ChemicalBook > CAS DataBase List > 2-BROMONICOTINIC ACID ETHYL ESTER

2-BROMONICOTINIC ACID ETHYL ESTER

Product Name: 2-BROMONICOTINIC ACID ETHYL ESTER
CAS No.: 53087-78-8
Chemical Name: 2-BROMONICOTINIC ACID ETHYL ESTER
Synonyms: Ethyl 2-bromonicotinate;Ethyl2-bromonicotinate,96%;ethyl 2-broMopyridine-3-carboxylate;2-bromo-3-pyridinecarboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 2-bromo-, ethyl ester
CBNumber: CB31091813
Molecular Formula: C8H8BrNO2
Formula Weight: 230.06
MOL File: 53087-78-8.mol

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2-BROMONICOTINIC ACID ETHYL ESTER Property

Boiling point:: 271℃
Density: 1.501
Flash point:: 118℃
storage temp.: Inert atmosphere,Room Temperature
pka: -1.14±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: E903443
Product name: Ethyl2-Bromonicotinate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 126618
Product name: Ethyl2-bromonicotinate
Purity: >95%
Packaging: 5g
Price: $1224
Updated: 2021/12/16

Matrix Scientific

Product number: 126618
Product name: Ethyl2-bromonicotinate
Purity: >95%
Packaging: 1g
Price: $396
Updated: 2021/12/16

AK Scientific

Product number: Y9350
Product name: Ethyl2-bromonicotinate
Packaging: 1g
Price: $584
Updated: 2021/12/16

Abosyn

Product number: 61-2951
Product name: Ethyl2-bromonicotinate
Purity: 95%-98%
Packaging: 0.25g
Price: $620
Updated: 2021/12/16

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2-BROMONICOTINIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 2066, 1976 DOI: 10.1021/jo00873a051

Synthesis

105-56-6

927-63-9

53087-78-8

Ethyl cyanoacetate (59 mL, 0.5 mol) and 1-dodecyl-3-methylimidazolium chloride (50 mL) were added to the reactor, followed by 3-dimethylaminoacrylate (62 mL, 0.5 mol) and stirred well. The reaction mixture was heated to 90 °C in an oil bath and kept at this temperature for 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent: petroleum ether/dichloromethane = 1:2, color developer: iodine vapor), and after confirming the complete reaction of 3-dimethylaminobenzaldehyde, the reaction mixture was cooled to room temperature. The reaction mixture was extracted three times with 1,2-dichloroethane (60 mL) and the organic phases were combined. The aqueous phase was washed with deionized water, dried under vacuum and recycled. Dry hydrogen bromide (HBr) gas was passed into the organic phase until completion of the reaction was confirmed by high performance liquid chromatography (HPLC). The pH of the reaction mixture was adjusted to 5-6 with 20% sodium carbonate solution and then the aqueous phase was extracted with 1,2-dichloroethane (20 mL x 3). The organic layers were combined, dried over molecular sieves, filtered and the solvent was evaporated under reduced pressure to recover 1,2-dichloroethane to give ethyl 2-bromonicotinate (108.4 g, light brown liquid) in 94.0% yield.

References

[1] Patent: CN105001154, 2017, B. Location in patent: Paragraph 0049; 0050; 0051; 0052
[2] Patent: CN104945317, 2018, B. Location in patent: Paragraph 0047; 0048

2-BROMONICOTINIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-BROMONICOTINIC ACID ETHYL ESTER manufacturers

Career Henan Chemical Co

Product: 2-BROMONICOTINIC ACID ETHYL ESTER 53087-78-8
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

53087-78-8, 2-BROMONICOTINIC ACID ETHYL ESTERRelated Search:

Nicotinic acid ETHYL STEARATE 2-Bromo-3-pyridinecarboxylic acid methyl ester 2-BROMONICOTINIC ACID ETHYL ESTER 2-Bromonicotinic acid 2-BROMO-3-(HYDROXYMETHYL)PYRIDINE TERT-BUTYL-2-BROMONICOTINATE 2-BROMO-3-FORMYLPYRIDINE

Ethyl 2-bromonicotinate

ethyl 2-broMopyridine-3-carboxylate

2-bromo-3-pyridinecarboxylic acid ethyl ester

3-Pyridinecarboxylic acid, 2-bromo-, ethyl ester

Ethyl2-bromonicotinate,96%

53087-78-8