(Diethoxymethyl)diphenylphosphine oxide

Product Name
(Diethoxymethyl)diphenylphosphine oxide
CAS No.
20570-20-1
Chemical Name
(Diethoxymethyl)diphenylphosphine oxide
Synonyms
Oxide;Quinidine 1’Rifampicin N-4’2,3-Diethyl-5-methylpyrazine-N’(Diethoxymethyl)diphenylphosphine oxide;Phosphine oxide, (diethoxymethyl)diphenyl-
CBNumber
CB31236939
Molecular Formula
C17H21O3P
Formula Weight
304.32
MOL File
20570-20-1.mol
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(Diethoxymethyl)diphenylphosphine oxide Property

Melting point:
73-75 °C
Boiling point:
381.2±32.0 °C(Predicted)
Density 
1.12±0.1 g/cm3(Predicted)
solubility 
sol benzene, THF, and ether.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FD52912
Product name
(Diethoxymethyl)Diphenylphosphine Oxide
Packaging
25mg
Price
$96.25
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD52912
Product name
(Diethoxymethyl)Diphenylphosphine Oxide
Packaging
50mg
Price
$148
Updated
2021/12/16
AK Scientific
Product number
4331AH
Product name
(Diethoxymethyl)diphenylphosphineoxide
Packaging
100mg
Price
$212
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD52912
Product name
(Diethoxymethyl)Diphenylphosphine Oxide
Packaging
100mg
Price
$228
Updated
2021/12/16
AK Scientific
Product number
4331AH
Product name
(Diethoxymethyl)diphenylphosphineoxide
Packaging
250mg
Price
$374
Updated
2021/12/16
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(Diethoxymethyl)diphenylphosphine oxide Chemical Properties,Usage,Production

Uses

(Diethoxymethyl)diphenylphosphine Oxide is a readily accessible Horner-Wittig reagent for the conversion of aldehydes and ketones into homologous O,O-ketene acetals.[1]

Preparation

(Diethoxymethyl)diphenylphosphine Oxide (1) can be conveniently prepared by reaction of Chlorodiphenylphosphine with Triethyl Orthoformate. [2] Adduct (2) is formed in a fast, exothermic, step. Upon heating, an Arbuzov reaction occurs to give the phosphine oxide (eq 1). Other O,O-acetals of formyldiphenylphosphine oxide can be prepared equally well. The usual procedure is for chlorodiphenylphosphine (88.2 g, 0.4 mol) to be added dropwise to triethyl orthoformate (59.3 g, 0.4 mol) over a period of 45 min. Subsequent heating of the reaction mixture (2 h, 110 °C) leads to formation of 24 g (93% of theory) of ethyl chloride. Upon cooling, a practically quantitative yield of (1) is obtained, mp 74-77 °C. Addition of some solvent, when (1) starts precipitating, avoids the formation of a solid cake that is hard to remove from the reaction flask. Crystallization from benzene/petroleum ether (80-110) affords the pure phosphine oxide.
(Diethoxymethyl)diphenylphosphine oxide synthesis

storage

(Diethoxymethyl)diphenylphosphine Oxide is infinitely stable at rt. It should be protected from moisture.

References

1. van Schaik, T. A. M.; Henzen, A. V.; van der Gen, A. TL 1983, 24, 1303.
2. Dietsche, W. LA 1968, 712, 21.

(Diethoxymethyl)diphenylphosphine oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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(Diethoxymethyl)diphenylphosphine oxide Suppliers

Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001 13552411790
Fax
021-33690831
Email
postmaster@tyjchem.cn
Country
China
ProdList
1541
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55
Aikon International Limited
Tel
025-58851090 13611564524
Fax
(6)02557626880
Email
lwan@aikonchem.com
Country
China
ProdList
15951
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Shandong Mingde Biotechnology Co., Ltd
Tel
18560864701
Email
1054234218@qq.com
Country
China
ProdList
4500
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58

20570-20-1, (Diethoxymethyl)diphenylphosphine oxideRelated Search:


  • (Diethoxymethyl)diphenylphosphine oxide
  • Oxide
  • Quinidine 1&rsquo
  • Rifampicin N-4&rsquo
  • 2,3-Diethyl-5-methylpyrazine-N&rsquo
  • Phosphine oxide, (diethoxymethyl)diphenyl-
  • 20570-20-1