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI) ISO 9001：2015 REACH
- CBNumber
- CB31046499
- Molecular Formula
- C5H4ClFN2
- Formula Weight
- 146.55
- MOL File
- 134000-96-7.mol
Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI) Property
- Boiling point:
- 220℃
- Density
- 1.352
- Flash point:
- 87℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.05±0.29(Predicted)
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PC201121
- Product name
- 2-Chloro-5-fluoro-4-methylpyrimidine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 3H31-7-2V
- Product name
- 2-Chloro-5-fluoro-4-methylpyrimidine
- Purity
- 98%
- Packaging
- 100mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- X9866
- Product name
- 2-Chloro-5-fluoro-4-methylpyrimidine
- Packaging
- 100mg
- Price
- $167
- Updated
- 2021/12/16
- Product number
- 3H31-7-2V
- Product name
- 2-Chloro-5-fluoro-4-methylpyrimidine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $208
- Updated
- 2021/12/16
- Product number
- PC201121
- Product name
- 2-Chloro-5-fluoro-4-methylpyrimidine
- Purity
- 98%
- Packaging
- 100mg
- Price
- $82
- Updated
- 2021/12/16
Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI) Chemical Properties,Usage,Production
Synthesis
75-16-1
2927-71-1
134000-96-7
Intermediate 55: Synthesis of 2-chloro-5-fluoro-4-methylpyrimidine. 2,4-Dichloro-5-fluoropyrimidine (1.02 g, 6.08 mmol) and Fe(acac)3 (215 mg, 0.61 mmol) were dissolved in a THF/NMP solvent mixture (38 mL/3 mL) and the mixture was cooled to 0 °C. A 3.0 M solution of Et2O of methylmagnesium bromide (3.04 mL, 9.12 mmol) was added slowly and dropwise. The reaction was completed after 30 min at 0 °C and quenched with saturated aqueous NH4Cl solution. Et2O was added for stratification and the aqueous layer was extracted several times with Et2O. The organic layers were combined, dried with Na2SO4, filtered and concentrated in vacuum. Purification by column chromatography (eluent: hexane to 10% EtOAc/hexane) afforded the target product 2-chloro-5-fluoro-4-methylpyrimidine as a waxy white solid (430 mg, 48% yield).1H NMR (400 MHz, CDCl3): δ 8.35 (s, 1H), 2.55 (d, J=2.5 Hz, 3H).
References
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 8, p. 3263 - 3282
[2] Patent: WO2011/50200, 2011, A1. Location in patent: Page/Page column 84
[3] Patent: WO2011/50198, 2011, A1. Location in patent: Page/Page column 74
[4] Patent: WO2012/145581, 2012, A1. Location in patent: Page/Page column 74
[5] Patent: WO2015/89143, 2015, A1. Location in patent: Page/Page column 95
Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI) manufacturers
- Product
- 2-Chloro-5-fluoro-4-methylpyrimidine 134000-96-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.8%
- Supply Ability
- 100 tons
- Release date
- 2022-01-25
- Product
- Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI) 134000-96-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-08