2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI)
Uses- Product Name
- 2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI)
- CAS No.
- 149586-32-3
- Chemical Name
- 2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI)
- Synonyms
- 2-Butenoicacid,4-(dimethylamino);Afatinib Impurity 85;4-DiMethylaMino-but-2-enoic acid;Trans-4-diMethylaMinocrotonic acid;(E)-4-(Dimethylamino)-2-butenoic acid;2-Butenoicacid,4-(dimethylamino)-,(E)-;(2E)-4-(Dimethylamino)-2-butenoic acid;2-Butenoic acid, 4-(dimethylamino)-, (2E)-;2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI);(E)-4-(Dimethylamino)but-2-enoic acid - [D90486]
- CBNumber
- CB31287926
- Molecular Formula
- C6H11NO2
- Formula Weight
- 129.16
- MOL File
- 149586-32-3.mol
2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI) Property
- Boiling point:
- 235.2±23.0 °C(Predicted)
- Density
- 1.049±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.70±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C6H11NO2/c1-7(2)5-3-4-6(8)9/h3-4H,5H2,1-2H3,(H,8,9)/b4-3+
- InChIKey
- ITGIYLMMAABTHC-ONEGZZNKSA-N
- SMILES
- C(O)(=O)/C=C/CN(C)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D461743
- Product name
- (2E)-4-(Dimethylamino)but-2-enoicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CD21013728
- Product name
- (E)-4-(Dimethylamino)but-2-enoicacid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $93
- Updated
- 2021/12/16
2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI) Chemical Properties,Usage,Production
Uses
(E)-4-(dimethylamino)but-2-enoic acid is a carboxylic acid derivative that can be used as an intermediate in organic synthesis.
Synthesis
1259519-60-2
149586-32-3
The general procedure for the synthesis of (E)-4-(dimethylamino)but-2-enoic acid from neratinib maleate SM3-IMP2 was as follows: 1.0 g of the compound obtained in step 1) was dissolved in 6.6 mL of methanol, followed by the addition of 2.2 mL of 40% aqueous sodium hydroxide solution. The reaction mixture was heated to 45 °C and the reaction was stirred at this temperature for 30 minutes. Upon completion of the reaction, the mixture was acidified to pH 2 with a 2-propanol solution of 10% hydrochloric acid, followed by filtration under reduced pressure. The filtrate was concentrated by reduced pressure distillation and then dissolved in 3 mL of 2-propanol, heated to 35°C and stirred for 10 minutes. Next, 3 mL of acetone was added to the solution and the mixture was stirred at 40°C for 30 minutes, followed by continued stirring at room temperature for 12 hours. At the end of the reaction, the resulting solid product was collected by filtration under reduced pressure, washed with a solvent mixture of 2-propanol and acetone (1:2, v/v), and finally dried under reduced pressure to afford the target product (E)-4-(dimethylamino)but-2-enoic acid (500 mg, 54% yield). The structure of the product was confirmed by 1H-NMR (300 MHz, DMSO-d6): δ 6.85 (m, 1H), 6.18 (m, 1H), 3.87 (d, 2H), 2.69 (s, 6H).
References
[1] Patent: WO2011/99764, 2011, A2. Location in patent: Page/Page column 22
2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI) Suppliers
- Tel
- 021-16621358918; 18516310516
- Fax
- 13045646768
- zhenlipharma888@163.com
- Country
- China
- ProdList
- 19035
- Advantage
- 58
- Tel
- 15250805028 15250805028;
- 649163353@qq.com
- Country
- China
- ProdList
- 8003
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- +86(0)21 60484900
- Fax
- +86(0)21 60484900
- Country
- China
- ProdList
- 764
- Advantage
- 50
- Tel
- 021-57816257 18930243658
- Fax
- 021-57816257
- fecpo@139.com
- Country
- China
- ProdList
- 295
- Advantage
- 55
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 025-58362220 0086-15250997978
- Fax
- 025-58362220
- sale@njxizebio.com
- Country
- China
- ProdList
- 4855
- Advantage
- 55
- Tel
- 0512-63009836 18994340901
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3981
- Advantage
- 60
View Lastest Price from 2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI) manufacturers
- Product
- 2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI) 149586-32-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2000
- Release date
- 2025-04-29
- Product
- Afatinib Impurity 85
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-06-04