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YM90Khydrochloride

Product Name
YM90Khydrochloride
CAS No.
154164-30-4
Chemical Name
YM90Khydrochloride
Synonyms
CS-885;YM 90K;YM-90K HCL;YM90Khydrochloride;6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-;6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione;1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedionehydrochloride;1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione monohydrochloride;2,3-Quinoxalinedione,1,4-dihydro-6-(1H-imidazol-1-yl)-7-nitro-,monohydrochloride;2,3-Quinoxalinedione,1,4-dihydro-6-(1H-imidazol-1-yl)-7-nitro-, hydrochloride (1:1)
CBNumber
CB31074818
Molecular Formula
C11H7N5O4.HCl
Formula Weight
0
MOL File
154164-30-4.mol
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YM90Khydrochloride Property

storage temp. 
Desiccate at RT
solubility 
Soluble to 10 mM in DMSO with gentle warming
form 
Powder
color 
Yellow to brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2701
Product name
YM90Khydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$255
Updated
2021/12/16
Tocris
Product number
2701
Product name
YM90Khydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$1019
Updated
2021/12/16
TRC
Product number
Y100610
Product name
YM90Khydrochloride
Packaging
10mg
Price
$250
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0000233
Product name
YM-90K
Purity
95.00%
Packaging
5MG
Price
$242
Updated
2021/12/16
ApexBio Technology
Product number
B7154
Product name
YM90Khydrochloride
Packaging
10mg
Price
$385
Updated
2021/12/16
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YM90Khydrochloride Chemical Properties,Usage,Production

Uses

YM 90K Hydrochloride is a selective AMPA receptor antagonist.

Biological Activity

Selective AMPA receptor antagonist (K i values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration.

in vivo

YM90K shows potent suppressive activity against audiogenic seizure in DBA/2 mice; ED50 values of YM90K against tonic seizure is 2.54 mg/kg (i.p.). The duration of the anticonvulsant effects of YM90K is 30 min[1].
In a global ischemia model, YM90K (15 mg/kg i.p.) significantly prevents the delayed neuronal death in the hippocampal CA1 region in Mongolian gerbils when administered 1 h after 5-min ischemia. The therapeutic time window for the neuroprotective effect of YM90K (30 mg/kg i.p.) is 6 h[1].
In a focal ischemia model, YM90K (30 mg/kg i.v. bolus+10 mg/kg/h for 4 h) reduces the volume of ischemic damage in the cerebral cortex in F344 rats[1].

YM90Khydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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YM90Khydrochloride Suppliers

China 41 Germany 1 South Korea 1 The Netherlands 1 United Kingdom 1 United States 9 USA 1 Global 55
Shanghai Boyle Chemical Co., Ltd.
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154164-30-4, YM90KhydrochlorideRelated Search:

Aluminum hydroxide

  • YM 90K
  • 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione monohydrochloride
  • YM-90K HCL
  • YM90Khydrochloride
  • 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione
  • 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedionehydrochloride
  • 2,3-Quinoxalinedione,1,4-dihydro-6-(1H-imidazol-1-yl)-7-nitro-,monohydrochloride
  • CS-885
  • 2,3-Quinoxalinedione,1,4-dihydro-6-(1H-imidazol-1-yl)-7-nitro-, hydrochloride (1:1)
  • 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-
  • anticonvulsant,AMPA,Inhibitor,ischemia,inhibit,neuroprotective,Ionotropic glutamate receptors,YM-90K,YM90K,iGluR
  • 154164-30-4
  • C11H7N5O4HCl