2-Pyrimidinamine, N-(1-methylethyl)- (9CI)
- Product Name
- 2-Pyrimidinamine, N-(1-methylethyl)- (9CI)
- CAS No.
- 4214-72-6
- Chemical Name
- 2-Pyrimidinamine, N-(1-methylethyl)- (9CI)
- Synonyms
- Isaxonine;2-(Isopropylamino)pyrimidine;N-Isopropylpyrimidin-2-amine;N-Isopropyl-2-pyrimidinamine;2-(N-isopropylamino)pyrimidine;isopropyl(pyrimidin-2-yl)amine;N-(Isopropylamino)-2-pyrimidine;2-Pyrimidinamine, N-(1-methylethyl)-;2-Pyrimidinamine, N-(1-methylethyl)- (9CI)
- CBNumber
- CB31081355
- Molecular Formula
- C7H11N3
- Formula Weight
- 137.18
- MOL File
- 4214-72-6.mol
2-Pyrimidinamine, N-(1-methylethyl)- (9CI) Property
- Melting point:
- 27-28℃
- Boiling point:
- 229℃
- Density
- 1.065
- Flash point:
- 93℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Colourless Semi-Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I900670
- Product name
- Isaxonine
- Packaging
- 100mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- I900670
- Product name
- Isaxonine
- Packaging
- 1g
- Price
- $715
- Updated
- 2021/12/16
- Product number
- CHM0303805
- Product name
- 2-(ISOPROPYLAMINO)PYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.29
- Updated
- 2021/12/16
- Product number
- 46951
- Product name
- Isaxonine
- Packaging
- 1g
- Price
- $1460
- Updated
- 2021/12/16
- Product number
- FI63880
- Product name
- Isopropyl-pyrimidin-2-yl-amine
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
2-Pyrimidinamine, N-(1-methylethyl)- (9CI) Chemical Properties,Usage,Production
Originator
Nerfactor,Ipsen,France,1981
Uses
Isaxonine is a neurotropic agent. Isaxonine prevents synaptic remodeling by suppression of the redundant nerve endings from additional axons. Isaxonine is transformed by cytochrome P 450 into reactive metabolites that lead to immunoallergic hepatitis in man.
Definition
ChEBI: Isaxonine is an aminopyrimidine.
Manufacturing Process
6 liters of ethanol and 685 g (5 mold of 2-isopropylamino pyrimidine were added to a 10 liter reactor and stirred. To the solution were added 600 g (5.2 mols) of phosphoric acid and the mixture was boiled under reflux for one hour. There was obtained a dark green solution which was treated with 30 g of carbon black. After separation and crystallization while stirring overnight, the crystallized product was separated, washed with ethanol and dried at 50°C. There was obtained 1,027 g (87% yield) of a white powder melting at 125°C. The analysis of the compound showed a good correspondence with the formula C7H14O4N3P.
brand name
Nerfactor;Verfactor.
Therapeutic Function
Neurotropic
World Health Organization (WHO)
Isaxonine phosphate was introduced in 1981 and marketed exclusively in France for the treatment of peripheral neuropathy. In January 1983 indications for use were restricted following its association with cases of toxic hepatitis. It was subsequently withdrawn in June 1983.
2-Pyrimidinamine, N-(1-methylethyl)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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