ChemicalBook > CAS DataBase List > 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
- Product Name
- 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
- CAS No.
- 76041-73-1
- Chemical Name
- 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
- Synonyms
- 3-Bromo-2-hydroxy-5-(trifL;3-Bromo-5-(trifluoromethyl)pyridin-2-ol;3-bromo-5-(trifluoromethyl)pyridine-2-ol;3-Bromo-5-(Trifluoromethyl)pyridin-2-ylol;3-bromo-5-(trifluoromethyl)-1h-pyridin-2-one;3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine;2(1H)-Pyridinone,3-bromo-5-(trifluoromethyl)-;2-Hydroxy-3-bromo-5-(trifluoromethyl)pyridine;3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine98%;3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine 98%
- CBNumber
- CB31107291
- Molecular Formula
- C6H3BrF3NO
- Formula Weight
- 241.99
- MOL File
- 76041-73-1.mol
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3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine Property
- Boiling point:
- 252.7±40.0 °C(Predicted)
- Density
- 1.876±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 8.06±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B696278
- Product name
- 3-Bromo-2-hydroxy-5-trifluoromethylpyridine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC7971
- Product name
- 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 026739
- Product name
- 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $25
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H01-B-X0
- Product name
- 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $26
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC7971
- Product name
- 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $29
- Updated
- 2021/12/16
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3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine Chemical Properties,Usage,Production
Synthesis
33252-63-0
76041-73-1
General procedure for the synthesis of 2-hydroxy-3-bromo-5-trifluoromethylpyridine from 2-hydroxy-5-trifluoromethylpyridine: to a solution of 5-(trifluoromethyl)pyridin-2-ol (10.52 g, 62 mmol) and sodium acetate (5.29 g, 64 mmol) in glacial acetic acid (38 mL) was added slowly with bromine (3.36 mL, 65 mmol) and the reaction was at room temperature. The reaction was carried out at room temperature. After observing the gradual transformation of the white turbid solution into a clarified brown solution, the reaction mixture was heated and refluxed at 80 °C for 2.5 h. After the reaction was completed, the mixture was cooled and refluxed for 2.5 h. The reaction was carried out at room temperature. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently removed by evaporation under reduced pressure. The residue was neutralized with saturated sodium bicarbonate solution to pH=8. The neutralized aqueous phase was extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product 15.1 g (99.8% yield) as a white solid. The purity of the product was confirmed by LC-MS with a calculated value of [M+H]+ of C6H3BrF3NO of 241.9 and a measured value of 241.9/243.9.
References
[1] Patent: US2005/267146, 2005, A1. Location in patent: Page/Page column 22-23
[2] Patent: WO2004/82682, 2004, A1. Location in patent: Page 47-48
[3] Patent: WO2004/94371, 2004, A2. Location in patent: Page 59
[4] Patent: US2008/81803, 2008, A1. Location in patent: Page/Page column 25
[5] Patent: US2007/117797, 2007, A1. Location in patent: Page/Page column 23
3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine 76041-73-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
Henan Fengda Chemical Co., Ltd
- Product
- 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine 76041-73-1
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
Dideu Industries Group Limited
- Product
- 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine 76041-73-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
76041-73-1, 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridineRelated Search:
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