ChemicalBook > CAS DataBase List > Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-

Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-

Product Name: Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-
CAS No.: 2272904-53-5
Chemical Name: Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-
Synonyms: TAK 279;Zasocitinib;NDI-034858(Zasocitinib);Zasocitinib，NDI-034858，TAK 279;N-[(1R,2R)-2-Methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo-2H-[1,2’-bipyridin]-3-yl)amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide;N-((1R,2R)-2-methoxycyclobutyl)-7-(methylamino)-5-((2-oxo-2H-[1,2'-bipyridin]-3-yl)amino)pyrazolo[1,5-a]pyrimidine-3-carboxamide;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-;N-((1R,2R)-2-Methoxy-cyclobutyl)-7-(methylamino)-5-((2-oxo-2H-[1,2'-bipyridin]-3-yl)amino)-1H-pyrazolo[1,5-a]pyrimidine-3-carboxamide
CBNumber: CB311944341
Molecular Formula: C23H24N8O3
Formula Weight: 460.49
MOL File: 2272904-53-5.mol

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Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Property

Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Acetonitrile: Soluble
DMSO: Soluble
form: Solid
pka: 10.37±0.40(Predicted)
color: Off-white to light yellow
InChIKey: BWINBHTTZLVXGT-NVXWUHKLSA-N
SMILES: C12=C(C(N[C@@H]3CC[C@H]3OC)=O)C=NN1C(NC)=CC(NC1=CC=CN(C3=NC=CC=C3)C1=O)=N2

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Hazard and Precautionary Statements (GHS)

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Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Chemical Properties,Usage,Production

Uses

Zasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM[1].

References

[1] Masse, Craig E, et al. Pyrazolopyrimidines as TYK2 inhibitors and their preparation: World Intellectual Property Organization, WO2019023468. 2019-01-31.
[2] SILVANA LEIT, CRAIG E. MASSE Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279[J]. Journal of Medicinal Chemistry, 2023, 66 15: 10473-10496. DOI: 10.1021/acs.jmedchem.3c00600

Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Suppliers

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2272904-53-5, Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-Related Search:

Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-

Zasocitinib

NDI-034858(Zasocitinib)

Zasocitinib，NDI-034858，TAK 279

N-((1R,2R)-2-methoxycyclobutyl)-7-(methylamino)-5-((2-oxo-2H-[1,2'-bipyridin]-3-yl)amino)pyrazolo[1,5-a]pyrimidine-3-carboxamide

N-[(1R,2R)-2-Methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo-2H-[1,2’-bipyridin]-3-yl)amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide

TAK 279

N-((1R,2R)-2-Methoxy-cyclobutyl)-7-(methylamino)-5-((2-oxo-2H-[1,2'-bipyridin]-3-yl)amino)-1H-pyrazolo[1,5-a]pyrimidine-3-carboxamide

2272904-53-5