Butopamine
- Product Name
- Butopamine
- CAS No.
- 66734-12-1
- Chemical Name
- Butopamine
- Synonyms
- LY-131126;Butopamine;Compound LY-131126;4-[(R)-3-[[(R)-2-(4-Hydroxyphenyl)-2-hydroxyethyl]amino]butyl]phenol;(R)-4-Hydroxy-α-[[(R)-3-(4-hydroxyphenyl)-1-methylpropylamino]methyl]benzyl alcohol;Benzenemethanol, 4-hydroxy-α-[[[(1R)-3-(4-hydroxyphenyl)-1-methylpropyl]amino]methyl]-, (αR)-
- CBNumber
- CB31178198
- Molecular Formula
- C18H23NO3
- Formula Weight
- 301.38
- MOL File
- 66734-12-1.mol
Butopamine Property
- Boiling point:
- 520.5±50.0 °C(Predicted)
- Density
- 1.189±0.06 g/cm3(Predicted)
- pka
- 9.97±0.26(Predicted)
N-Bromosuccinimide Price
- Product number
- API0010911
- Product name
- BUTOPAMINE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $550.2
- Updated
- 2021/12/16
Butopamine Chemical Properties,Usage,Production
Originator
Butopamine,ZYF Pharm Chemical
Definition
ChEBI: A 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol in which both stereocentres have R configuration. It is the most active of the four diastereoisomers that make up the animal feed additive ractopamine.
Manufacturing Process
A solution of 32.8 g (0.2 m) of methyl 2-(4-hydroxyphenyl)ethyl ketone and
42.6 g (0.2 m) of 1-(4-hydroxyphenyl)-2-aminoethanol in 380 ml of ethanol containing 3.8 g of 5% palladium on carbon was stirred for 16 h at 60°C
under hydrogen at 55 psi. The reaction mixture was then filtered, and the
filtrate was diluted by addition of 350 ml of water. The aqueous mixture was
concentrated to a volume of about 400 ml, and then washed with
dichloromethane.
The aqueous mixture was acidified by addition of 50 ml of conc. hydrochloric
acid. After standing at room temperature for 2 h, the aqueous acid mixture
was filtered and the filter cake was washed with 40 ml of ice water and dried
at 50°C in vacuum to provide 47.0 g of 1-(4-hydroxyphenyl-2-
propylamino]ethanol hydrochloride, melting point 124-129°C.
The 1-(4-hydroxyphenyl)-2-[1-methyl-3-(4-hydroxyphenyl)propylamino]
ethanol was obtained by treatment of 1-(4-hydroxyphenyl-2-
propylamino]ethanol hydrochloride with sodium hydroxide.
Therapeutic Function
Cardiotonic
Butopamine Preparation Products And Raw materials
Raw materials
Preparation Products
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