(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID
- Product Name
- (S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID
- CAS No.
- 210354-22-6
- Chemical Name
- (S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID
- Synonyms
- GW274150;GW274150 (GW-274150;Acetylcysteine Impurity 4;4-(2-acetamidoethylthio)-2-aminobutanoic acid;S-[2-[(1-iminoethyl)amino]ethyl]-L-Homocysteine;4-(2-acetamidoethylsulfanyl)-2-aminobutanoicacid;L-Homocysteine, S-[2-[(1-iminoethyl)amino]ethyl]-;(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID;(2S)-2-amino-4-[(2-ethanimidamidoethyl)sulfanyl]butanoic acid
- CBNumber
- CB3116696
- Molecular Formula
- C8H17N3O2S
- Formula Weight
- 219.3
- MOL File
- Mol file
(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID Property
- Boiling point:
- 392.3±52.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- form
- Solid
- pka
- 2.22±0.10(Predicted)
- color
- White to off-white
- Water Solubility
- Water : ≥ 62 mg/mL (282.72 mM)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-5419
- Product name
- GW274150
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-5419
- Product name
- GW274150
- Packaging
- 10mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- API0013934
- Product name
- GW-274150
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.85
- Updated
- 2021/12/16
- Product number
- CS-5419
- Product name
- GW274150
- Packaging
- 25mg
- Price
- $700
- Updated
- 2021/12/16
- Product number
- CS-5419
- Product name
- GW274150
- Packaging
- 50mg
- Price
- $1000
- Updated
- 2021/12/16
(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID Chemical Properties,Usage,Production
Uses
GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 exerts a protective role in an acute model of lung injury inflammation[1][2].
in vivo
GW274150 is a long-acting (5 h half-life in rats) iNOS inhibitor and is able to inhibit LPS-mediated increase in plasma NO2-, NO3- levels 14 h after single intraperitoneal dose (ED50=3 mg/kg)[2].GW274150 (intraperitoneal injection; 2.5, 5, and 10 mg/kg; before carrageenan injection) reduces the degree of lung injury induced by carrageenan in a dose-related fashion. Oedema formation and PMNs infiltration in the pleural cavity are also significantly attenuated in a dose-related manner in rats[2].GW274150 (oral adminstration; 30 mg/kg; twice daily; 7 days) leads to significant neuroprotection, However, it displays a bell-shaped neuroprotective profile, being ineffective at high doses in 6-OHDA rat model of Parkinson disease (PD)[3].
| Animal Model: | SD-rat[2] |
| Dosage: | 2.5, 5 and 10 mg/kg; single dose |
| Administration: | Intraperitonealinjection 5 min before carrageenan injection |
| Result: | Exerted a protective role in an acute model of inflammation, carrageenan-induced lung injury. |
IC 50
iNOS
References
[1] Alderton WK, et al. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.Br J Pharmacol. 2005 Jun;145(3):301-12. DOI:10.1038/sj.bjp.0706168
[2] Dugo L, et al. Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation. Br J Pharmacol. 2004 Mar;141(6):979-87. Epub 2004 Feb DOI:10.1038/sj.bjp.0705683
[3] Broom L, et al. Neuroprotectionby theselectiveiNOSinhibitorGW274150in amodelofParkinsondisease.Free Radic Biol Med.2011 Mar 1;50(5):633-40. DOI:10.1016/j.freeradbiomed.2010.12.026
(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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