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Clobenztropine

Product Name
Clobenztropine
CAS No.
5627-46-3
Chemical Name
Clobenztropine
Synonyms
Clobenztropine;3-(4-Chlorophenylphenylmethoxy)tropane;3α-[(4-Chlorophenyl)phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane;8-Azabicyclo[3.2.1]octane, 3-[(4-chlorophenyl)phenylmethoxy]-8-methyl-
CBNumber
CB31178330
Molecular Formula
C21H24ClNO
Formula Weight
341.87
MOL File
5627-46-3.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0011086
Product name
CLOBENZTROPINE
Purity
95.00%
Packaging
5MG
Price
$496.3
Updated
2021/12/16
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Clobenztropine Chemical Properties,Usage,Production

Originator

Clobenztropine,Onbio Inc.

Definition

ChEBI: 3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane is a diarylmethane.

Manufacturing Process

A solution of 28.2 g (0.2 mol) of 3-tropanol is prepared in 50 ml of xylol, and to this solution is added 23.8 g (0.1 mol) of 4-chlorobenzhydryl chloride. The resultant solution is heated for 7 h at 145°-155°C, following which the mixture is cooled and filtered. The clear filtrate thus obtained is washed with 50 ml of 5% aqueous potassium carbonate solution and then with three successive 25 ml portion of water. The xylol solution is then extracted with three successive 50 ml portions of 2 N hydrochloric acid. The xylol layer is discarded and the acid extracts are combined and rendered strongly basic by the addition of 22.5% aqueous potassium hydroxide, resulting in the formation of an oily base which separates and which is then extracted with
benzol, from which the benzol is evaporated to yield crude 3-(4'- chlorobenzhydryloxy)tropane as a brown oil.
2.0 g of 3-(4'-chlorobenzhydryloxy)tropane is treated with 10 ml of 4.5 N isopropanoic acid hydrogen chloride solution, and the pasty mixture which results is diluted with approximately 30 ml of absolute ether. A solid product is formed which is separated by filtration and then washed with absolute ether. The product is then purified by dissolving it in hot isopropanol, followed by clarification with activated charcoal. Upon cooling the filtrate, the 3-(4'- chlorophenylbenzyloxy)tropane separates as a crystalline powder, melting point 215°-217°C.
In practice it is usually used as hydrochloride.

Therapeutic Function

Antihistaminic

Clobenztropine Preparation Products And Raw materials

Raw materials

Preparation Products

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Clobenztropine Suppliers

Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
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58
Hubei Nordina Biotechnology Co., Ltd.
Tel
19371278702
Fax
18162687220
Email
nuodinashengwu@163.com
Country
China
ProdList
971
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58
Hubei huizepu Pharmaceutical Technology Co., Ltd
Tel
023-19371278 19371278702
Email
n13164103386@163.com
Country
China
ProdList
3277
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58
Jilin Chinese Academy of Sciences-yanshen Technology
Tel
+undefined18143011203
Email
info@chemextension.com
Country
China
ProdList
42056
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58
Lanospharma Laboratories Co.,Ltd
Tel
--
Fax
--
Email
sales@lanospharma.com
Country
China
ProdList
6329
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56

5627-46-3, ClobenztropineRelated Search:


  • Clobenztropine
  • 3-(4-Chlorophenylphenylmethoxy)tropane
  • 3α-[(4-Chlorophenyl)phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane
  • 8-Azabicyclo[3.2.1]octane, 3-[(4-chlorophenyl)phenylmethoxy]-8-methyl-
  • 5627-46-3