ChemicalBook > CAS DataBase List > 5-CYANO-2-FLUOROBENZOIC ACID

5-CYANO-2-FLUOROBENZOIC ACID

Application

Product Name: 5-CYANO-2-FLUOROBENZOIC ACID
CAS No.: 146328-87-2
Chemical Name: 5-CYANO-2-FLUOROBENZOIC ACID
Synonyms: 3-Carboxy-4-fluorobenzonitrile;Benzoic acid,5-cyano-2-fluoro-;5-CYANO-2-FLUOROBENZOIC ACID 5-
CBNumber: CB31264116
Molecular Formula: C8H4FNO2
Formula Weight: 165.12
MOL File: 146328-87-2.mol

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5-CYANO-2-FLUOROBENZOIC ACID Property

Melting point:: 187-189°
Boiling point:: 322.1±27.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
Flash point:: >110°
storage temp.: Sealed in dry,Room Temperature
pka: 2.71±0.10(Predicted)
form: wooly crystalline powder
color: White

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Safety

RIDADR: UN3439
HazardClass: 6.1
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B419958
Product name: 5-Cyano-2-fluorobenzoicAcid
Packaging: 1g
Price: $45
Updated: 2021/12/16

TRC

Product number: B419958
Product name: 5-Cyano-2-fluorobenzoicAcid
Packaging: 5g
Price: $155
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4637-3-07
Product name: 5-Cyano-2-fluorobenzoic acid
Purity: 98%
Packaging: 1g
Price: $15
Updated: 2021/12/16

Apolloscientific

Product number: PC5926
Product name: 5-Cyano-2-fluorobenzoicacid
Packaging: 5g
Price: $30
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4637-3-07
Product name: 5-Cyano-2-fluorobenzoic acid
Purity: 98%
Packaging: 5G
Price: $35
Updated: 2021/12/16

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5-CYANO-2-FLUOROBENZOIC ACID Chemical Properties,Usage,Production

Application

5-Cyano-2-fluorobenzoic acid, as a benzoic acid compound with multiple reaction sites and rich chemical reactivity, has broad chemical application prospects in fields such as basic chemical research in organic synthesis and drug development.

Chemical Properties

5-Cyano-2-fluorobenzoic acid contains several reaction sites in its structure and shows good chemical reaction activity, and it can undergo chlorination reaction under the action of dichlorosulfoxide. It can also undergo a condensation reaction with organic amines under the action of a condensation agent, and can be used in the preparation of the corresponding amide derivatives.

Synthesis

337362-21-7

146328-87-2

The general procedure for the synthesis of 2-fluoro-5-cyanobenzoic acid from methyl 5-cyano-2-fluorobenzoate was as follows: to a solution of ethanol (50 mL) containing methyl 5-cyano-2-fluorobenzoate (3.0 g, 16.8 mmol) was added a 40% aqueous solution of KOH (15 mL). The reaction mixture was heated to 45 °C and stirred continuously for 2 h until all solids were completely dissolved. Upon completion of the reaction, the mixture was cooled to room temperature and partially concentrated under reduced pressure. Subsequently, the reaction mixture was diluted with ethyl acetate (EtOAc) and acidified with 10% aqueous hydrochloric acid. The organic and aqueous layers were separated and the aqueous layer was further extracted with ethyl acetate (3 x 20 mL). All organic extracts were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product 2-fluoro-5-cyanobenzoic acid (3.0 g, 16.4 mmol, 98% yield). Mass spectrometry analysis (DCI/NH3) showed m/z 183 (M+NH4)+.

References

[1] Patent: US2010/69348, 2010, A1. Location in patent: Page/Page column 60
[2] Patent: US2010/63022, 2010, A1. Location in patent: Page/Page column 35
[3] Patent: US2011/294780, 2011, A1. Location in patent: Page/Page column 140

5-CYANO-2-FLUOROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CYANO-2-FLUOROBENZOIC ACID Suppliers

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View Lastest Price from 5-CYANO-2-FLUOROBENZOIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Cyano-2-fluorobenzoic acid 146328-87-2
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-07

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-CYANO-2-FLUOROBENZOIC ACID 146328-87-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-CYANO-2-FLUOROBENZOIC ACID 146328-87-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

146328-87-2, 5-CYANO-2-FLUOROBENZOIC ACIDRelated Search:

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146328-87-2