Intoplicine
- Product Name
- Intoplicine
- CAS No.
- 125974-72-3
- Chemical Name
- Intoplicine
- Synonyms
- Intoplicine;7H-Benzo[e]pyrido[4,3-b]indol-3-ol, 11-[[3-(dimethylamino)propyl]amino]-8-methyl-;11-(3-Dimethylaminopropylamino)-3-hydroxy-8-methyl-7H-benzo[e]pyrido[4,3-b]indole
- CBNumber
- CB31178956
- Molecular Formula
- C21H24N4O
- Formula Weight
- 348.44
- MOL File
- 125974-72-3.mol
Intoplicine Property
- Melting point:
- 216-218 °C
- Boiling point:
- 635.5±55.0 °C(Predicted)
- Density
- 1.286±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 8.26±0.30(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- API0011668
- Product name
- INTOPLICINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.89
- Updated
- 2021/12/16
- Product number
- CSN21689
- Product name
- Intoplicine
- Packaging
- 5mg
- Price
- $3529
- Updated
- 2021/12/16
Intoplicine Chemical Properties,Usage,Production
Uses
Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA[1][2].
Definition
ChEBI: Intoplicine is a pyridoindole.
in vivo
At the highest non-toxic dose (HNTD) (6 mg/kg/injection, total dose, 36 mg/kg), Intoplicine shows highly active with a T/C of 0% and a corresponding total log cell kill of 3[3].
IC 50
Topoisomerase I; Topoisomerase II
References
[1] Eckardt JR, et al. Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst. 1994 Jan 5;86(1):30-3. DOI:10.1093/jnci/86.1.30
[2] Morjani H, et al. Molecular and cellular interactions between Intoplicine, DNA, and topoisomerase II studied by surface-enhanced Raman scattering spectroscopy. Cancer Res. 1993 Oct 15;53(20):4784-90. PMID:8402662
[3] Bissery MC, et al. Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice. Invest New Drugs. 1993;11(4):263-277. DOI:10.1007/BF00874425
Intoplicine Preparation Products And Raw materials
Raw materials
Preparation Products
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