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Zindoxifene

Product Name
Zindoxifene
CAS No.
86111-26-4
Chemical Name
Zindoxifene
Synonyms
D-16726;Zindoxifene;4-(5-acetoxy-1-ethyl-3-methyl-1H-indol-2-yl)phenyl acetate;2-[4-(Acetyloxy)phenyl]-1-ethyl-3-methyl-1H-indol-5-ol acetate;1H-Indol-5-ol, 2-[4-(acetyloxy)phenyl]-1-ethyl-3-methyl-, 5-acetate
CBNumber
CB31180100
Molecular Formula
C21H21NO4
Formula Weight
351.4
MOL File
86111-26-4.mol
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Zindoxifene Property

Melting point:
146-147 °C(Solv: ethanol (64-17-5))
Boiling point:
508.3±50.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0012823
Product name
ZINDOXIFENE
Purity
95.00%
Packaging
5MG
Price
$501.66
Updated
2021/12/16
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Zindoxifene Chemical Properties,Usage,Production

Originator

Zindoxifene,GASTHAUS

Definition

ChEBI: Zindoxifene is a phenylindole.

Manufacturing Process

At 70°C there were added BBr 3 with the injector into a solution of 1-methyl-2- (4-methoxy-phenyl)-6-methoxy-1-ethylindole in water free methylene chloride. After 30 min the cold bath was removed and the mixture stirred overnight. The reaction mixture is carefully poured into a saturated sodium bicarbonate solution with ice cooling. The product is extracted three times with ethyl acetate, the combined organic extracts washed with sodium bicarbonate solution and water, dried and the solvent removed on a rotary evaporator. The 3-methyl-2-(4-hydroxyphenyl)-6-hydroxy-1-ethylindole was produced, melting point 142-143°C.
There are added acetic anhydride and of pyridine to the thus obtained 3- methyl-2-(4-hydroxyphenyl)-6-hydroxy-1-ethylindole and the mixture heated for 2 h at the boiling point. After cooling the mixture is poured onto ice, extracted with methylene chloride and the organic phase washed twice with 2 N HCl. After drying and removal of solvent in the rotary evaporator the residue is chromatographed with methylene chloride via silica and subsequently 3-methyl-2-(4-acetoxyphenyl)-6-acetoxy-1-ethylindole is obtained, melting point 150-152°C (recrystallized from ethanol).

Therapeutic Function

Antiestrogen

Zindoxifene Preparation Products And Raw materials

Raw materials

Preparation Products

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Zindoxifene Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19711
Advantage
58

86111-26-4, ZindoxifeneRelated Search:


  • Zindoxifene
  • 2-[4-(Acetyloxy)phenyl]-1-ethyl-3-methyl-1H-indol-5-ol acetate
  • D-16726
  • 4-(5-acetoxy-1-ethyl-3-methyl-1H-indol-2-yl)phenyl acetate
  • 1H-Indol-5-ol, 2-[4-(acetyloxy)phenyl]-1-ethyl-3-methyl-, 5-acetate
  • 86111-26-4