HPPH (Photochlor)
- Product Name
- HPPH (Photochlor)
- CAS No.
- 149402-51-7
- Chemical Name
- HPPH (Photochlor)
- Synonyms
- Photochlor;Sulcardine;Photochlor (HTTP);Photochlor (HPPH);HPPH, 10 mM in DMSO;Photochlor Photochlor;Inhibitor,HPPH,inhibit;3-Devinyl-3-(1'-hexyloxy)ethylpyropheophorbide A;2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a;14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-4-phorbine propanoic acid
- CBNumber
- CB31238726
- Molecular Formula
- C39H48N4O4
- Formula Weight
- 636.82
- MOL File
- 149402-51-7.mol
HPPH (Photochlor) Property
- Boiling point:
- 992.5±65.0 °C(Predicted)
- Density
- 1.184
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO:3.0(Max Conc. mg/mL);4.7(Max Conc. mM)
- form
- A crystalline solid
- color
- Light brown to black
- InChIKey
- RBLODCJRUDEMCI-ALMPYOEESA-N
- SMILES
- C12CC(=O)C3C=1NC(C=3C)C=C1NC(C(C)=C1CC)=CC1NC(=C(C)C=1C(OCCCCCC)C)C=C1N=C2[C@@H](CCC(O)=O)[C@@H]1C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child
H370Causes damage to organs
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20611
- Product name
- HPPH
- Purity
- ≥98% (mixture of epimers)
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 20611
- Product name
- HPPH
- Purity
- ≥98% (mixture of epimers)
- Packaging
- 5mg
- Price
- $190
- Updated
- 2024/03/01
- Product number
- 20611
- Product name
- HPPH
- Purity
- ≥98% (mixture of epimers)
- Packaging
- 10mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- 20611
- Product name
- HPPH
- Purity
- ≥98% (mixture of epimers)
- Packaging
- 25mg
- Price
- $770
- Updated
- 2024/03/01
- Product number
- P365010
- Product name
- Photochlor
- Packaging
- 5mg
- Price
- $175
- Updated
- 2021/12/16
HPPH (Photochlor) Chemical Properties,Usage,Production
Description
Photochlor, also known as HTTP, is a lipophilic, second-generation, chlorin-based photosensitizer. HPPH is a chlorin that acts as a photosensitizer in photodynamic therapy (PDT) when stimulated with light at 655 nm. When administered systemically, HPPH accumulates in tumor cells and, when stimulated with light in the presence of oxygen, reactive oxygen species (ROS) are generated, leading to necrosis within the tumor. HPPH, at a dose of 0.5 mg/kg, increases survival in a nude rat model of glioma. It works synergistically with gemcitabine in several pancreatic cancer cell lines to induce cell death.
Uses
Photochlor is an anticancer photodynamic therapy drug that triggers multiple drug release and tumor killing cells in mouse breast cancer xenograft. Also functions as a photochlor-mediated photodynamic therapy for non-small cellular lung cancer treatment in murine model.
in vivo
Tumors are treated with an immune-enhancing PDT regimen followed by a tumor-controlling PDT regimen can leads to enhancement of anti-tumor immunity, while retaining effective control of primary tumor growth. To test this hypothesis, a combination treatment regimen is devised in which Colo26-HA tumor-bearing BALB/c mice are treated with a HPPH-PDT regimen known to lead to enhanced anti-tumor immunity (0.4 μmoles/kg HPPH followed 18 h later by illumination with 665 nm light for a total dose of 48 J/cm2). Following illumination, mice are rested for 9 days; on the ninth day, mice are injected with HPPH. On day 10 following the first treatment, tumors are treated with a tumor control treatment regimen (illumination with 665 nm light for a total dose of 132 J/cm2 given)[2].
References
[1] DENNIS E.J.G.J. DOLMANS Rakesh K J Dai Fukumura. Photodynamic therapy for cancer[J]. Nature Reviews Cancer, 2003, 3 5: 380-387. DOI: 10.1038/nrc1071
[2] JEFFREY LOBEL MD. 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) in a nude rat glioma model: Implications for photodynamic therapy[J]. Lasers in Surgery and Medicine, 2001, 29 5: 397-405. DOI: 10.1002/lsm.10001
[3] MD G S, PHD Emmanuel C G M Marlys A Anderson BS, MPH, et al. Synergistic effects of photodynamic therapy with HPPH and gemcitabine in pancreatic cancer cell lines?[J]. Lasers in Surgery and Medicine, 2012, 44 9: 755-761. DOI: 10.1002/lsm.22073
HPPH (Photochlor) Preparation Products And Raw materials
Raw materials
Preparation Products
HPPH (Photochlor) Suppliers
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View Lastest Price from HPPH (Photochlor) manufacturers
- Product
- Photochlor Photochlor 149402-51-7
- Price
- US $10.00/g/Bag
- Min. Order
- 10g
- Purity
- 99
- Supply Ability
- 100KG
- Release date
- 2021-11-16
- Product
- 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid 149402-51-7
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02