ChemicalBook > CAS DataBase List > (S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID

(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID

Product Name
(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID
CAS No.
210354-22-6
Chemical Name
(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID
Synonyms
GW274150;GW274150 (GW-274150;Acetylcysteine Impurity 4;4-(2-acetamidoethylthio)-2-aminobutanoic acid;S-[2-[(1-iminoethyl)amino]ethyl]-L-Homocysteine;4-(2-acetamidoethylsulfanyl)-2-aminobutanoicacid;L-Homocysteine, S-[2-[(1-iminoethyl)amino]ethyl]-;(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID;(2S)-2-amino-4-[(2-ethanimidamidoethyl)sulfanyl]butanoic acid
CBNumber
CB3116696
Molecular Formula
C8H17N3O2S
Formula Weight
219.3
MOL File
Mol file
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(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID Property

Boiling point:
392.3±52.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
form 
Solid
pka
2.22±0.10(Predicted)
color 
White to off-white
Water Solubility 
Water : ≥ 62 mg/mL (282.72 mM)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5419
Product name
GW274150
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-5419
Product name
GW274150
Packaging
10mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-5419
Product name
GW274150
Packaging
25mg
Price
$700
Updated
2021/12/16
ChemScene
Product number
CS-5419
Product name
GW274150
Packaging
50mg
Price
$1000
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611586
Product name
GW274150
Packaging
100mg
Price
$1208.7
Updated
2021/12/16
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(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID Chemical Properties,Usage,Production

Uses

GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 exerts a protective role in an acute model of lung injury inflammation[1][2].

in vivo

GW274150 is a long-acting (5 h half-life in rats) iNOS inhibitor and is able to inhibit LPS-mediated increase in plasma NO2-, NO3- levels 14 h after single intraperitoneal dose (ED50=3 mg/kg)[2].GW274150 (intraperitoneal injection; 2.5, 5, and 10 mg/kg; before carrageenan injection) reduces the degree of lung injury induced by carrageenan in a dose-related fashion. Oedema formation and PMNs infiltration in the pleural cavity are also significantly attenuated in a dose-related manner in rats[2].GW274150 (oral adminstration; 30 mg/kg; twice daily; 7 days) leads to significant neuroprotection, However, it displays a bell-shaped neuroprotective profile, being ineffective at high doses in 6-OHDA rat model of Parkinson disease (PD)[3].

Animal Model:SD-rat[2]
Dosage:2.5, 5 and 10 mg/kg; single dose
Administration:Intraperitonealinjection 5 min before carrageenan injection
Result:Exerted a protective role in an acute model of inflammation, carrageenan-induced lung injury.

IC 50

iNOS

References

[1] Alderton WK, et al. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.Br J Pharmacol. 2005 Jun;145(3):301-12. DOI:10.1038/sj.bjp.0706168
[2] Dugo L, et al. Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation. Br J Pharmacol. 2004 Mar;141(6):979-87. Epub 2004 Feb DOI:10.1038/sj.bjp.0705683
[3] Broom L, et al. Neuroprotectionby theselectiveiNOSinhibitorGW274150in amodelofParkinsondisease.Free Radic Biol Med.2011 Mar 1;50(5):633-40. DOI:10.1016/j.freeradbiomed.2010.12.026

(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID Suppliers

China 40 India 1 Italy 1 Switzerland 1 United Kingdom 1 United States 4 Global 48
Guangzhou Younan Technology Co., Ltd
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Shanghai Synmedia Chemical Co., Ltd.
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0531-85828981
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+86-531-85806006
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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Amadis Chemical Company Limited
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Musechem
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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Suzhou Rovathin Foreign Trade Co.,Ltd
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TargetMol Chemicals Inc.
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210354-22-6, (S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACIDRelated Search:


  • S-[2-[(1-iminoethyl)amino]ethyl]-L-Homocysteine
  • GW274150
  • (S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID
  • Acetylcysteine Impurity 4
  • 4-(2-acetamidoethylthio)-2-aminobutanoic acid
  • GW274150 (GW-274150
  • L-Homocysteine, S-[2-[(1-iminoethyl)amino]ethyl]-
  • 4-(2-acetamidoethylsulfanyl)-2-aminobutanoicacid
  • (2S)-2-amino-4-[(2-ethanimidamidoethyl)sulfanyl]butanoic acid
  • 210354-22-6