1H-Pyrazole-4-carbonitrile,5-amino-1-(1-methylethyl)-(9CI)
- Product Name
- 1H-Pyrazole-4-carbonitrile,5-amino-1-(1-methylethyl)-(9CI)
- CAS No.
- 21254-23-9
- Chemical Name
- 1H-Pyrazole-4-carbonitrile,5-amino-1-(1-methylethyl)-(9CI)
- Synonyms
- 5-AMINO-1-ISOPROPYL-1H-PYRAZOLE-4-CARBONITRILE;5-AMino-1-isopropyl-pyrazole-4-carbonitrile;5-amino-1-propan-2-yl-4-pyrazolecarbonitrile;5-amino-1-propan-2-ylpyrazole-4-carbonitrile;5-amino-1-(propan-2-yl)-1H-pyrazole-4-carbonitrile;1H-Pyrazole-4-carbonitrile, 5-amino-1-(1-methylethyl)-;1H-Pyrazole-4-carbonitrile,5-amino-1-(1-methylethyl)-(9CI)
- CBNumber
- CB31292489
- Molecular Formula
- C7H10N4
- Formula Weight
- 150.18
- MOL File
- 21254-23-9.mol
1H-Pyrazole-4-carbonitrile,5-amino-1-(1-methylethyl)-(9CI) Property
- storage temp.
- 2-8°C(protect from light)
- Appearance
- Yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- WAA25423
- Product name
- 5-amino-1-isopropyl-1h-pyrazole-4-carbonitrile
- Packaging
- 100mg
- Price
- $347
- Updated
- 2026/06/05
- Product number
- WAA25423
- Product name
- 5-amino-1-isopropyl-1h-pyrazole-4-carbonitrile
- Packaging
- 1g
- Price
- $885
- Updated
- 2026/06/05
- Product number
- 217884
- Product name
- 5-Amino-1-isopropyl-1H-pyrazole-4-carbonitrile
- Packaging
- 5.00g
- Price
- $1733
- Updated
- 2026/05/18
- Product number
- AA00BIM6
- Product name
- 5-Amino-1-isopropyl-1H-pyrazole-4-carbonitrile
- Purity
- 95%
- Packaging
- 100mg
- Price
- $155
- Updated
- 2026/05/28
- Product number
- AA00BIM6
- Product name
- 5-Amino-1-isopropyl-1H-pyrazole-4-carbonitrile
- Purity
- 95%
- Packaging
- 250mg
- Price
- $248
- Updated
- 2026/05/28
1H-Pyrazole-4-carbonitrile,5-amino-1-(1-methylethyl)-(9CI) Chemical Properties,Usage,Production
Synthesis
70629-60-6
123-06-8
21254-23-9
The general procedure for the synthesis of 5-amino-1-isopropyl-1H-pyrazole-4-carbonitrile from isopropylhydrazine dihydrochloride and ethoxymethylene malononitrile was as follows: ethoxymethylene malonitrile (12.83 g, 105 mmol) and isopropylhydrazine hydrochloride (11.06 g, 100 mmol) were dissolved in ethanol (250 mL). Subsequently, diisopropylethylamine (36.6 mL, 210 mmol) was added slowly and the temperature of the reaction mixture was increased. The reaction was continuously stirred at room temperature for about 18 hours. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure and the viscous yellow oil obtained was dissolved in dichloromethane and purified by a short silica gel column. The elution was first performed with dichloromethane (~300 mL) followed by a solvent mixture of ethyl acetate and hexane (1:1, ~750 mL). The eluate containing the target product was collected and concentrated under reduced pressure to give 5-amino-1-isopropyl-1H-pyrazole-4-carbonitrile (C20) as a light yellow solid. Yield: 12.1 g, 80.6 mmol, 81% yield.LC-MS m/z 151.1 (M + 1).1H NMR (400 MHz, DMSO-d6) δ 1.26 (d, J = 6.6 Hz, 6H), 4.41 (heptadecameric peaks, J = 6.5 Hz, 1H), 6.52 (broad single peak, 2H), 7.53 (single peak, 1H).
References
[1] Patent: US2010/190771, 2010, A1. Location in patent: Page/Page column 17
[2] Patent: WO2016/42775, 2016, A1. Location in patent: Paragraph 0177; 0179
[3] Patent: US2012/245144, 2012, A1. Location in patent: Page/Page column 98
1H-Pyrazole-4-carbonitrile,5-amino-1-(1-methylethyl)-(9CI) Preparation Products And Raw materials
Raw materials
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