ChemicalBook > CAS DataBase List > Nepicastat

Nepicastat

Product Name
Nepicastat
CAS No.
173997-05-2
Chemical Name
Nepicastat
Synonyms
SYN117;CS-853;Nepitat;Nepicastat;RS-25560-197;Nepicastat HCl;Nepicastat [inn];Nepicastat (SYN 117);Nepicastat (free base) (SYN-117);SYN117;RS-25560-197;SYN-117;SYN 117
CBNumber
CB31116989
Molecular Formula
C14H15F2N3S
Formula Weight
295.35
MOL File
173997-05-2.mol
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Nepicastat Property

Boiling point:
401.8±55.0 °C(Predicted)
Density 
1.40
storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 48 mg/mL (162.52 mM)
form 
Powder
pka
11.69±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
474143
Product name
Nepicastat
Packaging
100mg
Price
$1890
Updated
2021/12/16
Matrix Scientific
Product number
093133
Product name
(S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1H-imidazole-2(3H)-thione
Purity
95+%
Packaging
250mg
Price
$5670
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000869
Product name
NEPICASTAT
Purity
95.00%
Packaging
250MG
Price
$8610
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000869
Product name
NEPICASTAT
Purity
95.00%
Packaging
1G
Price
$9435.2
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000869
Product name
NEPICASTAT
Purity
95.00%
Packaging
10MG
Price
$1006.58
Updated
2021/12/16
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Nepicastat Chemical Properties,Usage,Production

Uses

Treatment of congestive heart failure (dopamine β-hydroxylase inhibitor).

Definition

ChEBI: Nepicastat is a member of the class of 1,3-dihydroimidazole-2-thiones that is 1,3-dihydro-2H-imidazole-2-thione in which one of the nitrogens is substituted by a 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl group while the carbon adjacent to it is substituted by an aminomethyl group (the S enantiomer). It is a potent and selective inhibitor of both bovine and human dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. It has a role as an EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor. It is a member of tetralins, an organofluorine compound, a primary amino compound and a member of 1,3-dihydroimidazole-2-thiones.

target

DBH

Nepicastat Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nepicastat manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Nepicastat 173997-05-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Nepicastat 173997-05-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
Nepicastat 173997-05-2
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-20

173997-05-2, NepicastatRelated Search:


  • Nepicastat
  • Nepicastat [inn]
  • 5-(AMinoMethyl)-1-((S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthyl)-4-iMidazoline-2-thione
  • 5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione
  • RS-25560-197
  • SYN117
  • Nepicastat (free base) (SYN-117)
  • Nepicastat HCl
  • (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1H-imidazole-2(3H)-thione
  • (S)-5-Aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-2,3-dihydro-2-thioxo-1H-imidazole Hydrochloride
  • (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1H-imidazole-2(3H)-thi
  • Nepitat
  • SYN117;RS-25560-197;SYN-117;SYN 117
  • CS-853
  • Nepicastat (SYN 117)
  • 2H-Imidazole-2-thione, 5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-
  • 173997-05-2
  • C14H15F2N3S
  • API