Testosterone undecanoate
- Product Name
- Testosterone undecanoate
- CAS No.
- 5949-44-0
- Chemical Name
- Testosterone undecanoate
- Synonyms
- andriol;Undecanoate;Testosterone 17-undecanoate;Testo U;Test Unde;Test undeca;BoldenoneUndecanoate;Testosterone Undecan;TESTOSTERONE UNDECANOATE;Testosaterone undecanoate
- CBNumber
- CB3123991
- Molecular Formula
- C30H48O3
- Formula Weight
- 456.71
- MOL File
- 5949-44-0.mol
Testosterone undecanoate Property
- Melting point:
- 59-61°C
- Boiling point:
- 550.7±50.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- Controlled Substance, -20°C Freezer
- solubility
- DMSO : 10 mg/mL (21.90 mM; Need ultrasonic and warming)
- form
- Solid
- color
- White to Off-White
- InChIKey
- UDSFVOAUHKGBEK-JCROKFDDNA-N
- SMILES
- C[C@]12CCC(=O)C=C1CC[C@@]1([H])[C@]3([H])CC[C@H](OC(=O)CCCCCCCCCC)[C@@]3(C)CC[C@]21[H] |&1:1,10,12,16,30,34,r|
- CAS DataBase Reference
- 5949-44-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H362May cause harm to breast-fed children
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- MT-59041
- Product name
- Testosteroneundecanoate
- Purity
- 98%
- Packaging
- 5g
- Price
- $810
- Updated
- 2021/12/16
- Product number
- T-6913
- Product name
- TestosteroneUndecanoate
- Packaging
- 25mg
- Price
- $1200
- Updated
- 2021/12/16
Testosterone undecanoate Chemical Properties,Usage,Production
Description
Testosterone undecanoate, sold under the brand names Andriol and Aveed among others, is an androgen and anabolic steroid (AAS) medication that is used mainly in the treatment of low testosterone levels in men. which includes hormone therapy for transgender men. It is taken by mouth or given by injection into muscle.
Testosterone Undecanoate is the undecanoate ester form of the androgen testosterone, with gonadotropin-secretory inhibiting and hormone replacement activity. As testosterone inhibits the secretion of gonadotropins from the pituitary gland, administration of testosterone decreases the secretion of luteinizing hormone (LH). By inhibiting LH secretion, the growth of Leydig cells, which are normally stimulated by LH to produce testosterone, may be suppressed. In addition, this agent promotes the maintenance of male sex characteristics and can be used for testosterone replacement in hypogonadal males.
Chemical Properties
White Solid
Uses
Testosterone undecanoate is the ester prodrug of testosterone and has a midchain fatty acid at the 17Beta position. It is available as an intramuscular injection and as an oral capsule, and is indicated for treatment of testosterone deficiency. It should be noted that testosterone undecanoate is only indicated for treatment of hypogonadal conditions with structural or genetic etiologies and should not be used to manage "age-related hypogonadism".
Indications
JATENZO (testosterone undecanoate) is an androgen indicated for testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone:
Primary hypogonadism (congenital or acquired): testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchiectomy, Klinefelter syndrome, chemotherapy, or toxic damage from alcohol or heavy metals. These men usually have low serum testosterone concentrations and gonadotropins (follicle-stimulating hormone [FSH], luteinizing hormone [LH]) above the normal range.
Hypogonadotropic hypogonadism (congenital or acquired): gonadotropin or luteinizing hormone-releasing hormone (LHRH) deficiency or pituitary-hypothalamic injury from tumors, trauma, or radiation. These men have low testosterone serum concentrations but have gonadotropins in the normal or low range.
www.accessdata.fda.gov
Definition
ChEBI: Testosterone undecanoate is a steroid ester. It is a metabolite of Testosterone. It is a promising androgen for male hormonal contraception.
Pharmacokinetics
Testosterone undecanoate is a prodrug of testos-terone esterified in the 17b-position with undecanoic acid. Following oral administration, thisprodrug is metabolized only partly in the intestinal wall, and the remaining fraction of testosterone undecanoate is absorbed via the lymphatic system, and hence, avoids first pass hepatic metabolism. After reaching the systemic circulation, testosterone undecanoate rapidly converts to free testosterone. The absolute bioavailability of testosterone following oral administration of testosterone undecanoate is estimated to be 7%. Recent studies in lymph duct cannulated dogs revealed that all of the testosterone undecanoate absorbed into the systemic circulation is due to lymphatic absorption of the prodrug, and more than 80% of the free testosterone in the plasma is contributed by systemic hydrolysis of the lymphatically transported prodrug.
Side effects
Side effects of testosterone undecanoate include symptoms of masculinization like acne, increased hair growth, voice changes, hypertension, elevated liver enzymes, hypertriglyceridemia, and increased sexual desire. The drug is a prodrug of testosterone, the biological ligand of the androgen receptor (AR) and hence is an androgen and anabolic steroid. It has strong androgenic effects and moderate anabolic effects, which make it useful for producing masculinization and suitable for androgen replacement therapy. Testosterone undecanoate is a testosterone ester and a prodrug of testosterone in the body. Because of this, it is considered to be a natural and bioidentical form of testosterone.
Testosterone undecanoate Preparation Products And Raw materials
Raw materials
Preparation Products
Testosterone undecanoate Suppliers
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View Lastest Price from Testosterone undecanoate manufacturers
- Product
- Testosterone undecanoate 5949-44-0
- Price
- US $65.00-50.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 20tons
- Release date
- 2024-05-11
- Product
- Testosterone undecanoate 5949-44-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 500KG
- Release date
- 2018-09-14
- Product
- Testosterone undecanoate 5949-44-0
- Price
- US $600.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 2 tons
- Release date
- 2023-04-03