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Clortermine

Product Name
Clortermine
CAS No.
10389-73-8
Chemical Name
Clortermine
Synonyms
Chlortermine;o-Chlorophentermine;2-Chloro-α,α-dimethylbenzeneethanamine;Benzeneethanamine, 2-chloro-α,α-dimethyl-;1-(2-chlorophenyl)-2-methylpropan-2-amine;1-(2-Chlorophenyl)-2-methyl-2-propaneamine;1-(2-chlorophenyl)-2-methyl-propan-2-amine;[2-(2-chlorophenyl)-1,1-dimethyl-ethyl]amine
CBNumber
CB31178365
Molecular Formula
C10H14ClN
Formula Weight
183.68
MOL File
10389-73-8.mol
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Clortermine Property

Boiling point:
bp16 116-118°
Density 
1.074±0.06 g/cm3(Predicted)
pka
9.60±0.25(Predicted)
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Safety

Hazardous Substances Data
10389-73-8(Hazardous Substances Data)
DEA Controlled Substances
CSCN: 1647
CSA SCH: Schedule III
NARC: No
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0123072
Product name
1-(2-CHLOROPHENYL)-2-METHYLPROPAN-2-AMINE
Purity
95.00%
Packaging
5MG
Price
$499.57
Updated
2021/12/16
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Clortermine Chemical Properties,Usage,Production

Originator

Voranil,U.S.V.,US,1973

Uses

Anorexic.

Definition

ChEBI: Clortermine is a member of amphetamines.

Manufacturing Process

To a Grignard reagent (prepared from 50.0 g of o,α-dichloro-toluene and 7.45 g of magnesium in diethyl ether) is added 18.0 g of acetone at such rate that constant reflux is maintained. The reaction mixture is allowed to stand overnight at room temperature, and is then poured onto a mixture of 20% sulfuric acid and ice. The organic layer is separated, washed with water, an aqueous solution of sodium hydrogen carbonate and again with water, dried over magnesium sulfate and evaporated to dryness. The residue is distilled under reduced pressure to yield 42.6 g of 1-(o-chlorophenyl)-2-methyl-2- propanol, BP 120° to 122°C/12.5 mm.
To 29.0 ml of glacial acetic acid, cooled to 15°C, is added 11.5 g of sodium cyanide (98%) while stirring, and then dropwise 32.4 ml of concentrated sulfuric acid, dissolved in 29 ml of glacial acetic acid, while maintaining a temperature of 20°C. The 1-(o-chlorophenyl)-2-methyl-2-propanol is added moderately fast, allowing the temperature to rise spontaneously. After completing the addition, the reaction mixture is heated to 70°C and stirred, and is then poured onto a mixture of water and ice. The aqueous mixture is neutralized with sodium carbonate and extracted with diethyl ether. The organic solution is washed with water, dried over magnesium sulfate and evaporated to dryness.
The oily residue is taken up in 100 ml of 6 N aqueous hydrochloric acid and refluxed until a clear solution is obtained. The latter is made basic with aqueous ammonia and extracted with diethyl ether; the organic solution is separated, washed, dried and evaporated. The residue is distilled under reduced pressure to yield 26.3 g of 1-(o-chlorophenyl)-2-methyl-2- propylamine, BP 116° to 118°C/16 mm.
The 1-(o-chlorophenyl)-2-methyl-2-propylamine hydrochloride is prepared by adding ethanolic hydrogen chloride to an ice-cold solution of the free base in ethanol; the desired salt precipitates and is recrystallized from ethanol, MP 245° to 246°C.

Therapeutic Function

Antiobesity

Clortermine Preparation Products And Raw materials

Raw materials

Preparation Products

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Clortermine Suppliers

Henan Pumei Jihua Pharmaceutical Technology Co., Ltd.
Tel
037188900765 18037465274
Fax
QQ3430974218
Email
enyawanglei@sina.cn
Country
China
ProdList
13747
Advantage
58
Shaanxi Didu New Materials Co. Ltd
Tel
+86-89586680 +86-13289823923
Email
1026@dideu.com
Country
China
ProdList
8670
Advantage
58