ChemicalBook > CAS DataBase List > 4-Pyrimidinamine, 2-chloro-N-methyl- (9CI)

4-Pyrimidinamine, 2-chloro-N-methyl- (9CI)

Product Name
4-Pyrimidinamine, 2-chloro-N-methyl- (9CI)
CAS No.
66131-68-8
Chemical Name
4-Pyrimidinamine, 2-chloro-N-methyl- (9CI)
Synonyms
2-Chloro-N-methylpyridin-4-amine;2-chloro-N-methyl-4-pyridinamine;2-Chloro-4-(methylamino)pyrimidine;2-chloro-n-methylpyrimidin-4-amine;2-chloro-N-methylpyrimidine-4-amine;4-Pyrimidinamine, 2-chloro-N-methyl-;(2-Chloro-pyrimidin-4-yl)-methyl-amine;4-Pyrimidinamine, 2-chloro-N-methyl- (9CI);2-chloro-N-methylpyrimidin-4-amine(SALTDATA: FREE);4-Pyrimidinamine, 2-chloro-N-methyl- (9CI) ISO 9001：2015 REACH
CBNumber
CB31081845
Molecular Formula
C5H6ClN3
Formula Weight
143.57
MOL File
66131-68-8.mol
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4-Pyrimidinamine, 2-chloro-N-methyl- (9CI) Property

storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41-43
Safety Statements 
26-36/37-39
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C428853
Product name
2-Chloro-N-methylpyrimidin-4-amine
Packaging
500mg
Price
$155
Updated
2021/12/16
Apolloscientific
Product number
OR18111
Product name
2-Chloro-4-(methylamino)pyrimidine
Packaging
1g
Price
$160
Updated
2021/12/16
BroadPharm
Product number
BP-20444
Product name
2-chloro-N-methylpyrimidin-4-amine
Purity
96%
Packaging
1g
Price
$98
Updated
2021/12/16
AK Scientific
Product number
0156AC
Product name
2-Chloro-N-methylpyrimidin-4-amine
Packaging
1g
Price
$141
Updated
2021/12/16
SynQuest Laboratories
Product number
3H31-5-76
Product name
2-Chloro-4-(methylamino)pyrimidine
Packaging
1g
Price
$176
Updated
2021/12/16
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4-Pyrimidinamine, 2-chloro-N-methyl- (9CI) Chemical Properties,Usage,Production

Synthesis

3934-20-1

74-89-5

66131-68-8

Synthesis of 2-chloro-N-methylpyrimidin-4-amine (18): 2,4-dichloropyrimidine (5.0 g, 33.79 mmol) was dissolved in anhydrous THF (50 mL), and a THF solution of 2.0 M methylamine (42.2 mL, 84.48 mmol) was slowly added at -40 °C. The reaction mixture was stirred at 0 °C for 4 hours. After completion of the reaction, the mixture was partitioned between CHCl3/2-propanol (4:1) and water. The organic layer was dried over anhydrous sodium sulfate, filtered through a CELITE pad and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 100% dichloromethane) to afford 2-chloro-N-methylpyrimidin-4-amine (2.8 g, 58% yield) as a white solid. Retention time (Rt) = 1.15 min; 1H NMR (600 MHz, DMSO-d6) δ 8.02 (s, 1H), 6.22 (m, 1H), 2.86 (d, J=4.8 Hz, 3H) ppm; mass spectrum (MS) m/z: 144.12 [M+1].

References

[1] Patent: WO2016/23014, 2016, A2. Location in patent: Paragraph 00412-00413
[2] Patent: US2010/261727, 2010, A1. Location in patent: Page/Page column 30
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3510 - 3513
[4] Patent: WO2009/97474, 2009, A1. Location in patent: Page/Page column 26-27
[5] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 5, p. 1349 - 1356

4-Pyrimidinamine, 2-chloro-N-methyl- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Pyrimidinamine, 2-chloro-N-methyl- (9CI) manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Pyrimidinamine, 2-chloro-N-methyl- (9CI) 66131-68-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons
Release date
2021-05-12

66131-68-8, 4-Pyrimidinamine, 2-chloro-N-methyl- (9CI)Related Search:

2-CHLORO-4-(N,N-DIMETHYLAMINO)PYRIMIDINE CRIMIDINE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-METHYLBENZAMIDE CCPA 4-(m-aminoanilino)-2,5,6-trichloropyrimidine N-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-N'-[4-(TRIFLUOROMETHOXY)PHENYL]UREA N-(4-CHLOROPHENYL)-N'-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)UREA N-benzyl-2-chloro-5-nitropyrimidin-4-amine 2-[(2-chloropyrimidin-4-yl)amino]ethanol N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-CHLOROBENZENE-1-SULFONAMIDE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-3-(TRIFLUOROMETHYL)BENZAMIDE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-METHYLBENZENE-1-SULFONAMIDE CHEMBRDG-BB 5145935 N4,6-DIMETHYL-N4-PHENYL-2-CHLORO-5-NITROPYRIMIDIN-4-AMINE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-(TRIFLUOROMETHYL)BENZENE-1-SULFONAMIDE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-FLUOROBENZAMIDE N-PHENYL-N'-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)UREA

  • 4-Pyrimidinamine, 2-chloro-N-methyl- (9CI)
  • 2-chloro-n-methylpyrimidin-4-amine
  • 2-Chloro-N-methylpyridin-4-amine
  • 2-chloro-N-methylpyrimidin-4-amine(SALTDATA: FREE)
  • 2-Chloro-4-(methylamino)pyrimidine
  • 2-chloro-N-methyl-4-pyridinamine
  • (2-Chloro-pyrimidin-4-yl)-methyl-amine
  • 2-chloro-N-methylpyrimidine-4-amine
  • 4-Pyrimidinamine, 2-chloro-N-methyl-
  • 4-Pyrimidinamine, 2-chloro-N-methyl- (9CI) ISO 9001：2015 REACH
  • 66131-68-8
  • PYRIMIDINE
  • Amines
  • Pyrazines, Pyrimidines & Pyridazines
  • Pyrazines, Pyrimidines & Pyridazines