Proadifen
- Product Name
- Proadifen
- CAS No.
- 302-33-0
- Chemical Name
- Proadifen
- Synonyms
- D011335;Sk 525a;RP-5171;HL-8727;Proadifenum;Glycine Impurity 21;Hydrochloride, proadifen;Diethylaminoethyldiphenylpropyl acetate;Acetate, diethylaminoethyldiphenylpropyl;2,2-Diphenylvaleric acid 2-(diethylamino)ethyl
- CBNumber
- CB31179579
- Molecular Formula
- C23H31NO2
- Formula Weight
- 353.5
- MOL File
- 302-33-0.mol
Proadifen Property
- Boiling point:
- 486.9°C (rough estimate)
- Density
- 1.0678 (rough estimate)
- refractive index
- 1.5614 (estimate)
- pka
- 9.20±0.25(Predicted)
- EPA Substance Registry System
- Benzeneacetic acid, .alpha.-phenyl-.alpha.-propyl-, 2-(diethylamino)ethyl ester (302-33-0)
Safety
- Toxicity
- LDLo oral in rat: 500mg/kg
N-Bromosuccinimide Price
- Product number
- API0008740
- Product name
- PROADIFEN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.79
- Updated
- 2021/12/16
Proadifen Chemical Properties,Usage,Production
Uses
Synergist (non-specific).
Definition
ChEBI: 2,2-diphenylpentanoic acid 2-(diethylamino)ethyl ester is a diarylmethane.
Enzyme inhibitor
This nonselective P450 inhibitor (FWfree-base = 353.50 g/mol; CAS 302-33-0; 62-68-0 for the HCl salt), also known as SKF-525A, b-diethylaminoethyl 2,2-diphenylpropylacetate, and N,N-diethylaminoethyl 2,2- diphenylvalerate, blocks glibenclamide-sensitive K+ channels, including ATP-sensitive inward rectifier potassium channel 8 (KIR6.1). As a nonselective inhibitor of cytochrome P450 systems, proadifen also inhibits drug metabolism, thereby potentiating the action of many pharmaceuticals. For example, proadifen inhibits the demethylation of 2-methoxyestrogens . Target (s) : aldehyde oxidase; alkanal monooxygenase, FMN- linked; aromatase, or CYP19; bacterial luciferase, or alkanal monooxygenase, FMN-linked; benzoate 4-monooxygenase; bromomethane monooxygenase7; calcium influx8; ent-copalyl-diphosphate synthase; CYPC211; cytochrome P450; diamine N- acetyltransferase; N,N-dimethylaniline demethylase; ecdysone 20- monooxygenase; ethoxyresorufin O-deethylase; flavin-containing monooxygenase, or dimethylaniline-N-oxide aldolase; glyceollin synthase; 2-hydroxyisoflavanone synthase; 25-hydroxyvitamin D3 24-monooxygenase; isopentenyl-diphosphate D-isomerase, or isopentenyl-pyrophosphate D-isomerase; ent-kaurene synthase; leukotriene B4 20-hydroxylase; (S) -limonene 3-monooxygenase; (S) -limonene 6-monooxygenase; (S) -limonene 7-monooxygenase; methane monooxygenase; monoamine oxidase; NADPH:cytochrome P450 reductase; nitric-oxide synthase, neuronal ; pentoxyresorufin O-depentylase; phenol O-methyltransferase ; progesterone 11a-monooxygenase; steroid 11b-monooxygenase ; steroid 21-monooxygenase, or CYP21A1, weakly inhibited; sterol 14-demethylase, or CYP51; styrene monooxygenase; thiol S-methyltransferase; thromboxane production; and trimethylamine-oxide aldolase.
Proadifen Preparation Products And Raw materials
Raw materials
Preparation Products
Proadifen Suppliers
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