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Methylthiouracil

Product Name
Methylthiouracil
CAS No.
56-04-2
Chemical Name
Methylthiouracil
Synonyms
MZU;Mtu;Thyril;Alkiron;Basecil;Muracil;Muracin;Orcanon;Thioryl;Thiuryl
CBNumber
CB3108758
Molecular Formula
C5H6N2OS
Formula Weight
142.18
MOL File
56-04-2.mol
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Methylthiouracil Property

Melting point:
~330 °C (dec.)(lit.)
Density 
1.291 (estimate)
refractive index 
1.6430 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Heated), Methanol (Slightly, Heated)
pka
pKa 8.2 (Uncertain)
form 
Liquid
color 
Clear colorless to yellow
Water Solubility 
INSOLUBLE
Merck 
14,6128
BRN 
115648
Stability:
Incompatible with strong oxidizing agents, iodine, metals.
InChIKey
HWGBHCRJGXAGEU-UHFFFAOYSA-N
CAS DataBase Reference
56-04-2(CAS DataBase Reference)
NIST Chemistry Reference
6-Methyl-2-thiouracil(56-04-2)
IARC
2B (Vol. Sup 7, 79) 2001
EPA Substance Registry System
Methylthiouracil (56-04-2)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-40
Safety Statements 
36/37-45
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
YR0875000
Hazard Note 
Irritant/Possible Carcinogen
TSCA 
Yes
HS Code 
29335995
Hazardous Substances Data
56-04-2(Hazardous Substances Data)
Toxicity
MLD in rabbits (mg/kg): 2486 orally (Simon)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
69400
Product name
6-Methyl-2-thiouracil
Purity
purum, ≥98.0% S basis (elemental analysis)
Packaging
100g
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
69400
Product name
6-Methyl-2-thiouracil
Purity
purum, ≥98.0% S basis (elemental analysis)
Packaging
500g
Price
$202
Updated
2023/06/20
TCI Chemical
Product number
M0443
Product name
6-Methyl-2-thiouracil
Purity
>98.0%(T)
Packaging
25g
Price
$22
Updated
2024/03/01
TCI Chemical
Product number
M0443
Product name
6-Methyl-2-thiouracil
Purity
>98.0%(T)
Packaging
500g
Price
$264
Updated
2024/03/01
Alfa Aesar
Product number
A17982
Product name
6-Methyl-2-thiouracil, 98%
Packaging
50g
Price
$23.1
Updated
2023/06/20
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Methylthiouracil Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

antithyroid agent

Uses

6-?Methyl-?2-?thiouracil is a derivative of methylthiouracil (M330710), a competitive inhibitor of Nitric Oxide Synthase (NOS). Potential anti-inflammatory agent.

Definition

ChEBI: Methylthiouracil is a pyrimidone.

General Description

White crystalline powder with an odor of onions and a bitter taste. A saturated aqueous solution is neutral or slightly acidic.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Methylthiouracil reacts with strong oxidizing agents. Forms complexes with metals and is oxidized by iodine and other sulfhydryl oxidizing agents .

Fire Hazard

Flash point data for Methylthiouracil are not available. Methylthiouracil is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human teratogenic and reproductive effects by an unspecified route: developmental abnormalities of the endocrine system and effects on newborn including neonatal measures or effects. Experimental reproductive effects. Used to treat hyperthyroidism. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Purification Methods

Crystallise the thiouracil from a large volume of H2O. Purify it further by dissolving in base, adding charcoal, filtering and acidifying with AcOH. Suspend the wet solid (ca 100g) in boiling H2O (1L), stir and add AcOH (20mL), stir and refrigerate. Collect the product, wash it with cold H2O (4 x 200mL), drain it for several hours then place it in an oven at 70o to constant weight. [IR: Short & Thompson J Chem Soc 168 1952, Foster & Snyder Org Synth Coll Vol IV 638 1063, Beilstein 24 III/IV 1289.]

Methylthiouracil Preparation Products And Raw materials

Raw materials

Sodium oxide Sodium carbonate

Preparation Products

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View Lastest Price from Methylthiouracil manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Methylthiouracil 56-04-2
Price
US $556.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
1T
Release date
2020-07-17
Hebei Weibang Biotechnology Co., Ltd
Product
Methylthiouracil 56-04-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2021-09-16
Hebei Mojin Biotechnology Co., Ltd
Product
Methylthiouracil 56-04-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-17

56-04-2, MethylthiouracilRelated Search:

Pirimiphos-methyl 2-Thiouracil 1-PHENYL-2-THIOUREA Methyl acetate Dihydromyrcenol CHLOROPHOSPHONAZO III Methylparaben Propylthiouracil 4-Hydroxypyrimidine Mercaptoacetic acid N-Aminothiourea Methyl acrylate Kresoxim-methyl Bensulfuron methyl Thiophanate-methyl Sulfamerazine METHYL THIOPHENE-2-CARBOXYLATE 2-Ethylhexyl mercaptoacetate

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