4-Hydroxy-1-(4-nitrophenyl)piperidine

Product Name: 4-Hydroxy-1-(4-nitrophenyl)piperidine
CAS No.: 79421-45-7
Chemical Name: 4-Hydroxy-1-(4-nitrophenyl)piperidine
Synonyms: 1-(4-Nitrophenyl)piperidin-4-ol;4-Piperidinol, 1-(4-nitrophenyl)-;4-Hydroxy-1-(4-nitrophenyl)piperidine;4-amino-3-(3,4,8-trimethoxyphenyl)butanoicacid;1-(4-Nitrophenyl)piperidin-4-ol, 4-(4-Hydroxypiperidin-1-yl)nitrobenzene
CBNumber: CB31262990
Molecular Formula: C11H14N2O3
Formula Weight: 222.24
MOL File: 79421-45-7.mol

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4-Hydroxy-1-(4-nitrophenyl)piperidine Property

Melting point:: 114-116 °C(Solv: isopropanol (67-63-0))
Boiling point:: 421.5±40.0 °C(Predicted)
Density: 1.303±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.69±0.20(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: N900643
Product name: 1-(4-Nitrophenyl)-4-piperidinol
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 044764
Product name: 1-(4-Nitrophenyl)-4-piperidinol
Purity: >95%
Packaging: 1g
Price: $47
Updated: 2021/12/16

AK Scientific

Product number: 9838AE
Product name: 1-(4-Nitrophenyl)-4-piperidinol
Packaging: 1g
Price: $104
Updated: 2021/12/16

Matrix Scientific

Product number: 044764
Product name: 1-(4-Nitrophenyl)-4-piperidinol
Purity: >95%
Packaging: 5g
Price: $120
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H54-1-Z0
Product name: 4-Hydroxy-1-(4-nitrophenyl)piperidine
Packaging: 1g
Price: $120
Updated: 2021/12/16

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4-Hydroxy-1-(4-nitrophenyl)piperidine Chemical Properties,Usage,Production

Synthesis

5382-16-1

350-46-9

79421-45-7

General procedure for the synthesis of 1-(4-nitrophenyl)piperidin-4-ol from 4-hydroxypiperidine and p-fluoronitrobenzene: 4-hydroxypiperidine (2.12 g, 15.0 mmol) and p-fluoronitrobenzene (1.82 g, 18.0 mmol) were dissolved in N,N-dimethylformamide (DMF, 15 ml) and potassium carbonate (2.52 g, 18.0 mmol) was added . The reaction mixture was stirred at 85°C for 1 hour. After completion of the reaction, the solvent was removed by distillation under reduced pressure. Water was added to the residue which was then extracted with chloroform. The organic phase was dried with anhydrous magnesium sulfate and the solvent was again removed by reduced pressure distillation. The crude product obtained was purified by silica gel column chromatography (eluent: chloroform-acetonitrile) to give 1-(4-nitrophenyl)piperidin-4-ol (3.10 g, 93% yield). The melting point of the product was 115.6-117 °C. 1H-NMR (CDCl3/TMS) δppm: 1.62-1.74 (m, 2H), 1.99-2.02 (m, 2H), 2.87-2.95 (m, 2H), 3.47-3.54 (m, 2H), 3.82-3.88 (m, 1H), 6.85 (d, J=8.7 Hz, 2H), 7.19 (d, J=8.7Hz, 2H).

References

[1] Patent: EP1988077, 2008, A1. Location in patent: Page/Page column 64
[2] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 112
[3] Patent: CN106905245, 2017, A. Location in patent: Paragraph 0277; 0278; 0279; 0280
[4] Synthesis, 1981, # 8, p. 606 - 608
[5] Patent: EP1775298, 2007, A1. Location in patent: Page/Page column 38-39

4-Hydroxy-1-(4-nitrophenyl)piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxy-1-(4-nitrophenyl)piperidine Suppliers

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79421-45-7, 4-Hydroxy-1-(4-nitrophenyl)piperidineRelated Search:

4-Hydroxy-1-(4-nitrophenyl)piperidine 8-(2-FLUORO-4-NITROPHENYL)-1,4-DIOXA-8-AZASPIRO[4.5]DECANE 1-[5-(4-HYDROXYPIPERIDINO)-2-NITROPHENYL]-1-ETHANONE (4-METHOXYPHENYL)[8-(4-NITROPHENYL)-1-OXA-4,8-DIAZASPIRO[4.5]DEC-4-YL]METHANONE 1-(4-NITROPHENYL)-4-PIPERIDINYL BENZENECARBOXYLATE 1-(4-NITROPHENYL)-4-PIPERIDINYL 4-CHLOROBENZENECARBOXYLATE [4,5-BIS-(HYDROXYMETHYL)-4,5-DIHYDROISOXAZOLE-3-CARBOXYLIC ACID HYDRAZIDE][1-(4-NITROPHENYL)PIPERID-4-ONE]ACETAL 3-ETHOXYCARBONYL-4,5-BIS(HYDROXYMETHYL)-4,5-DIHYDROISOXAZOLE-[1-(4-NITROPHENYL)PIPERID-4-ONE]KETAL 3-ACETYL-4,5-BIS(HYDROXYMETHYL)-4,5-DIHYDROISOXAZOLE-N-(4-NITOPHENYL)PIPERID-4-ONE ACETAL N-(4-METHYLPHENYL)-8-(4-NITROPHENYL)-3-PHENYL-1-OXA-4,8-DIAZASPIRO[4.5]DECANE-4-CARBOXAMIDE IFLAB-BB F2108-0032 1-[5-(1,4-DIOXA-8-AZASPIRO[4.5]DEC-8-YL)-2-NITROPHENYL]-1-ETHANONE 3-(4-NITROPHENYL)-7,12-DIOXA-3-AZASPIRO[5.6]DODEC-9-ENE 1-(4-NITROPHENYL)-4-PIPERIDINYL 4-METHYLBENZENECARBOXYLATE 4-(4-METHOXYBENZYL)-8-(4-NITROPHENYL)-1-OXA-4,8-DIAZASPIRO[4.5]DECANE [N'-[(4-CHLOROPHENYL)METHYLIDENE]-4,5-BIS(HYDROXYMETHYL)-4,5-DIHYDRO-3-ISOXAZOLE CARBOHYDRAZIDE][1-(4-NITROPHENYL)PIPERID-4-ONE]ACETAL 1-(4-NITROPHENYL)-4-PIPERIDINYL 4-METHOXYBENZENECARBOXYLATE 1-(2-FLUORO-4-NITROPHENYL)PIPERIDIN-4-OL

4-Hydroxy-1-(4-nitrophenyl)piperidine

1-(4-Nitrophenyl)piperidin-4-ol

1-(4-Nitrophenyl)piperidin-4-ol, 4-(4-Hydroxypiperidin-1-yl)nitrobenzene

4-Piperidinol, 1-(4-nitrophenyl)-

4-amino-3-(3,4,8-trimethoxyphenyl)butanoicacid

79421-45-7