ChemicalBook > CAS DataBase List > JP1302

JP1302

Product Name: JP1302
CAS No.: 80259-18-3
Chemical Name: JP1302
Synonyms: JP1302;MMV006172;Brn 5117597;JP 1302 dihydrochloride;N-(4-(4-Methylpiperazin-1-yl)phenyl)acridin-9-amine;N-(4-(4-Methyl-1-piperazinyl)phenyl)-9-acridinamine;9-Acridinamine, N-(4-(4-methyl-1-piperazinyl)phenyl)-;JP1302(9-Acridinamine, N-[4-(4-methyl-1-piperazinyl)phenyl]-);N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinaminedihydrochloride
CBNumber: CB31075143
Molecular Formula: C24H24N4
Formula Weight: 368.47
MOL File: 80259-18-3.mol

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JP1302 Property

Boiling point:: 550.9±50.0 °C(Predicted)
Density: 1.227±0.06 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
pka: 9.03±0.10(Predicted)
Water Solubility: <44.14mg/ml in Water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2666
Product name: JP1302dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $233
Updated: 2021/12/16

Tocris

Product number: 2666
Product name: JP1302dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $980
Updated: 2021/12/16

Usbiological

Product number: 255566
Product name: JP 1302 dihydrochloride
Packaging: 10mg
Price: $480
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008021
Product name: JP 1302 DIHYDROCHLORIDE
Purity: 95.00%
Packaging: 10MG
Price: $727.65
Updated: 2021/12/16

ApexBio Technology

Product number: B7147
Product name: JP1302dihydrochloride
Packaging: 10mg
Price: $338
Updated: 2021/12/16

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JP1302 Chemical Properties,Usage,Production

Uses

JP 1302 Dihydrochloride is an α2-adrenoceptor blocker and can be used for the treatment or prevention of nephropathy.

Biological Activity

α 2C -adrenoceptor antagonist that displays ~ 50-fold selectivity over other α 2 -adrenoceptor subtypes (K i values are 28, 1470, 1700 and 3150 nM for human α 2C , α 2B , α 2D and α 2A subtypes respectively). Potently antagonizes adrenalin-stimulated 35 GTP γ S binding in vitro (K B = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo .

in vivo

JP1302 (1-10 μmol/kg) decreases immobility time in the FST to a level similar to that seen with 10-30 μmol/kg of the antidepressant Desipramine.html" class="link-product" target="_blank">Desipramine (HY-B1272A)^[1].
JP1302 (5 μmol/kg, once) is capable of complete reversal of the impairment in PPI induced in Sprague-Dawley rats by the psychotomimetic NMDA receptor antagonist, phencyclidine and similar results are found in Wistar rats^[1].
JP1302 (3 mg/kg, IV, once) significantly ameliorates renal dysfunction^[3].

Animal Model:	Male Sprague Dawley rats (8 weeks old)^[3]
Dosage:	3 mg/kg
Administration:	IV, pre-treatment: administered 5 min before the induction of ischemia, post-treatment: injected 45 min after the initiation of reperfusion
Result:	Significantly ameliorated renal dysfunction in the rats at 24 h after reperfusion. post-ischemic administration of JP-1302 significantly ameliorated renal dysfunction, histological damage and reduced apoptotic cells and pro-inflammatory cytokine mRNA expression.

IC 50

human α2C-adrenoceptor: 28±2 nM (Ki); human α2B-adrenoceptor: 1470±130 nM (Ki); human α2A-adrenoceptor: 3150±50 nM (Ki); rodent α2D-adrenoceptor: 1700±200 nM (Ki)

JP1302 Preparation Products And Raw materials

Raw materials

Preparation Products

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JP1302 Suppliers

China 39 Germany 1 United Kingdom 1 United States 7 Global 48

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80259-18-3, JP1302Related Search:

JP1302 4-(9-acridinylamino)aniline

JP1302

9-Acridinamine, N-(4-(4-methyl-1-piperazinyl)phenyl)-

Brn 5117597

N-(4-(4-Methyl-1-piperazinyl)phenyl)-9-acridinamine

JP 1302 dihydrochloride

N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinaminedihydrochloride

JP1302(9-Acridinamine, N-[4-(4-methyl-1-piperazinyl)phenyl]-)

MMV006172

N-(4-(4-Methylpiperazin-1-yl)phenyl)acridin-9-amine

80259-18-3

C24H24N42HCl

Potently antagonizes adrenalin-stimulated 35GTPγS binding in vitro (KB = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo.