Methylthiouracil

Product Name: Methylthiouracil
CAS No.: 56-04-2
Chemical Name: Methylthiouracil
Synonyms: MZU;Mtu;Thyril;Alkiron;Basecil;Muracil;Muracin;Orcanon;Thioryl;Thiuryl
CBNumber: CB3108758
Molecular Formula: C5H6N2OS
Formula Weight: 142.18
MOL File: 56-04-2.mol

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Methylthiouracil Property

Melting point:: ~330 °C (dec.)(lit.)
Density: 1.291 (estimate)
refractive index: 1.6430 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Heated), Methanol (Slightly, Heated)
pka: pKa 8.2 (Uncertain)
form: Liquid
color: Clear colorless to yellow
Water Solubility: INSOLUBLE
Merck: 14,6128
BRN: 115648
Stability:: Incompatible with strong oxidizing agents, iodine, metals.
InChIKey: HWGBHCRJGXAGEU-UHFFFAOYSA-N
CAS DataBase Reference: 56-04-2(CAS DataBase Reference)
NIST Chemistry Reference: 6-Methyl-2-thiouracil(56-04-2)
IARC: 2B (Vol. Sup 7, 79) 2001
EPA Substance Registry System: Methylthiouracil (56-04-2)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-40
Safety Statements: 36/37-45
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
RTECS: YR0875000
Hazard Note: Irritant/Possible Carcinogen
TSCA: Yes
HS Code: 29335995
Hazardous Substances Data: 56-04-2(Hazardous Substances Data)
Toxicity: MLD in rabbits (mg/kg): 2486 orally (Simon)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 69400
Product name: 6-Methyl-2-thiouracil
Purity: purum, ≥98.0% S basis (elemental analysis)
Packaging: 100g
Price: $113
Updated: 2024/03/01

Sigma-Aldrich

Product number: 69400
Product name: 6-Methyl-2-thiouracil
Purity: purum, ≥98.0% S basis (elemental analysis)
Packaging: 500g
Price: $202
Updated: 2023/06/20

TCI Chemical

Product number: M0443
Product name: 6-Methyl-2-thiouracil
Purity: >98.0%(T)
Packaging: 25g
Price: $22
Updated: 2024/03/01

TCI Chemical

Product number: M0443
Product name: 6-Methyl-2-thiouracil
Purity: >98.0%(T)
Packaging: 500g
Price: $264
Updated: 2024/03/01

Alfa Aesar

Product number: A17982
Product name: 6-Methyl-2-thiouracil, 98%
Packaging: 50g
Price: $23.1
Updated: 2023/06/20

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Methylthiouracil Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

antithyroid agent

Uses

6-?Methyl-?2-?thiouracil is a derivative of methylthiouracil (M330710), a competitive inhibitor of Nitric Oxide Synthase (NOS). Potential anti-inflammatory agent.

Definition

ChEBI: Methylthiouracil is a pyrimidone.

General Description

White crystalline powder with an odor of onions and a bitter taste. A saturated aqueous solution is neutral or slightly acidic.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Methylthiouracil reacts with strong oxidizing agents. Forms complexes with metals and is oxidized by iodine and other sulfhydryl oxidizing agents .

Fire Hazard

Flash point data for Methylthiouracil are not available. Methylthiouracil is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human teratogenic and reproductive effects by an unspecified route: developmental abnormalities of the endocrine system and effects on newborn including neonatal measures or effects. Experimental reproductive effects. Used to treat hyperthyroidism. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Purification Methods

Crystallise the thiouracil from a large volume of H2O. Purify it further by dissolving in base, adding charcoal, filtering and acidifying with AcOH. Suspend the wet solid (ca 100g) in boiling H2O (1L), stir and add AcOH (20mL), stir and refrigerate. Collect the product, wash it with cold H2O (4 x 200mL), drain it for several hours then place it in an oven at 70o to constant weight. [IR: Short & Thompson J Chem Soc 168 1952, Foster & Snyder Org Synth Coll Vol IV 638 1063, Beilstein 24 III/IV 1289.]

Methylthiouracil Preparation Products And Raw materials

Raw materials

Sodium oxide Sodium carbonate

Preparation Products

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Methylthiouracil Suppliers

Americas 1 Austria 1 Belgium 2 China 328 Europe 2 Germany 8 India 14 Japan 4 Slovakia 1 Switzerland 2 United Kingdom 12 United States 39 Global 414

Chemspon Bio-Tech Co., Ltd

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ProdList: 242
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Jiangxi Puxin Biotechnology Co., Ltd

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Tai 'an Huanyu Chemical Co., LTD

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Country: China
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J & K SCIENTIFIC LTD.

