7-Azabicyclo[2,2,1]heptane hydrochloride
- Product Name
- 7-Azabicyclo[2,2,1]heptane hydrochloride
- CAS No.
- 27514-07-4
- Chemical Name
- 7-Azabicyclo[2,2,1]heptane hydrochloride
- Synonyms
- 7-AZABICYCLO[2.2.1]HEPTANE HYDROCHLORIDE;SW-74;SWF-74;7-AZABICYCLO[2,2,1]HEPTANE HCL;7-Azabicyclo[2.2.1]heptane, hydrochloride (1:1);(1s,4s)-7-azabicyclo[2.2.1]heptane hydrochloride
- CBNumber
- CB3123148
- Molecular Formula
- C6H12ClN
- Formula Weight
- 133.62
- MOL File
- 27514-07-4.mol
7-Azabicyclo[2,2,1]heptane hydrochloride Property
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C6H11N.ClH/c1-2-6-4-3-5(1)7-6;/h5-7H,1-4H2;1H
- InChIKey
- JQHCKZLQJDVZPH-UHFFFAOYSA-N
- SMILES
- C12CCC(CC1)N2.Cl
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A965488
- Product name
- 7-Azabicyclo[2,2,1]heptaneHydrochloride
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FA144373
- Product name
- 7-Azabicyclo[2.2.1]heptane hydrochloride
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- J97862
- Product name
- 7-Azabicyclo[2,2,1]heptanehydrochloride
- Packaging
- 1g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- OR962480
- Product name
- 7-Azabicyclo[2.2.1]heptanehydrochloride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $182
- Updated
- 2021/12/16
- Product number
- FA144373
- Product name
- 7-Azabicyclo[2.2.1]heptane hydrochloride
- Packaging
- 500mg
- Price
- $230
- Updated
- 2021/12/16
7-Azabicyclo[2,2,1]heptane hydrochloride Chemical Properties,Usage,Production
Synthesis
188624-92-2
27514-07-4
The compound (CAS: 188624-92-2, 380 g, 1.51 mol) was dissolved in tetrahydrofuran (THF, 3 L) under nitrogen protection and cooled to 0°C. Lithium aluminum hydride (229.4 g, 6.04 mol) solid pellets were added in batches over a period of 2 hours. The reaction mixture was gradually warmed to room temperature with continuous stirring for 4 days until HPLC analysis showed complete consumption of the feedstock. Upon completion of the reaction, the reaction mixture was diluted with THF (11 L) and re-cooled to 0°C. Under rapid stirring, sodium sulfate decahydrate solid was added slowly over a period of 2 h until gas release ceased. The insoluble material was removed by filtration and the filtrate was acidified with gaseous hydrogen chloride to produce a white precipitate. The precipitate was collected by filtration, washed with THF (2 x 500 mL) and dried to constant weight to give 7-azabicyclo[2,2,1]heptane hydrochloride (M1, batch 1: 86.8 g, 43%; batch 2: 97.3 g, 49%). The filter cake from the first filtration was resuspended in 6 N sodium hydroxide solution (400 mL) and filtered. The filtrate was extracted with ether (4 L) and the organic layer was acidified with gaseous hydrogen chloride, again producing a white precipitate. The precipitate was collected by filtration, washed with ether (2 x 500 mL) and dried in a vacuum oven at 40 °C to constant weight to give finally 7-azabicyclo[2,2,1]heptane hydrochloride (M I.HCl, 105.9 g, 72%).
References
[1] Patent: WO2005/79805, 2005, A1. Location in patent: Page/Page column 61
[2] Tetrahedron, 2009, vol. 65, # 29-30, p. 5805 - 5816
[3] Patent: WO2005/80402, 2005, A1. Location in patent: Page/Page column 65
[4] Patent: WO2005/79805, 2005, A1. Location in patent: Page/Page column 61
[5] Organic Letters, 2001, vol. 3, # 9, p. 1371 - 1373
7-Azabicyclo[2,2,1]heptane hydrochloride Preparation Products And Raw materials
Raw materials
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View Lastest Price from 7-Azabicyclo[2,2,1]heptane hydrochloride manufacturers
- Product
- 7-Azabicyclo[2.2.1]heptane hydrochloride 27514-07-4
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-05
- Product
- 7-Azabicyclo[2,2,1]heptane hydrochloride 27514-07-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19