Siccanin
- Product Name
- Siccanin
- CAS No.
- 22733-60-4
- Chemical Name
- Siccanin
- Synonyms
- Siccanin;Sicanina;Siccanine;NSC 135048;Siccaninum;CS 280, SI 23548;Siccanin USP/EP/BP;Sicanina [inn-spanish];Siccanine [inn-french];1,2,3,4,4a,5,6,6a,11b,13b-Decahydro-4,4,6a,9-tetramethyl-13H-benzo[a]furo[2,3,4-mn]xanthen-11-ol
- CBNumber
- CB31120733
- Molecular Formula
- C22H30O3
- Formula Weight
- 342.47
- MOL File
- 22733-60-4.mol
Siccanin Property
- Melting point:
- 139-140°
- alpha
- D20 -136° (c = 2 in chloroform)
- Boiling point:
- 427.8±45.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
- form
- A solid
- pka
- 10.9(at 25℃)
Safety
- Toxicity
- LD50 in mice, rats (mg/kg): >6000, >1000 orally; >3000, >600 s.c. or i.p. (Suzuki)
N-Bromosuccinimide Price
- Product number
- 23654
- Product name
- Siccanin
- Purity
- >98%
- Packaging
- 1mg
- Price
- $310
- Updated
- 2024/03/01
- Product number
- 23654
- Product name
- Siccanin
- Purity
- ≥98%
- Packaging
- 5 mg
- Price
- $1082
- Updated
- 2024/03/01
- Product number
- 23654
- Product name
- Siccanin
- Purity
- >98%
- Packaging
- 500μg
- Price
- $168
- Updated
- 2022/04/27
- Product number
- S497055
- Product name
- Siccanin
- Packaging
- 1mg
- Price
- $230
- Updated
- 2021/12/16
- Product number
- S497055
- Product name
- Siccanin
- Packaging
- 2.5mg
- Price
- $460
- Updated
- 2021/12/16
Siccanin Chemical Properties,Usage,Production
Description
Siccanin is an inhibitor of mitochondrial complex II (succinate dehydrogenase; IC50s = 0.87 and 9.3 μM for P. aeruginosa and rat mitochondria, respectively). It inhibits the growth of T. mentagrophytes (IC50 = 0.3 μg/ml) via inhibition of succinate oxidation in the mitochondria. It also inhibits the growth of C. albicans strains with IC50 values ranging from 5-40 and 80-90 μg/ml for aerobic and anaerobic conditions, respectively.
Uses
Siccanin is an unusual, fused, phenolic pentacycle first isolated from Helminthosporium siccans and reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.
Uses
Siccanin is an antifungal and SDHB (IP) inhibitor.
Definition
ChEBI: Siccanin is an organic heteropentacyclic compound. It has a role as an antifungal drug and a fungal metabolite.
Origin
Siccanin was found in the culture broth of Helminthosporium siccans by Sankyo Co. in 1962.
Biological Activity
Siccanin shows specific and strong ac tivity against the dermatophytes Trichophyton, Epidermophyton, and Microsporum, but ithas almost no activity against other fungi.
Siccanin Preparation Products And Raw materials
Raw materials
Preparation Products
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- 400-400-6206333 18521732826
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View Lastest Price from Siccanin manufacturers
- Product
- Siccanin 22733-60-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-19