4-Pyrimidinamine, 5-methoxy- (9CI)
- Product Name
- 4-Pyrimidinamine, 5-methoxy- (9CI)
- CAS No.
- 695-86-3
- Chemical Name
- 4-Pyrimidinamine, 5-methoxy- (9CI)
- Synonyms
- 5-Methoxy-4-pyrimidinamine;4-amino-5-methoxypyrimdine;5-MethoxypyriMidin-4-aMine;4-Amino-5-methoxypyrimidine;4-Pyrimidinamine, 5-methoxy-;4-Pyrimidinamine, 5-methoxy- (9CI);4-Pyrimidinamine, 5-methoxy- (9CI) ISO 9001：2015 REACH
- CBNumber
- CB31081870
- Molecular Formula
- C5H7N3O
- Formula Weight
- 125.13
- MOL File
- 695-86-3.mol
4-Pyrimidinamine, 5-methoxy- (9CI) Property
- Melting point:
- 118.5-119.0 °C
- Boiling point:
- 264.3±20.0 °C(Predicted)
- Density
- 1.224±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 5.04±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M333035
- Product name
- 5-Methoxypyrimidin-4-amine
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 119933
- Product name
- 5-Methoxypyrimidin-4-amine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $274
- Updated
- 2021/12/16
- Product number
- 4H30-1-25
- Product name
- 5-Methoxy-4-pyrimidinamine
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- CHM0314776
- Product name
- 4-AMINO-5-METHOXYPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.18
- Updated
- 2021/12/16
- Product number
- 119933
- Product name
- 5-Methoxypyrimidin-4-amine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $684
- Updated
- 2021/12/16
4-Pyrimidinamine, 5-methoxy- (9CI) Chemical Properties,Usage,Production
Synthesis
695-85-2
695-86-3
General procedure for the synthesis of 4-amino-5-methoxypyrimidines from 4-chloro-5-methoxypyrimidines: 4-chloro-5-methoxypyrimidines (I-89) (40 g, 280 mmol) was suspended in NH3(g)/EtOH (4 M, 2000 mL), the suspension was transferred to an autoclave, and the reaction was stirred for 12 hours at 130 °C. The progress of the reaction was monitored by TLC (unfolding agent: CH2Cl2/MeOH = 10:1) and after confirming the completion of the reaction, the reaction mixture was cooled to room temperature. Subsequently, the mixture was concentrated under vacuum to obtain the residue. CH2Cl2 (100 mL) was added to the residue and stirred at room temperature for 30 minutes. The reaction mixture was filtered to remove the NH4Cl salt and the filtrate was concentrated under vacuum to give the crude product. The crude product was stirred with a solvent mixture of EtOAc/CH2Cl2 (50 mL, 4:1) for 30 min, filtered and concentrated in vacuum to give the final 4-amino-5-methoxypyrimidine (I-90) (30 g, 87% yield) as a yellow solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.01 (s, 1H), 7.81 (s, 1H), 6.75 (br.s., 2H), 3.81 (s, 3H).
References
[1] Patent: WO2016/97918, 2016, A1. Location in patent: Page/Page column 80
[2] Organic Process Research and Development, 2015, vol. 19, # 6, p. 639 - 645
[3] European Journal of Medicinal Chemistry, 2009, vol. 44, # 10, p. 4179 - 4191
4-Pyrimidinamine, 5-methoxy- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
View Lastest Price from 4-Pyrimidinamine, 5-methoxy- (9CI) manufacturers
- Product
- 4-Pyrimidinamine, 5-methoxy- (9CI) 695-86-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-13
- Product
- 4-Pyrimidinamine, 5-methoxy- (9CI) 695-86-3
- Price
- US $0.00/kg
- Min. Order
- 200kg
- Purity
- ≥99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-08
- Product
- 4-Pyrimidinamine, 5-methoxy- (9CI) 695-86-3
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-03-13