7-Benzothiazolecarboxylicacid(9CI)
- Product Name
- 7-Benzothiazolecarboxylicacid(9CI)
- CAS No.
- 677304-83-5
- Chemical Name
- 7-Benzothiazolecarboxylicacid(9CI)
- Synonyms
- 7-Benzothiazolecarboxylic acid;Benzothiazole-7-carboxylic acid;7-Benzothiazolecarboxylicacid(9CI);1,3-Benzothiazole-7-carboxylic acid
- CBNumber
- CB31275040
- Molecular Formula
- C8H5NO2S
- Formula Weight
- 179.2
- MOL File
- 677304-83-5.mol
7-Benzothiazolecarboxylicacid(9CI) Property
- Melting point:
- >300°C
- Density
- 1.508
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Aqueous Base (Slightly), DMSO (Slightly), Methanol (Very Slightly)
- form
- Solid
- color
- White
Safety
- HS Code
- 2934208090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B200050
- Product name
- 7-BenzothiazolecarboxylicAcid
- Packaging
- 500mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- FB141922
- Product name
- Benzo[d]thiazole-7-carboxylic acid
- Packaging
- 500mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- FB141922
- Product name
- Benzo[d]thiazole-7-carboxylic acid
- Packaging
- 100mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- W7813
- Product name
- Benzo[d]thiazole-7-carboxylicacid
- Packaging
- 250mg
- Price
- $141
- Updated
- 2021/12/16
- Product number
- FB141922
- Product name
- Benzo[d]thiazole-7-carboxylic acid
- Packaging
- 250mg
- Price
- $167.5
- Updated
- 2021/12/16
7-Benzothiazolecarboxylicacid(9CI) Chemical Properties,Usage,Production
Uses
7-Benzothiazolecarboxylic Acid is an intermediate used in the synthesis of pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1). It is also used to prepare aminofuro-pyridine derivatives as inhibitors of TAK1.
Synthesis
677304-90-4
677304-83-5
The general procedure for the synthesis of 7-carboxybenzothiazole from ethyl benzo[d]thiazole-7-carboxylate was as follows: an aqueous sodium hydroxide solution (50%, 10 mL) was slowly added to a mixture of methanol (65 mL) and tetrahydrofuran (20 mL) containing ethyl 1,3-benzothiazole-7-carboxylate (3.5 g, 16.89 mmol) at 0 °C, followed by water ( 5 mL). The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the volatile solvent was removed by distillation under reduced pressure. The residue was dissolved in water (100 mL) and the pH of the solution was adjusted with concentrated hydrochloric acid to 5. The mixture was cooled to 0 °C and maintained for 30 min to promote product precipitation. The solid product was collected by filtration and washed with cold water (10 mL). Finally, the product was dried in a vacuum oven at 70 °C overnight to afford 2.75 g (91% yield) of the target compound 7-carboxybenzothiazole. The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 7.71 (t, J=7.5 Hz, 1H), 8.15 (d, J=7 Hz, 1H), 8.38 (d, J=8 Hz, 1H), 9.51 (s, 1H), 13.74 (bs, 1H); the mass spectrometry (APCI) showed m/z 178 (M+-1).
References
[1] Patent: WO2004/29050, 2004, A1. Location in patent: Page 69
[2] Patent: WO2005/92890, 2005, A2. Location in patent: Page/Page column 71
7-Benzothiazolecarboxylicacid(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Benzothiazolecarboxylicacid(9CI) manufacturers
- Product
- 7-Benzothiazolecarboxylicacid(9CI) 677304-83-5
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20