ChemicalBook > CAS DataBase List > Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)

Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)

Product Name
Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
CAS No.
262295-94-3
Chemical Name
Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
Synonyms
4-(Boc-amino)picolinonitrile;tert-butyl 2-cyanopyridin-4-ylcarbamate;tert-butyl N-(2-cyano-4-pyridyl)carbamate;(2-Cyano-pyridin-4-yl)-carbamic acid tert-butyl ester;N-(2-cyano-4-pyridinyl)carbamic acid tert-butyl ester;Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester;Carbamic acid, N-(2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester;Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
CBNumber
CB31053264
Molecular Formula
C11H13N3O2
Formula Weight
219.24
MOL File
262295-94-3.mol
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Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Synthonix
Product number
C38313
Product name
tert-Butyl (2-cyanopyridin-4-yl)carbamate
Purity
95+%
Packaging
100mg
Price
$100
Updated
2026/05/06
Synthonix
Product number
C38313
Product name
tert-Butyl (2-cyanopyridin-4-yl)carbamate
Purity
95+%
Packaging
250mg
Price
$110
Updated
2026/05/06
Synthonix
Product number
C38313
Product name
tert-Butyl (2-cyanopyridin-4-yl)carbamate
Purity
95+%
Packaging
1g
Price
$440
Updated
2026/05/06
Synthonix
Product number
C38313
Product name
tert-Butyl (2-cyanopyridin-4-yl)carbamate
Purity
95+%
Packaging
5g
Price
$2200
Updated
2026/05/06
aablocks
Product number
AA002SAJ
Product name
Tert-Butyl (2-Cyanopyridin-4-Yl)Carbamate
Purity
95%
Packaging
250mg
Price
$74
Updated
2026/05/28
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Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Usage,Production

Synthesis

4248-19-5

62150-45-2

262295-94-3

GENERAL STEPS: To a solution of 4-bromopyridine-2-carbonitrile (20 g, 109.29 mmol) in 1,4-dioxane (300 mL) was added sequentially Pd(OAc)2 (2.98 g, 13.27 mmol), XPhos (18.9 g, 39.34 mmol) and Cs2CO3 (50.3 g, 154.38 mmol). The reaction mixture was stirred at 100 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and solid impurities were removed by filtration. The filtrate was concentrated under reduced pressure and purified by fast column chromatography (eluent: EtOAc/petroleum ether = 1/3, v/v) to afford the target compound tert-butyl (2-cyanopyridin-4-yl)carbamate as a yellow solid (23 g, 95% yield).LC-MS (ES, m/z): 220 [M + H]+. 1H NMR (300 MHz, CDCl3) : δ 8.49 (d, J = 5.6 Hz, 1H), 7.87 (d, J = 2.2 Hz, 1H), 7.43 (dd, J = 5.6, 2.2 Hz, 1H), 6.90 (s, 1H), 1.54 (s, 9H) ppm.

References

[1] Patent: US2016/243100, 2016, A1. Location in patent: Paragraph 0257-0258

Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Suppliers

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262295-94-3, Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)Related Search:


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