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INTATRADE GmbH

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3B Pharmachem (Wuhan) International Co.,Ltd.

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future industrial shanghai co., ltd

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ProdList: 1995
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View Lastest Price from Methylthiouracil manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Methylthiouracil 56-04-2
Price: US $556.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 1T
Release date: 2020-07-17

Hebei Weibang Biotechnology Co., Ltd

Product: Methylthiouracil 56-04-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2021-09-16

Hebei Mojin Biotechnology Co., Ltd

Product: Methylthiouracil 56-04-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-17

56-04-2, MethylthiouracilRelated Search:

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4-OXO-2-MERCAPTO-6-METHYLPYRIMIDINE

4-HYDROXY-2-MERCAPTO-6-METHYLPYRIMIDINE

4-HYDROXY-6-METHYL-2-THIOPYRIMIDINE

4-METHYL-2-THIOURACIL

4(6)-METHYL-2-THIOURACIL

AKOS BC-0693

6-METHYL-4-OXY-2-THIOPYRIMIDINE

6-METHYL-2-THIOURACIL

6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-4-ONE

6-methyl-2-thioxo-2,3-dihydro-1h-pyrimidin-4-one

6-HYDROXY-2-MERCAPTO-4-METHYLPYRIMIDINE

2,3-dihydro-6-methyl-2-thioxo-4(1h)-pyrimidinon

2,3-Dihydro-6-methyl-2-thioxo-4(1H)-pyrimidinone

2-THIO-6-METHYLURACIL

6-METHYL-2-THIOURACYLE

Methylthiouracilum

6-METHYL-2-THIOURACILE VETRANAL, 250

4-METHYL-2-THIOURACIL 98%

4(1H)-Pyrimidinone, 2,3-dihydro-6-methyl-2-thioxo- (9CI)

6-METHYL-2-THIOURACIL,REAGENT

6 methyl2 thiouracile

methylthiouracil，MTU

4-Hydroxy-2-mercapto 6-methylpyrimidine, 6-Methyl-2-thiouracil

6-Methyl-2-sulfanylidene-1H-pyrimidin-4-one

4-Hydroxy-2-mercapto-6-methylpyrimidine,98%

6-methyl-2-thioxo-1H-pyrimidin-4-one

MZU

6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

6-Methyl-2-thiouracil,4-Hydroxy-2-mercapto 6-methylpyrimidine, MZU

4-Hydroxy-2-mercapto-6-methylpyrimidine,4-Hydroxy-2-mercapto 6-methylpyrimidine, 6-Methyl-2-thiouracil, MZU

6-Methyl-2-thioxo-2,3-dihydropyriMidin-4(1H)-one (Methylthiouracil)

6-Methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-one, 4-Hydroxy-2-mercapto-6-methylpyrimidine

4-Hydroxy-2-Mercapto-6-MethylpyriMidin

2,3-Dihydro-6-methyl-2-thioxopyrimidin-4(1H)-one, 4-Hydroxy-2-mercapto-6-methylpyrimidine

2-Mercapto-6-methylpyrimidin-4(1H)-one

2-Mercapto-4-hydroxy-6-methylpyrimidine

2-Mercapto-6-methyl-4-pyrimidone

2-Mercapto-6-methylpyrimid-4-one

2-Thio-4-oxo-6-methyl-1,3-pyrimidine

2-Thio-6-methyl-1,3-pyrimidin-4-one

2-Thiouracil, 6-methyl-

4(1H)-Pyrimidinone, 2,3-dihydro-6-methyl-2-thioxo-

4-Methylthiouracil

6-Methyl-2-thiouracil puruM, >=98.0% S basis (eleMental analysis)

Methyl thiourea pyriMidine

6-Methyl-2-thi

6-Methyl-2-mercaptouracil

6-Methyl-2-thio-2,4(1H,3H)-pyrimidinedione

6-methyl-2-thio-2,4-(1h3h)-pyrimidinedione

6-methyl-2-thio-uraci

6-Methyl-2-thiouracyl

6-Methyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone

6-Methylthiouracil

6-Metil-tiouracile