ChemicalBook > CAS DataBase List > (2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide

(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide

Product Name
(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide
CAS No.
133865-88-0
Chemical Name
(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide
Synonyms
ralfinamide;Priralfinamide;Nw-1029;FCE-26742A;Ralfinamida;Safinamide-6;Unii-3lpf0S0gvv;Ralfinamide [inn];Guadecitabine Sodium;2- Fluoro Safinamide
CBNumber
CB31260820
Molecular Formula
C17H19FN2O2
Formula Weight
302.34
MOL File
133865-88-0.mol
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(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide Property

Boiling point:
479.0±40.0 °C(Predicted)
Density 
1.189
storage temp. 
2-8°C(protect from light)
solubility 
DMSO: ≥ 125 mg/mL (413.44 mM)
pka
16.03±0.50(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0021330
Product name
Ralfinamide
Purity
99.78%
Packaging
10mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0021330
Product name
Ralfinamide
Purity
99.78%
Packaging
50mg
Price
$360
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008093
Product name
RALFINAMIDE
Purity
95.00%
Packaging
5MG
Price
$497.39
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008093
Product name
RALFINAMIDE
Purity
95.00%
Packaging
1G
Price
$945
Updated
2021/12/16
AK Scientific
Product number
6134AA
Product name
(S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)amino)propanamide
Packaging
5g
Price
$1242
Updated
2021/12/16
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(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide Chemical Properties,Usage,Production

Uses

Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain[1][2].

Biological Activity

Ralfinamide (FCE-26742A) is an orally available sodium channel blocker derived from α-aminoamide with analgesic properties.

in vivo

Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain[1].

Animal Model:81 adult male Sprague–Dawley male rats (260–460 g)[1]
Dosage:80 mg/kg (7 days preoperatively), 30 mg/kg, 60 mg/kg (postoperative)
Administration:Oral gavage; twice daily; until postoperative day 42
Result:Suppressed neuropathic pain.

References

[1] Zhang SH, et al. Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain. 2008 Oct 15;139(2):293-305. DOI:10.1016/j.pain.2008.04.020
[2] Liang X, et al. Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. Eur J Pharmacol. 2018 Mar 15;823:27-34. DOI:10.1016/j.ejphar.2018.01.041

(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide Suppliers

China 82 India 3 United States 9 Global 94
Adamas Reagent, Ltd.
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AN PharmaTech Co Ltd
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Amadis Chemical Company Limited
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571-89925085
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MQ (shanghai) Pharmaceuticals Co., Ltd.
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View Lastest Price from (2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide manufacturers

Career Henan Chemical Co
Product
(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide 133865-88-0
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-02

133865-88-0, (2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamideRelated Search:

Safinamide Impurity 11 Safinamide Impurity 8 Safinamide Impurity 1 Safinamide (S)-2-((3-((3-fluorobenzyl)oxy)benzyl)amino)propanamide 3-(3-fluorobenzyl)-4-(3-fluoro-benzyloxy)benzaldehyde FCE 28073 Safinamide Impurity 9 Safinamide Impurity 5 (S)-2-((4-((4-fluorobenzyl)oxy)benzyl)amino)propanamide (S)-2-((4-(benzyloxy)benzyl)amino)propanamide Safinamide Impurity 7 Safinamide Impurity 3 Safinamide Impurity 4 Safinamide Impurity 2 Safinamide Impurity 6 Safinamide Impurity 5 Propionamide

  • (2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide
  • ralfinamide
  • (S)-2-[[4-[(2-Fluorobenzyl)oxy]benzyl]amino]propanamide
  • (2S)-2-(4-(2-Fluorobenzyloxy)benzylamino)propanamide
  • Safinamide impurity 3/(S)-2-((4-((2-fluorobenzyl)oxy)benzyl)amino)propanamide
  • (2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide/Safinamide Impurity
  • Safinamide-6
  • Guadecitabine Sodium
  • FCE-26742A
  • Safinamide Impurity 12
  • Nw-1029
  • Ralfinamida
  • Ralfinamida [inn-spanish]
  • Ralfinamide [inn]
  • Unii-3lpf0S0gvv
  • Priralfinamide
  • Propanamide, 2-[[[4-[(2-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2S)-
  • 2- Fluoro Safinamide
  • Inhibitor,Na channels,inhibit,Na+ channels,Sodium Channel,Ralfinamide
  • Safinamide Impurity O
  • Ralfinamide, 10 mM in DMSO
  • 133865-88-0
  • C17H19FN2O2
  • Inhibitor