ChemicalBook > CAS DataBase List > AMD 3465 (*Hexahydrobromide*)

AMD 3465 (Hexahydrobromide)

Product Name: AMD 3465 (*Hexahydrobromide*)
CAS No.: 185991-07-5
Chemical Name: AMD 3465 (*Hexahydrobromide*)
Synonyms: CS-810;AMD 3465;AMD3465,98%;GENZ-644494;AMD 3465 (hydrobroMide);AMD3465;AMD-3465;AMD 3465;AMD 3465 (*Hexahydrobromide*);AMD3465 R10406hexahydrobromide;AMD 3465 hexahydrobromide, 10 mM in DMSO;AMD 3465 hexahydrobromide, CXCR4 antagonist
CBNumber: CB31244963
Molecular Formula: C24H39BrN6
Formula Weight: 491.52
MOL File: 185991-07-5.mol

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AMD 3465 (Hexahydrobromide) Property

Melting point:: >200°C (dec.)
storage temp.: -20°C
solubility: DMSO (Slightly), Methanol (Very Slightly), Water (Slightly)
form: powder
color: white to light brown
Water Solubility: H2O: 25mg/mL, clear

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1433
Product name: AMD3465
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $146
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1433
Product name: AMD3465
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $577
Updated: 2025/07/31

Cayman Chemical

Product number: 11959
Product name: AMD 3465 (hydrobromide)
Purity: ≥95%
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 11959
Product name: AMD 3465 (hydrobromide)
Purity: ≥95%
Packaging: 10mg
Price: $182
Updated: 2024/03/01

Cayman Chemical

Product number: 11959
Product name: AMD 3465 (hydrobromide)
Purity: ≥95%
Packaging: 25mg
Price: $403
Updated: 2024/03/01

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AMD 3465 (Hexahydrobromide) Chemical Properties,Usage,Production

Uses

AMD 3465 is a CXCR4 antagonist and in combination with monoclonal antibody, was shown to be potentially effective in reducing tumor growth and increasing survival in patient with B cell lymphoma

Biochem/physiol Actions

AMD3465 is also termed as{N-[1,4,8,11-tetraazacyclotetradecanyl-1,4-phenylenebis(methylene)]-2-(aminomethyl)pyridine}. It controls oncogenic signaling and invasiveness in vitro. It inhibits breast cancer growth and metastasis in vivo. As a chemokine receptor 4 (CXCR4) antagonist, AMD3465 is ten times more efficient than bicyclam AMD3100.

in vivo

AMD 3465 (2.5 mg/kg/d, s.c. for 5 weeks) significantly blocks the growth of U87 GBM and Daoy xenografts^[2].

IC 50

12G5 mAb-CXCR4: 0.75 nM (IC₅₀, in SupT1 cells); CXCL12^AF647-CXCR4: 18 nM (IC₅₀, in SupT1 cells); X4 HIV-1 (NL4.3): 6.1 nM (IC₅₀, in MT-4 cells); X4 HIV-1 (RF): 7.4 nM (IC₅₀, in MT-4 cells); X4 HIV-1 (HE): 9.8 nM (IC₅₀, in MT-4 cells); X4 HIV-1 (III_B): 12.3 nM (IC₅₀, in MT-4 cells); X4 HIV-1 (NL4.3^AMD3100): 2822 nM (IC₅₀, in MT-4 cells); HIV-2 (ROD): 12.3 nM (IC₅₀, in MT-4 cells); HIV-2 (EHO): 12.3 nM (IC₅₀, in MT-4 cells)

storage

Store at -20°C

AMD 3465 (Hexahydrobromide) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AMD 3465 (Hexahydrobromide) manufacturers

Honest Joy Holdings Limited

Product: AMD3465hexahydrobroMide 185991-07-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.4%
Supply Ability: 100 tons
Release date: 2022-01-14

Career Henan Chemical Co

Product: AMD 3465 (*Hexahydrobromide*) 185991-07-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2020-01-13

185991-07-5, AMD 3465 (Hexahydrobromide)Related Search:

AMD 3465 (*Hexahydrobromide*)

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185991-07-5

C24H38N66HBr

C24H44Br6N6

AMD 3465 (*Hexahydrobromide*)

AMD 3465 (*Hexahydrobromide*) Property

Hazard and Precautionary Statements (GHS)

N-Bromosuccinimide Price

AMD 3465 (*Hexahydrobromide*) Chemical Properties,Usage,Production

Uses

Biochem/physiol Actions

in vivo

IC 50

storage

AMD 3465 (*Hexahydrobromide*) Preparation Products And Raw materials

Raw materials

Preparation Products

AMD 3465 (*Hexahydrobromide*) Suppliers

View Lastest Price from AMD 3465 (*Hexahydrobromide*) manufacturers

185991-07-5, AMD 3465 (*Hexahydrobromide*)Related Search:

AMD 3465 (Hexahydrobromide)

AMD 3465 (Hexahydrobromide) Property

AMD 3465 (Hexahydrobromide) Chemical Properties,Usage,Production

AMD 3465 (Hexahydrobromide) Preparation Products And Raw materials

AMD 3465 (Hexahydrobromide) Suppliers

View Lastest Price from AMD 3465 (Hexahydrobromide) manufacturers

185991-07-5, AMD 3465 (Hexahydrobromide)Related Search: