ChemicalBook > CAS DataBase List > 2-Deoxy-D-ribonic-1,4-lactone

2-Deoxy-D-ribonic-1,4-lactone

Product Name
2-Deoxy-D-ribonic-1,4-lactone
CAS No.
34371-14-7
Chemical Name
2-Deoxy-D-ribonic-1,4-lactone
Synonyms
(4S,5R)-4-Hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one;2-Deoxy-D-ribono-1,4-lactone;2'-Deoxyribolactone;2'-Deoxyribonolactone;2-deoxy-D-ribonolactone;2-Deoxy-D-ribonic-1,4-lactone;2-Deoxy-D-ribonic acid γ-lactone;2-Deoxy-D-ribonic acid-1,4-lactone;2-Deoxy-D-ribono-1,4-lactone;2-Deoxy-D-ribono-1,4-lactone >=95% (GC)
CBNumber
CB31231464
Molecular Formula
C5H8O4
Formula Weight
132.11
MOL File
34371-14-7.mol
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2-Deoxy-D-ribonic-1,4-lactone Property

Boiling point:
395.3±27.0 °C(Predicted)
Density 
1.438±0.06 g/cm3(Predicted)
storage temp. 
-20°C
pka
12.63±0.40(Predicted)
Appearance
Light yellow to yellow Liquid
optical activity
[α]/D 19.0±2.5°, c = 1 in H2O
BRN 
81260
InChI
InChI=1/C5H8O4/c6-2-4-3(7)1-5(8)9-4/h3-4,6-7H,1-2H2/t3-,4+/s3
InChIKey
YIXDEYPPAGPYDP-IUYQGCFVSA-N
SMILES
C1(O[C@H](CO)[C@@H](O)C1)=O |&1:2,5,r|
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
H953178
Product name
(4S,5R)-4-Hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one
Packaging
500mg
Price
$220
Updated
2021/12/16
Usbiological
Product number
292956
Product name
2-Deoxy-D-ribonic acid-1,4-lactone
Packaging
250mg
Price
$360
Updated
2021/12/16
Biosynth Carbosynth
Product number
MD00127
Product name
2-Deoxy-D-ribonic acid-1,4-lactone
Packaging
5G
Price
$682.5
Updated
2021/12/16
AK Scientific
Product number
2070AL
Product name
2-Deoxy-D-ribonicacid-1,4-lactone
Packaging
10g
Price
$698
Updated
2021/12/16
Biosynth Carbosynth
Product number
MD00127
Product name
2-Deoxy-D-ribonic acid-1,4-lactone
Packaging
2g
Price
$315
Updated
2021/12/16
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2-Deoxy-D-ribonic-1,4-lactone Chemical Properties,Usage,Production

Definition

ChEBI: 2-deoxy-D-ribono-1,4-lactone is a ribonolactone. It has a role as a metabolite. It is functionally related to a D-ribonic acid.

Synthesis

533-67-5

34371-14-7

Example 1A Synthesis of (4S,5R)-4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one: 2-deoxy-D-ribose (10 g, 74.6 mmol) and water (60 mL) were added to a 500 mL round-bottomed flask, followed by slow dropwise addition of bromine (59.6 g, 373 mmol). The reaction mixture was stirred at room temperature for 5 days. After completion of the reaction, the mixture was diluted with water (300 mL) and extracted with tert-butyl methyl ether (3 x 200 mL). The aqueous layer was neutralized with silver carbonate to pH 6 and filtered to remove the resulting solid. The filtrate was concentrated under vacuum to give a residue. The residue was dissolved in ethyl acetate (200 mL) and dried by adding magnesium sulfate. After standing overnight, the solid was removed by filtration and the filtrate was concentrated to give (4S,5R)-4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one as an oil (7.72 g, 78%).1H NMR (400 MHz, CDCl3) δ 1.83 (t, J = 5.9 Hz, 1H), 2.13 (d, J = 4.3 Hz, 1H), 2.57 (dd, J = 4.3 Hz, 1H) 2.57 (dd, J = 18.1, 4.0 Hz, 1H), 3.00 (dd, J = 18.0, 7.2 Hz, 1H), 3.85 (m, 1H), 3.97 (m, 1H), 4.46 (q, J = 3.2 Hz, 1H), 4.65 (m, 1H).

References

[1] European Journal of Organic Chemistry, 2013, # 7, p. 1306 - 1317
[2] Patent: US2017/57981, 2017, A1. Location in patent: Paragraph 0268; 0269; 0320; 0321
[3] RSC Advances, 2014, vol. 4, # 22, p. 11023 - 11028
[4] Patent: WO2011/3018, 2011, A2. Location in patent: Page/Page column 40-41
[5] Patent: WO2015/81297, 2015, A1. Location in patent: Paragraph 00291

2-Deoxy-D-ribonic-1,4-lactone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Deoxy-D-ribonic-1,4-lactone Suppliers

China 74 Europe 1 India 1 Switzerland 1 United Kingdom 4 United States 6 Global 87
Beijing Qinling Mountains Pharmaceutical Co., Ltd.
Tel
010-61241352 18901327973
Email
834537306@qq.com
Country
China
ProdList
530
Advantage
58
Beijing Qinling Pharmaceutical Co., Ltd.
Tel
010-61241352 18901327973
Email
834537306@qq.com
Country
China
ProdList
5860
Advantage
58
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
Advantage
55
Nanjing Baifuli Technology Co., Ltd.
Tel
25-25-58740604 15951658055
Fax
+86-25-58356858
Email
sales@unisyn.cn
Country
China
ProdList
591
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
6295
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6468
Advantage
55
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7992
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
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View Lastest Price from 2-Deoxy-D-ribonic-1,4-lactone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Deoxy-D-ribonic-1,4-lactone 34371-14-7
Price
US $0.00/G
Min. Order
10G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-14
Career Henan Chemical Co
Product
2-Deoxy-D-ribonic-1,4-lactone 34371-14-7
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-25

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