1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE
- Product Name
- 1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE
- CAS No.
- 424792-57-4
- Chemical Name
- 1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE
- Synonyms
- EOS-60469;3,4-Difluorophenyl Methyl Sulfone;3,4-Difluorophenyl methyl sulphone;3,4-DifluorophenylMethylSulfone>1,2-difluoro-4-methanesulfonyl-benzene;1,2-Difluoro-4-(methylsulphonyl)benzene;Benzene, 1,2-difluoro-4-(methylsulfonyl)-
- CBNumber
- CB31096393
- Molecular Formula
- C7H6F2O2S
- Formula Weight
- 192.18
- MOL File
- 424792-57-4.mol
1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE Property
- Melting point:
- 71°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Light yellow
Safety
- HS Code
- 2930909899
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- MNO000024
- Product name
- 1,2-Difluoro-4-(methylsulfonyl)benzene
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- D4526
- Product name
- 3,4-Difluorophenyl Methyl Sulfone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- D4526
- Product name
- 3,4-Difluorophenyl Methyl Sulfone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $128
- Updated
- 2025/07/31
- Product number
- D448633
- Product name
- 1,2-Difluoro-4-methylsulfonylbenzene
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- D448633
- Product name
- 1,2-Difluoro-4-methylsulfonylbenzene
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE Chemical Properties,Usage,Production
Uses
1,2-Difluoro-4-methylsulfonylbenzene
Synthesis
75-75-2
367-11-3
424792-57-4
Step 1: Synthesis of 1,2-difluoro-4-methanesulfonylbenzene; a mixture of thionyl chloride (12.73 mL, 0.175 mol) and methanesulfonic acid (28.4 mL, 0.438 mol) was heated and refluxed overnight, and subsequently cooled to 80 °C. At this temperature, 1,2-difluorobenzene (8.64 mL, 88 mmol) and trifluoromethanesulfonic acid (0.675 mL, 8.8 mmol) were added dropwise. The reaction mixture was continued to be heated at 120 °C for 3 h, after which it was cooled to room temperature and poured into ice water (200 mL). The mixture was extracted three times with ethyl acetate, the organic extracts were combined and dried over sodium sulfate, filtered and the solvent evaporated. The product was purified by fast chromatography using 15% ethyl acetate/hexane as eluent to afford 1,2-difluoro-4-methylsulfonylbenzene (9.98 g, 59% yield) as a white solid.1H NMR (300 MHz, CDCl3) δ 3.27 (s, 3H), 7.70-7.84 (m, 2H), 8.02-8.09 (m, 1H).
References
[1] Patent: US2009/286812, 2009, A1. Location in patent: Page/Page column 18
[2] Patent: WO2007/54668, 2007, A1. Location in patent: Page/Page column 8-9; 10-11
1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
1,2-DIFLUORO-4-(METHYLSULFONYL)BENZENE Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75