3-Pyridinecarbonitrile,6-formyl-(9CI)
- Product Name
- 3-Pyridinecarbonitrile,6-formyl-(9CI)
- CAS No.
- 206201-64-1
- Chemical Name
- 3-Pyridinecarbonitrile,6-formyl-(9CI)
- Synonyms
- 6-Formylcyanopyridine;5-Cyano-pyridin-2-carbaldehyde;6-formylpyridine-3-carbonitrile;6-Formyl-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 6-formyl-;3-Pyridinecarbonitrile,6-formyl-(9CI)
- CBNumber
- CB31291765
- Molecular Formula
- C7H4N2O
- Formula Weight
- 132.12
- MOL File
- 206201-64-1.mol
3-Pyridinecarbonitrile,6-formyl-(9CI) Property
- Boiling point:
- 280.3±25.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.27±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F701425
- Product name
- 6-Formyl-3-pyridinecarbonitrile
- Packaging
- 25mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- F701425
- Product name
- 6-Formyl-3-pyridinecarbonitrile
- Packaging
- 100mg
- Price
- $235
- Updated
- 2021/12/16
- Product number
- CHM0391328
- Product name
- 6-FORMYLNICOTINONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.8
- Updated
- 2021/12/16
- Product number
- 119226
- Product name
- 6-Formylnicotinonitrile
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $504
- Updated
- 2021/12/16
- Product number
- 119226
- Product name
- 6-Formylnicotinonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1224
- Updated
- 2021/12/16
3-Pyridinecarbonitrile,6-formyl-(9CI) Chemical Properties,Usage,Production
Synthesis
3222-48-8
206201-64-1
The general procedure for the synthesis of 6-formylnicotinonitrile from 5-cyano-2-methylpyridine is as follows: a mixed solution of 6-methylnicotinonitrile (10.0 g, 84.6 mmol) and iodine (20.0 g, 78.8 mmol) in dimethylsulfoxide (150 mL) was heated and reacted for 20 min at 150 °C under nitrogen protection (the off-gas generated during the reaction was required to be passed through a bleach washing to remove the dimethyl sulfide). After completion of the reaction, the reaction mixture was cooled to room temperature and slowly neutralized by adding saturated aqueous sodium bicarbonate solution (200 mL). Subsequently, the mixture was extracted with toluene (3 x 100 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent, yielding the orange oily target product 6-formylnicotinonitrile (5.65 g, 50% yield), which could be used in subsequent reactions without further purification. The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 8.06 (1H, d), 8.17 (1H, dd), 9.05 (1H, d), 10.12 (1H, s).
References
[1] Chemical Science, 2015, vol. 7, # 1, p. 346 - 357
[2] Patent: WO2007/96763, 2007, A2. Location in patent: Page/Page column 60
[3] Patent: US2002/19527, 2002, A1
[4] Patent: WO2013/6408, 2013, A1. Location in patent: Page/Page column 43
[5] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 559 - 576
3-Pyridinecarbonitrile,6-formyl-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Pyridinecarbonitrile,6-formyl-(9CI) manufacturers
- Product
- 3-Pyridinecarbonitrile,6-formyl-(9CI) 206201-64-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-11-19