Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI)

Product Name: Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI)
CAS No.: 101714-41-4
Chemical Name: Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI)
Synonyms: BIX;BiP inducer X;BIX >=98% (HPLC);BiP protein Inducer X;Thiocyanic acid 3,4-dihydroxyphenacyl ester;2-(Cyanosulfanyl)-1-(3,4-dihydroxyphenyl)ethan-1-one;2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid;Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester;Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI);GRP78,Apoptosis,BiP,Inhibitor,inhibit,GRP94,BiP inducer X,stress,neurons,calreticulin
CBNumber: CB31060509
Molecular Formula: C9H7NO3S
Formula Weight: 209.22
MOL File: 101714-41-4.mol

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Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI) Property

Melting point:: 127 °C
Boiling point:: 517℃
Density: 1.476
Flash point:: 267℃
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 7.54±0.20(Predicted)
color: white to beige
InChI: InChI=1S/C9H7NO3S/c10-5-14-4-9(13)6-1-2-7(11)8(12)3-6/h1-3,11-12H,4H2
InChIKey: SVFLBLCWKKQKDW-UHFFFAOYSA-N
SMILES: S(CC(C1=CC=C(O)C(O)=C1)=O)C#N

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1073
Product name: BIX
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1073
Product name: BIX
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $476
Updated: 2024/03/01

Tocris

Product number: 5375
Product name: BIX
Purity: ≥98%(HPLC)
Packaging: 50
Price: $357
Updated: 2021/12/16

Tocris

Product number: 5375
Product name: BIX
Purity: ≥98%(HPLC)
Packaging: 10
Price: $85
Updated: 2021/12/16

TRC

Product number: B591768
Product name: BIX
Packaging: 5mg
Price: $65
Updated: 2021/12/16

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Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI) Chemical Properties,Usage,Production

Uses

BIX has been used in cell viability assay.

Definition

ChEBI: 2-(3,4-dihydroxyphenyl)-2-oxoethyl thiocyanate is a member of the class of thiocyanates that is 3,4-dihydroxyacetophenone in which one of the methyl hydrogens has been replaced by the sulfur of a cyanosulfanediyl (-SC#N) group. It has been found to induce the expression of the endoplasmic reticulum chaperone protein GRP78 (78 kDa glucose-regulated protein, BiP, a highly conserved member of the 70 kDa heat shock protein family) leading to an attenuation of the unfolded protein response. It protects neuronal cells and retinal cells from endoplasmic reticulum (ER)-stress induced cell death. It is a member of thiocyanates, an aromatic ketone and a member of catechols.

Biochem/physiol Actions

BIX (BiP protein inducer X) induces the expression of the endoplasmic reticulum chaperone protein GRP78 (glucose regulated protein 78, BiP) leading to an attenuation of the unfolded protein response. BIX protects neuronal cells and retinal cells from ER-stress induced cell death.

Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI) Suppliers

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101714-41-4, Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI)Related Search:

Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI)

Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester

BiP inducer X

2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid

BiP protein Inducer X

BIX

Thiocyanic acid 3,4-dihydroxyphenacyl ester

BIX >=98% (HPLC)

2-(Cyanosulfanyl)-1-(3,4-dihydroxyphenyl)ethan-1-one

GRP78,Apoptosis,BiP,Inhibitor,inhibit,GRP94,BiP inducer X,stress,neurons,calreticulin

101714-41-4

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