Dopropidil
- Product Name
- Dopropidil
- CAS No.
- 79700-61-1
- Chemical Name
- Dopropidil
- Synonyms
- 4205CERM;Dopropidil;Pyrrolidine, 1-[1-[(2-methylpropoxy)methyl]-2-[[1-(1-propyn-1-yl)cyclohexyl]oxy]ethyl]-
- CBNumber
- CB31116828
- Molecular Formula
- C20H35NO2
- Formula Weight
- 321.501
- MOL File
- 79700-61-1.mol
Dopropidil Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- API0011271
- Product name
- DOPROPIDIL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.75
- Updated
- 2021/12/16
- Product number
- CSN21615
- Product name
- Dopropidil
- Packaging
- 5mg
- Price
- $612
- Updated
- 2021/12/16
- Product number
- CSN21615
- Product name
- Dopropidil
- Packaging
- 25mg
- Price
- $1835
- Updated
- 2021/12/16
Dopropidil Chemical Properties,Usage,Production
Uses
Dopropidil is a novel anti-anginal calcium ion modulating agent, possessing intracellular calcium antagonist activity and anti-ischemic effects in several predictive animal models.
in vivo
Dopropidil (1 and 2.5 mg/kg) dose-dependently reduces the electrical (ST segment elevation), biochemical (lactate production and potassium release), and mechanical (loss in myocardial segment contractility) perturbations induced by ischemia in the anesthetized dog. Intraduodenal administration of Dopropidil (50 mg/kg) significantly reduces isoproterenol-induced tachycardia. This effect is manifest at 15-120 min following administration of the compound which indicates a rapid absorption and a long duration of action. In conscious dogs Dopropidil (12-14 mg/kg p.o.) reduces resting heart rate by approximately10 beats/min[1].
References
[1] J. Planellas, et al. Dopropidil, A Novel Antianginal Calcium Modulating Agent. Cardiovascular Drug Reviews. Vol.12, No.3, pp. 208-224.
Dopropidil Preparation Products And Raw materials
Raw materials
Preparation Products
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