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ISOTHIPENDYL

Product Name
ISOTHIPENDYL
CAS No.
482-15-5
Chemical Name
ISOTHIPENDYL
Synonyms
Adanton;Odantol;Udantol;Vdantor;Andantol;Andanton;AY 56012;Nilergex;Theruhistin;ISOTHIPENDYL
CBNumber
CB3106204
Molecular Formula
C16H19N3S
Formula Weight
285.41
MOL File
482-15-5.mol
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ISOTHIPENDYL Property

Boiling point:
bp0.4mm 171-174°
Density 
1.1618 (rough estimate)
refractive index 
1.5605 (estimate)
pka
8.82±0.50(Predicted)
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Safety

Toxicity
LD50 in mice (mg/kg): 65 ±2 i.p.; 222 ±18 orally (Schlichtegroll)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0011733
Product name
ISOTHIPENDYL
Purity
95.00%
Packaging
50MG
Price
$315
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0011733
Product name
ISOTHIPENDYL
Purity
95.00%
Packaging
500MG
Price
$1871.1
Updated
2021/12/16
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ISOTHIPENDYL Chemical Properties,Usage,Production

Originator

Theruhistin,Ayerst,US,1957

Uses

Antihistaminic.

Definition

ChEBI: Isothipendyl is a tertiary amino compound and an aromatic amine.

Manufacturing Process

85 parts of phenylpyridyl amine, 21 parts of powdered sulfur and 1.7 parts of iodine were heated to 275°C for two hours. Evolution of hydrogen sulfide began when the mixture reached a temperature of 250°C and became vigorous when it reached 275°C. Such evolution of hydrogen sulfide diminished after about one hour at 275°C. A light oil was distilled from the reaction mixture under vacuum (pressure = 2-3 mm Hg). This oil which contained phenylpyridyl amine in addition to the thiophenylpyridyl amine was then treated at boiling temperature with approximately the theoretical amount of 2-3 normal HCl until complete solution resulted with formation of the HCl salts of the amines. The solution was then treated with 1 to 2% (based upon the substance mixture) of active carbon and then filtered hot. The nitrate was then cooled to 0°C whereupon the thiophenylpyridyl amine hydrochloride crystallized out while the phenylpyridyl amine hydrochloride remained in solution. The thiophenylpyridyl amine hydrochloride was filtered off and suspended in water and the pH adjusted with half concentrated ammonia to 8. The thiophenylpyridyl amine set free was filtered off and dried. It was in the form of gold yellow needles and had a melting point of 114°C to 115°C.
40 parts of thiophenylpyridyl amine were dissolved in 200 parts of water free toluene. After the addition of 16 parts of soda amide, the mixture was refluxed for 1% hours. Thereafter, 28 parts of dimethylaminoisopropyl chloride in 30 parts of water free toluene were dropped in and the temperature maintained at 20°C to 25°C for 30 minutes. Thereafter, the mixture was heated at 60°C for 30 minutes and subsequently refluxed for 20 minutes. Water and hydrochloride acid were then added to the reaction mixture and this mixture rendered alkaline with NaOH and then the alkalized mixture shaken out with ether. The dimethylaminoisopropyl-N9-thiophenylpyridyl amine base thus obtained was vacuum distilled. It was then converted to hydrochloride salt. The monohydrochloride salt is almost white in color and melts at 213°C to 216°C. The yield was almost 100% of the theoretical.

Therapeutic Function

Antihistaminic

Safety Profile

A poison by ingestion andintraperitoneal routes. When heated to decomposition itemits toxic vapors of NOx and SOx.

ISOTHIPENDYL Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOTHIPENDYL Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
22784
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
17691182729 18161915376
Email
1046@dideu.com
Country
China
ProdList
10001
Advantage
58
zhenJiang HuiRui chem-tech Co;Ltd
Tel
15951285981
Email
huiruisales@163.com
Country
China
ProdList
511
Advantage
58
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View Lastest Price from ISOTHIPENDYL manufacturers

Dideu Industries Group Limited
Product
Isothipendyl
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-17

482-15-5, ISOTHIPENDYLRelated Search:


  • N,N,α-TriMethyl-10H-pyrido[3,2-b][1,4]benzothiazine-10-ethanaMine
  • 10H-Pyrido[3,2-b][1,4]benzothiazine-10-ethanamine, N,N,a-trimethyl- (9CI)
  • Isothipendyl (base and/or unspecified salts)
  • Adanton
  • Theruhistin
  • dimethyl-(1-methyl-2-pyrido[3,2-b][1,4]benzothiazin-10-yl-ethyl)amine
  • N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine
  • N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-2-amine
  • ISOTHIPENDYL
  • 10-(2-Dimethylaminopropyl)-10H-pyrido[3,2-b][1,4]benzothiazine
  • 10-(2-Dimethylaminopropyl)-1-Azaphenothiazine
  • 10H-Pyrido[3,2-b][1,4]benzothiazine, 10-[2-(dimethylamino)propyl]-
  • 10H-Pyrido[3,2-b][1,4]benzothiazine-10-ethanamine, N,N,alpha-trimethyl-
  • Andantol
  • Andanton
  • AY 56012
  • Dimethylaminoisopropylazaphenothiazine
  • N,N-Dimethyl-1-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)-2-propanamine
  • Nilergex
  • Odantol
  • Udantol
  • 10-(2-dimethylaminopropyl)pyrido(3,2-b)(1,4)benzothiazine
  • Vdantor
  • 10H-Pyrido[3,2-b][1,4]benzothiazine-10-ethanamine, N,N,α-trimethyl-
  • Isothipendyl USP/EP/BP
  • Isothipendylum
  • 482-15-5
  • C16H19N3S
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds