6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONE

Product Name: 6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONE
CAS No.: 72908-87-3
Chemical Name: 6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONE
Synonyms: aldisin;aldisine;6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H);6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione;3,10-diazabicyclo[5.3.0]deca-8,11-diene-2,6-dione;6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONE;Pyrrolo[2,3-c]azepine-4,8(1H,5H)-dione, 6,7-dihydro-;Aldisin 6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione
CBNumber: CB3130605
Molecular Formula: C8H8N2O2
Formula Weight: 164.16
MOL File: 72908-87-3.mol

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6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONE Property

Melting point:: 286-288℃
Boiling point:: 555.9±39.0 °C(Predicted)
Density: 1.352±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 13.83±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0166420
Product name: 6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONE
Purity: 95.00%
Packaging: 5MG
Price: $504.15
Updated: 2021/12/16

AK Scientific

Product number: 6988CJ
Product name: 6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione
Packaging: 100mg
Price: $687
Updated: 2021/12/16

Abosyn

Product number: 61-10058
Product name: 6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione
Purity: 95-98%
Packaging: 1g
Price: $765
Updated: 2021/12/16

Alichem

Product number: 72908873
Product name: 6,7-Dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione
Packaging: 1g
Price: $542.58
Updated: 2021/12/16

Crysdot

Product number: CD11065873
Product name: 6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione
Purity: 97%
Packaging: 1g
Price: $632
Updated: 2021/12/16

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6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONE Chemical Properties,Usage,Production

Synthesis

129053-84-5

72908-87-3

GENERAL METHOD: Phosphorus pentoxide (2.02 g, 14.23 mmol) was dissolved in methanesulfonic acid (13 mL, 195.8 mmol), heated to 80 °C and stirred until homogeneous. Subsequently, 3-[(1H-pyrrole-2-carbonyl)-amino]propanoic acid (3.24 g, 17.78 mmol) was added, the reaction was continuously stirred and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was quenched with ice water and extracted several times with ethyl acetate. The organic phases were combined, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to afford 6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione as a white solid (1.58 g, 54% yield). The product was characterized by the following data: melting point 280-282 °C; IR (cm-1) 3222, 2931, 1659, 1634; 1H NMR (δ, ppm) 2.70 (2H, m), 3.35 (2H, m), 6.55 (1H, d, J = 2.7 Hz), 6.99 (1H, d, J = 2.7 Hz), 8.34 (1H, t, J = 4.7 Hz), 12.18 (1H, br s); 13C NMR (δ, ppm) 36.9, 43.8, 109.9, 122.7, 123.9, 128.3, 162.6, 194.7; LRMS (ES+) m/z 186.8 [M + Na]+; HRMS (ES+) 165.0657 ([M + H] +, calculated value 165.0664 for C8H9N2O2).

References

[1] Australian Journal of Chemistry, 1990, vol. 43, # 2, p. 355 - 365
[2] Organic Letters, 2005, vol. 7, # 25, p. 5641 - 5644
[3] Chemical and Pharmaceutical Bulletin, 1999, vol. 47, # 2, p. 246 - 256
[4] European Journal of Medicinal Chemistry, 2012, vol. 56, p. 246 - 253,8
[5] Journal of Heterocyclic Chemistry, 1997, vol. 34, # 1, p. 87 - 91

6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONE Suppliers

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72908-87-3, 6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONERelated Search:

6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONE 2-BROMO-6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONE

6,7-DIHYDRO-1H,5H-PYRROLO[2,3-C]AZEPINE-4,8-DIONE

aldisine

3,10-diazabicyclo[5.3.0]deca-8,11-diene-2,6-dione

6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione

aldisin

Aldisin 6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione

6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)

Pyrrolo[2,3-c]azepine-4,8(1H,5H)-dione, 6,7-dihydro-

72908-87-3

pharmacetical