Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)

Product Name: Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)
CAS No.: 511254-92-5
Chemical Name: Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)
Synonyms: Alfacalcidol Impurity 12;(2S)-1-BENZYL-2-METHYLPIPERAZINE;(S)-1-Benzyl-2-methylpiperazine - [B91459];Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)-;Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)
CBNumber: CB31065342
Molecular Formula: C12H18N2
Formula Weight: 190.28
MOL File: 511254-92-5.mol

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Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI) Property

Boiling point:: 282℃
Density: 0.991
Flash point:: 112℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.29±0.40(Predicted)
Appearance: Brown to dark brown Liquid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB140528
Product name: (S)-1-Benzyl-2-methylpiperazine
Packaging: 250mg
Price: $72.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140528
Product name: (S)-1-Benzyl-2-methylpiperazine
Packaging: 1g
Price: $217
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140528
Product name: (S)-1-Benzyl-2-methylpiperazine
Packaging: 2g
Price: $377
Updated: 2021/12/16

Activate Scientific

Product number: AS41130
Product name: (S)-1-Benzyl-2-methylpiperazine
Purity: 95% ee
Packaging: 5G
Price: $470
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0000142
Product name: (S)-1-BENZYL-2-METHYL PIPERAZINE
Purity: 95.00%
Packaging: 5MG
Price: $503.36
Updated: 2021/12/16

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Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI) Chemical Properties,Usage,Production

Synthesis

716339-52-5

511254-92-5

Step 2: tert-Butyl (S)-4-benzyl-3-methylpiperazine-1-carboxylate (11.6 g, 40 mmol) was dissolved in dichloromethane (100 mL), trifluoroacetic acid (20 mL) was added slowly and the reaction mixture was stirred at room temperature for 30 minutes. Upon completion of the reaction, the reaction solution was concentrated to remove the solvent. Subsequently, the concentrate was dissolved in ice water and concentrated sodium hydroxide solution was added in batches to adjust the pH to above 13. The aqueous phase was extracted with ethyl acetate, the organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to afford (S)-1-benzyl-2-methylpiperazine (6.84 g, 90% yield), which could be used in the next reaction without further purification. Mass spectrum (ESI) m/z: 191.2 [M+H]+.

References

[1] Organic Letters, 2008, vol. 10, # 7, p. 1473 - 1476
[2] Patent: US2004/132711, 2004, A1. Location in patent: Page/Page column 16-17
[3] Patent: EP2952510, 2015, A1. Location in patent: Paragraph 0133
[4] Patent: US2009/270336, 2009, A1. Location in patent: Page/Page column 11-12
[5] Patent: US2005/261310, 2005, A1. Location in patent: Page/Page column 12-13; 29

Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI) Suppliers

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511254-92-5, Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)Related Search:

ecteinascidin 743 Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI) (1S,4S)-(+)-2-(2,4-DIFLUORO-BENZYL)-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE 2CF3COOH (1S,4S)-2-BENZYL-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE DI-TRIFLUORO-ACETIC ACID 2-(4-METHOXYBENZYL)-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE 2-(4-CHLOROBENZYL)-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE SNC 80 (1S,4S)-(+)-2-(4-TRIFLUOROMETHYL-BENZYL)-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE 2CF3COOH (R)-1-BENZYL-6-HYDROXYMETHYL-PIPERAZIN-2-ONE (1S,4S)-4-(2,5-DIAZA-BICYCLO[2.2.1]HEPT-2-YLMETHYL)-BENZONITRILE 2-(4-BROMOBENZYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE quinocarcin (1S,4S)-2-(3-CHLOROBENZYL)-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE 4-[(ALPHAR)-ALPHA-((2S,5R)-4-PROPYL-2,5-DEMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE 4-[(AR*)-ALPHA-((2S*,5R*)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-HYDROXYBENZYL]-N,N-DIETHYLBENZAMIDE (1S,4S)-2-(2,4-DIFLUOROBENZYL)-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE 3,8-Diazabicyclo(3.2.1)octane, 8-((alpha-carboxy)-p-toluoyl)-3-methyl- (1S,4S)-5-(PHENYLMETHYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE-2-CARBOXAMIDE

Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)- (9CI)

(2S)-1-BENZYL-2-METHYLPIPERAZINE

Piperazine, 2-methyl-1-(phenylmethyl)-, (2S)-

Alfacalcidol Impurity 12

(S)-1-Benzyl-2-methylpiperazine - [B91459]

511254-92-5

PIPERIDINE